Assessment of a Novel Enhanced Sampling Method for Molecular Simulations of Peptide-membrane Interactions
Gomesin is a spider-derived peptide with anti-microbial and anti-cancer properties which, like other such peptides, acts by permeabilising cell membranes. A new computer simulation approach was developed and tested to describe the interaction of Gomesin with model membranes. The findings will assist...
| Main Author: | |
|---|---|
| Format: | Thesis |
| Published: |
Curtin University
2020
|
| Online Access: | http://hdl.handle.net/20.500.11937/81846 |
| _version_ | 1848764436717764608 |
|---|---|
| author | Tanner, John Douglas |
| author_facet | Tanner, John Douglas |
| author_sort | Tanner, John Douglas |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Gomesin is a spider-derived peptide with anti-microbial and anti-cancer properties which, like other such peptides, acts by permeabilising cell membranes. A new computer simulation approach was developed and tested to describe the interaction of Gomesin with model membranes. The findings will assist the future development of simulation methods to better understand in detail the molecular mechanism of action of Gomesin and related peptides. |
| first_indexed | 2025-11-14T11:19:20Z |
| format | Thesis |
| id | curtin-20.500.11937-81846 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:19:20Z |
| publishDate | 2020 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-818462022-12-09T01:24:25Z Assessment of a Novel Enhanced Sampling Method for Molecular Simulations of Peptide-membrane Interactions Tanner, John Douglas Gomesin is a spider-derived peptide with anti-microbial and anti-cancer properties which, like other such peptides, acts by permeabilising cell membranes. A new computer simulation approach was developed and tested to describe the interaction of Gomesin with model membranes. The findings will assist the future development of simulation methods to better understand in detail the molecular mechanism of action of Gomesin and related peptides. 2020 Thesis http://hdl.handle.net/20.500.11937/81846 Curtin University fulltext |
| spellingShingle | Tanner, John Douglas Assessment of a Novel Enhanced Sampling Method for Molecular Simulations of Peptide-membrane Interactions |
| title | Assessment of a Novel Enhanced Sampling Method for Molecular Simulations of Peptide-membrane Interactions |
| title_full | Assessment of a Novel Enhanced Sampling Method for Molecular Simulations of Peptide-membrane Interactions |
| title_fullStr | Assessment of a Novel Enhanced Sampling Method for Molecular Simulations of Peptide-membrane Interactions |
| title_full_unstemmed | Assessment of a Novel Enhanced Sampling Method for Molecular Simulations of Peptide-membrane Interactions |
| title_short | Assessment of a Novel Enhanced Sampling Method for Molecular Simulations of Peptide-membrane Interactions |
| title_sort | assessment of a novel enhanced sampling method for molecular simulations of peptide-membrane interactions |
| url | http://hdl.handle.net/20.500.11937/81846 |