Novel Hydrophilic Copolymer-Based Nanoparticle Enhances the Therapeutic Efficiency of Doxorubicin in Cultured MCF-7 Cells
© 2019 American Chemical Society. Nanoparticle drug delivery applications have predominantly focused on the entrapment and delivery of hydrophobic molecules with poor water solubility. However, benefits can also be obtained from nanoparticle-based delivery of hydrophilic therapeutics. This study...
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| Format: | Journal Article |
| Language: | English |
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AMER CHEMICAL SOC
2019
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1087114 http://hdl.handle.net/20.500.11937/81497 |
| _version_ | 1848764378548011008 |
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| author | Naidu, P.S.R. Norret, M. Dunlop, S.A. Fitzgerald, Melinda Clemons, T.D. Iyer, K.S. |
| author_facet | Naidu, P.S.R. Norret, M. Dunlop, S.A. Fitzgerald, Melinda Clemons, T.D. Iyer, K.S. |
| author_sort | Naidu, P.S.R. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2019 American Chemical Society.
Nanoparticle drug delivery applications have predominantly focused on the entrapment and delivery of hydrophobic molecules with poor water solubility. However, benefits can also be obtained from nanoparticle-based delivery of hydrophilic therapeutics. This study reports on the development of a p(HEMA-ran-GMA)-based nanoparticle synthesized via a spontaneous water-in-oil inverse nanoemulsion to deliver doxorubicin, a water-soluble chemotherapeutic. High drug loading efficiency and sustained release of doxorubicin from Cy5-functionalized p(HEMA-ran-GMA) nanoparticles enabled effective inhibition of the MCF-7 human breast cancer derived cell line. Direct comparative analyses with a hydrophobic PGMA nanoparticle demonstrated enhanced capabilities of the p(HEMA-ran-GMA)-based nanoparticle in vitro. The results suggest that p(HEMA-ran-GMA)-based nanoparticles, which are better suited for hydrophilic drug loading and delivery, may have the potential for the improved therapeutic effect in vivo by enhanced permeation and retention of the nanoparticles by avoidance of off-site side effects of the chemotherapeutic. |
| first_indexed | 2025-11-14T11:18:24Z |
| format | Journal Article |
| id | curtin-20.500.11937-81497 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:18:24Z |
| publishDate | 2019 |
| publisher | AMER CHEMICAL SOC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-814972020-11-03T05:31:44Z Novel Hydrophilic Copolymer-Based Nanoparticle Enhances the Therapeutic Efficiency of Doxorubicin in Cultured MCF-7 Cells Naidu, P.S.R. Norret, M. Dunlop, S.A. Fitzgerald, Melinda Clemons, T.D. Iyer, K.S. Science & Technology Physical Sciences Chemistry, Multidisciplinary Chemistry POLYMERIC NANOPARTICLES PH BIODISTRIBUTION DRUGS © 2019 American Chemical Society. Nanoparticle drug delivery applications have predominantly focused on the entrapment and delivery of hydrophobic molecules with poor water solubility. However, benefits can also be obtained from nanoparticle-based delivery of hydrophilic therapeutics. This study reports on the development of a p(HEMA-ran-GMA)-based nanoparticle synthesized via a spontaneous water-in-oil inverse nanoemulsion to deliver doxorubicin, a water-soluble chemotherapeutic. High drug loading efficiency and sustained release of doxorubicin from Cy5-functionalized p(HEMA-ran-GMA) nanoparticles enabled effective inhibition of the MCF-7 human breast cancer derived cell line. Direct comparative analyses with a hydrophobic PGMA nanoparticle demonstrated enhanced capabilities of the p(HEMA-ran-GMA)-based nanoparticle in vitro. The results suggest that p(HEMA-ran-GMA)-based nanoparticles, which are better suited for hydrophilic drug loading and delivery, may have the potential for the improved therapeutic effect in vivo by enhanced permeation and retention of the nanoparticles by avoidance of off-site side effects of the chemotherapeutic. 2019 Journal Article http://hdl.handle.net/20.500.11937/81497 10.1021/acsomega.8b02894 English http://purl.org/au-research/grants/nhmrc/1087114 http://creativecommons.org/licenses/by-nc/4.0/ AMER CHEMICAL SOC fulltext |
| spellingShingle | Science & Technology Physical Sciences Chemistry, Multidisciplinary Chemistry POLYMERIC NANOPARTICLES PH BIODISTRIBUTION DRUGS Naidu, P.S.R. Norret, M. Dunlop, S.A. Fitzgerald, Melinda Clemons, T.D. Iyer, K.S. Novel Hydrophilic Copolymer-Based Nanoparticle Enhances the Therapeutic Efficiency of Doxorubicin in Cultured MCF-7 Cells |
| title | Novel Hydrophilic Copolymer-Based Nanoparticle Enhances the Therapeutic Efficiency of Doxorubicin in Cultured MCF-7 Cells |
| title_full | Novel Hydrophilic Copolymer-Based Nanoparticle Enhances the Therapeutic Efficiency of Doxorubicin in Cultured MCF-7 Cells |
| title_fullStr | Novel Hydrophilic Copolymer-Based Nanoparticle Enhances the Therapeutic Efficiency of Doxorubicin in Cultured MCF-7 Cells |
| title_full_unstemmed | Novel Hydrophilic Copolymer-Based Nanoparticle Enhances the Therapeutic Efficiency of Doxorubicin in Cultured MCF-7 Cells |
| title_short | Novel Hydrophilic Copolymer-Based Nanoparticle Enhances the Therapeutic Efficiency of Doxorubicin in Cultured MCF-7 Cells |
| title_sort | novel hydrophilic copolymer-based nanoparticle enhances the therapeutic efficiency of doxorubicin in cultured mcf-7 cells |
| topic | Science & Technology Physical Sciences Chemistry, Multidisciplinary Chemistry POLYMERIC NANOPARTICLES PH BIODISTRIBUTION DRUGS |
| url | http://purl.org/au-research/grants/nhmrc/1087114 http://hdl.handle.net/20.500.11937/81497 |