Applying neutral drift to the directed molecular evolution of a β-glucuronidase into a β-galactosidase: Two different evolutionary pathways lead to the same variant

Applying neutral drift to the directed molecular evolution of a β-glucuronidase into a β-galactosidase: Two different evolutionary pathways lead to the same variant

Background: Directed protein evolution has been used to modify protein activity and research has been carried out to enhance the production of high quality mutant libraries. Many theoretical approaches suggest that allowing a population to undergo neutral selection may be valuable in directed evolut...

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Bibliographic Details
Main Authors: Smith, W.S., Hale, J.R., Neylon, Cameron
Format: Journal Article
Language:English
Published: 2011
Online Access:http://hdl.handle.net/20.500.11937/81474

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