A quantitative magnetic resonance histology atlas of rat brain development with regional estimates of growth and variability
There has been growing interest in the role of postnatal brain development in the etiology of several neurologic diseases. The rat has long been recognized as a powerful model system for studying neuropathology and the safety of pharmacologic treatments. However, the complex spatiotemporal changes t...
| Main Authors: | , , , |
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| Format: | Journal Article |
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Academic Press
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/8171 |
| _version_ | 1848745577484910592 |
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| author | Calabrese, E. Badea, A. Watson, Charles Johnson, G. |
| author_facet | Calabrese, E. Badea, A. Watson, Charles Johnson, G. |
| author_sort | Calabrese, E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | There has been growing interest in the role of postnatal brain development in the etiology of several neurologic diseases. The rat has long been recognized as a powerful model system for studying neuropathology and the safety of pharmacologic treatments. However, the complex spatiotemporal changes that occur during rat neurodevelopment remain to be elucidated. This work establishes the first magnetic resonance histology (MRH) atlas of the developing rat brain, with an emphasis on quantitation. The atlas comprises five specimens at each of nine time points, imaged with eight distinct MR contrasts and segmented into 26 developmentally defined brain regions. The atlas was used to establish a timeline of morphometric changes and variability throughout neurodevelopment and represents a quantitative database of rat neurodevelopment for characterizing rat models of human neurologic disease. |
| first_indexed | 2025-11-14T06:19:34Z |
| format | Journal Article |
| id | curtin-20.500.11937-8171 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:19:34Z |
| publishDate | 2013 |
| publisher | Academic Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-81712019-02-19T04:27:12Z A quantitative magnetic resonance histology atlas of rat brain development with regional estimates of growth and variability Calabrese, E. Badea, A. Watson, Charles Johnson, G. DTI Rat MRI Neurodevelopment Brain Atlas There has been growing interest in the role of postnatal brain development in the etiology of several neurologic diseases. The rat has long been recognized as a powerful model system for studying neuropathology and the safety of pharmacologic treatments. However, the complex spatiotemporal changes that occur during rat neurodevelopment remain to be elucidated. This work establishes the first magnetic resonance histology (MRH) atlas of the developing rat brain, with an emphasis on quantitation. The atlas comprises five specimens at each of nine time points, imaged with eight distinct MR contrasts and segmented into 26 developmentally defined brain regions. The atlas was used to establish a timeline of morphometric changes and variability throughout neurodevelopment and represents a quantitative database of rat neurodevelopment for characterizing rat models of human neurologic disease. 2013 Journal Article http://hdl.handle.net/20.500.11937/8171 10.1016/j.neuroimage.2013.01.017 Academic Press restricted |
| spellingShingle | DTI Rat MRI Neurodevelopment Brain Atlas Calabrese, E. Badea, A. Watson, Charles Johnson, G. A quantitative magnetic resonance histology atlas of rat brain development with regional estimates of growth and variability |
| title | A quantitative magnetic resonance histology atlas of rat brain development with regional estimates of growth and variability |
| title_full | A quantitative magnetic resonance histology atlas of rat brain development with regional estimates of growth and variability |
| title_fullStr | A quantitative magnetic resonance histology atlas of rat brain development with regional estimates of growth and variability |
| title_full_unstemmed | A quantitative magnetic resonance histology atlas of rat brain development with regional estimates of growth and variability |
| title_short | A quantitative magnetic resonance histology atlas of rat brain development with regional estimates of growth and variability |
| title_sort | quantitative magnetic resonance histology atlas of rat brain development with regional estimates of growth and variability |
| topic | DTI Rat MRI Neurodevelopment Brain Atlas |
| url | http://hdl.handle.net/20.500.11937/8171 |