Lysophosphatidylinositol-glucagon like peptide 1 crosstalk in metabolic diseases
This PhD thesis discusses the study of a novel class of drugs for the treatment of metabolic diseases. We have characterized the pharmacology and biology of the lipid Oleoyl-lysophosphatidylinositol (Oleoyl-LPI), and we show that some synthetic molecules mimicking its structure, are efficient glucag...
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| Format: | Thesis |
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Curtin University
2020
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| Online Access: | http://hdl.handle.net/20.500.11937/81689 |
| _version_ | 1848764404253851648 |
|---|---|
| author | Paternoster, Silvano |
| author_facet | Paternoster, Silvano |
| author_sort | Paternoster, Silvano |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This PhD thesis discusses the study of a novel class of drugs for the treatment of metabolic diseases. We have characterized the pharmacology and biology of the lipid Oleoyl-lysophosphatidylinositol (Oleoyl-LPI), and we show that some synthetic molecules mimicking its structure, are efficient glucagon-like peptide-1 (GLP-1) secreting drugs in vitro and in vivo in diabetic mice. We have also dissected the pharmacology of Cannabis-derived drugs and demonstrated that they can also modulate GLP-1 secretion. |
| first_indexed | 2025-11-14T11:18:49Z |
| format | Thesis |
| id | curtin-20.500.11937-81689 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:18:49Z |
| publishDate | 2020 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-816892022-11-14T02:39:20Z Lysophosphatidylinositol-glucagon like peptide 1 crosstalk in metabolic diseases Paternoster, Silvano This PhD thesis discusses the study of a novel class of drugs for the treatment of metabolic diseases. We have characterized the pharmacology and biology of the lipid Oleoyl-lysophosphatidylinositol (Oleoyl-LPI), and we show that some synthetic molecules mimicking its structure, are efficient glucagon-like peptide-1 (GLP-1) secreting drugs in vitro and in vivo in diabetic mice. We have also dissected the pharmacology of Cannabis-derived drugs and demonstrated that they can also modulate GLP-1 secretion. 2020 Thesis http://hdl.handle.net/20.500.11937/81689 Curtin University fulltext |
| spellingShingle | Paternoster, Silvano Lysophosphatidylinositol-glucagon like peptide 1 crosstalk in metabolic diseases |
| title | Lysophosphatidylinositol-glucagon like peptide 1 crosstalk in metabolic diseases |
| title_full | Lysophosphatidylinositol-glucagon like peptide 1 crosstalk in metabolic diseases |
| title_fullStr | Lysophosphatidylinositol-glucagon like peptide 1 crosstalk in metabolic diseases |
| title_full_unstemmed | Lysophosphatidylinositol-glucagon like peptide 1 crosstalk in metabolic diseases |
| title_short | Lysophosphatidylinositol-glucagon like peptide 1 crosstalk in metabolic diseases |
| title_sort | lysophosphatidylinositol-glucagon like peptide 1 crosstalk in metabolic diseases |
| url | http://hdl.handle.net/20.500.11937/81689 |