Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia.

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia.

Cancer cells display DNA hypermethylation at specific CpG islands in comparison to their normal healthy counterparts, but the mechanism that drives this so-called CpG island methylator phenotype (CIMP) remains poorly understood. Here, we show that CpG island methylation in human T-cell acute lymphob...

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Bibliographic Details
Main Authors: Roels, Juliette, Thénoz, Morgan, Szarzyńska, Bronisława, Landfors, Mattias, De Coninck, Stien, Demoen, Lisa, Provez, Lien, Kuchmiy, Anna, Strubbe, Steven, Reunes, Lindy, Pieters, Tim, Matthijssens, Filip, Van Loocke, Wouter, Erarslan-Uysal, Büşra, Richter-Pechańska, Paulina, Declerck, Ken, Lammens, Tim, De Moerloose, Barbara, Deforce, Dieter, Van Nieuwerburgh, Filip, Cheung, Laurence, Kotecha, Rishi S, Mansour, Marc R, Ghesquière, Bart, Van Camp, Guy, Berghe, Wim Vanden, Kowalczyk, Jerzy R, Szczepański, Tomasz, Davé, Utpal P, Kulozik, Andreas E, Goossens, Steven, Curtis, David J, Taghon, Tom, Dawidowska, Małgorzata, Degerman, Sofie, Van Vlierberghe, Pieter
Format: Journal Article
Language:English
Published: 2020
Subjects:
DNA methylation
Decitabine
T-ALL
aging
self-renewing thymocytes
Online Access:http://hdl.handle.net/20.500.11937/81750

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