The design, synthesis and biological evaluation of novel URB602 analogues as potential monoacylglycerol lipase inhibitors

The design, synthesis and biological evaluation of novel URB602 analogues as potential monoacylglycerol lipase inhibitors

We have synthesised an extensive series of URB602 analogues as inhibitors of monoacylglycerol lipase (MAGL), which is the major enzyme responsible for metabolising the endocannabinoid 2-arachidonylglycerol. The recently identified crystal structure of MAGL was used in the design strategy and reveale...

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Bibliographic Details
Main Authors: Szabo, M., Agostino, Mark, Malone, D., Yuriev, E., Capuano, B.
Format: Journal Article
Published: Pergamon 2011
Subjects:
Monoacylglycerol lipase
Endocannabinoid system
Structure–activity relationship
2-Arachidonylglycerol
URB602
Online Access:http://hdl.handle.net/20.500.11937/8137

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