Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia
© 2020 Elsevier Ltd Of 1033 Escherichia coli urinary tract infection isolates collected from females >12 years of age in Australia in 2019, only 2 isolates were resistant to fosfomycin with a minimum inhibitory concentration (MIC) of >256 mg/L. Despite having different multilocus sequence...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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Elsevier
2020
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/81354 |
| _version_ | 1848764353986166784 |
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| author | Mowlaboccus, S. Daley, D. Pang, S. Gottlieb, T. Merlino, J. Nimmo, G.R. George, N. Korman, T.M. Streitberg, R. Robson, J. Peachey, G. Collignon, P. Bradbury, S. Colombi, Elena Ramsay, Josh Rogers, B.A. Coombs, G.W. |
| author_facet | Mowlaboccus, S. Daley, D. Pang, S. Gottlieb, T. Merlino, J. Nimmo, G.R. George, N. Korman, T.M. Streitberg, R. Robson, J. Peachey, G. Collignon, P. Bradbury, S. Colombi, Elena Ramsay, Josh Rogers, B.A. Coombs, G.W. |
| author_sort | Mowlaboccus, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2020 Elsevier Ltd
Of 1033 Escherichia coli urinary tract infection isolates collected from females >12 years of age in Australia in 2019, only 2 isolates were resistant to fosfomycin with a minimum inhibitory concentration (MIC) of >256 mg/L. Despite having different multilocus sequence types, the two isolates harboured an identical plasmid-encoded fosA4 gene. The fosA4 gene has previously been identified in a single clinical E. coli isolate cultured in Japan in 2014. Each fosfomycin-resistant isolate harboured two conjugative plasmids that possessed an array of genes conferring resistance to aminoglycosides, β-lactams, macrolides, quinolones, sulfonamides and/or trimethoprim. |
| first_indexed | 2025-11-14T11:18:01Z |
| format | Journal Article |
| id | curtin-20.500.11937-81354 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:18:01Z |
| publishDate | 2020 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-813542021-08-06T06:01:57Z Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia Mowlaboccus, S. Daley, D. Pang, S. Gottlieb, T. Merlino, J. Nimmo, G.R. George, N. Korman, T.M. Streitberg, R. Robson, J. Peachey, G. Collignon, P. Bradbury, S. Colombi, Elena Ramsay, Josh Rogers, B.A. Coombs, G.W. Escherichia coli Fosfomycin resistance Urinary tract infection fosA4 © 2020 Elsevier Ltd Of 1033 Escherichia coli urinary tract infection isolates collected from females >12 years of age in Australia in 2019, only 2 isolates were resistant to fosfomycin with a minimum inhibitory concentration (MIC) of >256 mg/L. Despite having different multilocus sequence types, the two isolates harboured an identical plasmid-encoded fosA4 gene. The fosA4 gene has previously been identified in a single clinical E. coli isolate cultured in Japan in 2014. Each fosfomycin-resistant isolate harboured two conjugative plasmids that possessed an array of genes conferring resistance to aminoglycosides, β-lactams, macrolides, quinolones, sulfonamides and/or trimethoprim. 2020 Journal Article http://hdl.handle.net/20.500.11937/81354 10.1016/j.ijantimicag.2020.106121 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ Elsevier fulltext |
| spellingShingle | Escherichia coli Fosfomycin resistance Urinary tract infection fosA4 Mowlaboccus, S. Daley, D. Pang, S. Gottlieb, T. Merlino, J. Nimmo, G.R. George, N. Korman, T.M. Streitberg, R. Robson, J. Peachey, G. Collignon, P. Bradbury, S. Colombi, Elena Ramsay, Josh Rogers, B.A. Coombs, G.W. Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia |
| title | Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia |
| title_full | Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia |
| title_fullStr | Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia |
| title_full_unstemmed | Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia |
| title_short | Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia |
| title_sort | identification and characterisation of fosfomycin resistance in escherichia coli urinary tract infection isolates from australia |
| topic | Escherichia coli Fosfomycin resistance Urinary tract infection fosA4 |
| url | http://hdl.handle.net/20.500.11937/81354 |