Altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group II metabotropic glutamate receptor agonist LY379268
Temporal order memory refers to the ability to distinguish past experiences in the order that they occurred. Temporal order memory for objects is often tested in rodents using spontaneous object recognition paradigms. The circuitry mediating memory in these tests is distributed and involves ionotrop...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | English |
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2014
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| Online Access: | http://hdl.handle.net/20.500.11937/81126 |
| _version_ | 1848764321210826752 |
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| author | Lins, Brittney Ballendine, S.A. Howland, J.G. |
| author_facet | Lins, Brittney Ballendine, S.A. Howland, J.G. |
| author_sort | Lins, Brittney |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Temporal order memory refers to the ability to distinguish past experiences in the order that they occurred. Temporal order memory for objects is often tested in rodents using spontaneous object recognition paradigms. The circuitry mediating memory in these tests is distributed and involves ionotropic glutamate receptors in the perirhinal cortex and medial prefrontal cortex. It is unknown what role, if any, metabotropic glutamate receptors have in temporal order memory for objects. The present experiment examined the role of metabotropic glutamate receptors in temporal memory retrieval using the group II metabotropic glutamate receptor selective agonist LY379268. Rats were trained on a temporal memory test with three phases: two sample phases (60. min between them) in which rats explored two novel objects and a test phase (60. min after the second sample phase) which included a copy of each object previously encountered. Under these conditions, we confirmed that rats showed a significant exploratory preference for the object presented during the first sample phase. In a second experiment, we found that LY379268 (0.3, 1.0, or 3.0. mg/kg; i.p.; 30. min before the test phase) had no effect on temporal memory retrieval but dose-dependently reduced time spent exploring the objects. Our results show that enhancing mGluR2 activity under conditions when TM is intact does not influence memory retrieval. © 2013 Elsevier Ireland Ltd. |
| first_indexed | 2025-11-14T11:17:30Z |
| format | Journal Article |
| id | curtin-20.500.11937-81126 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:17:30Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-811262021-01-15T06:58:29Z Altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group II metabotropic glutamate receptor agonist LY379268 Lins, Brittney Ballendine, S.A. Howland, J.G. Cognition Delayed recency discrimination Medial prefrontal cortex Metabotropic glutamate receptor Spontaneous object recognition Amino Acids Animals Bridged Bicyclo Compounds, Heterocyclic Discrimination, Psychological Exploratory Behavior Male Memory Rats, Long-Evans Receptors, Metabotropic Glutamate Recognition, Psychology Time Factors Temporal order memory refers to the ability to distinguish past experiences in the order that they occurred. Temporal order memory for objects is often tested in rodents using spontaneous object recognition paradigms. The circuitry mediating memory in these tests is distributed and involves ionotropic glutamate receptors in the perirhinal cortex and medial prefrontal cortex. It is unknown what role, if any, metabotropic glutamate receptors have in temporal order memory for objects. The present experiment examined the role of metabotropic glutamate receptors in temporal memory retrieval using the group II metabotropic glutamate receptor selective agonist LY379268. Rats were trained on a temporal memory test with three phases: two sample phases (60. min between them) in which rats explored two novel objects and a test phase (60. min after the second sample phase) which included a copy of each object previously encountered. Under these conditions, we confirmed that rats showed a significant exploratory preference for the object presented during the first sample phase. In a second experiment, we found that LY379268 (0.3, 1.0, or 3.0. mg/kg; i.p.; 30. min before the test phase) had no effect on temporal memory retrieval but dose-dependently reduced time spent exploring the objects. Our results show that enhancing mGluR2 activity under conditions when TM is intact does not influence memory retrieval. © 2013 Elsevier Ireland Ltd. 2014 Journal Article http://hdl.handle.net/20.500.11937/81126 10.1016/j.neulet.2013.12.016 eng restricted |
| spellingShingle | Cognition Delayed recency discrimination Medial prefrontal cortex Metabotropic glutamate receptor Spontaneous object recognition Amino Acids Animals Bridged Bicyclo Compounds, Heterocyclic Discrimination, Psychological Exploratory Behavior Male Memory Rats, Long-Evans Receptors, Metabotropic Glutamate Recognition, Psychology Time Factors Lins, Brittney Ballendine, S.A. Howland, J.G. Altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group II metabotropic glutamate receptor agonist LY379268 |
| title | Altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group II metabotropic glutamate receptor agonist LY379268 |
| title_full | Altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group II metabotropic glutamate receptor agonist LY379268 |
| title_fullStr | Altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group II metabotropic glutamate receptor agonist LY379268 |
| title_full_unstemmed | Altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group II metabotropic glutamate receptor agonist LY379268 |
| title_short | Altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group II metabotropic glutamate receptor agonist LY379268 |
| title_sort | altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group ii metabotropic glutamate receptor agonist ly379268 |
| topic | Cognition Delayed recency discrimination Medial prefrontal cortex Metabotropic glutamate receptor Spontaneous object recognition Amino Acids Animals Bridged Bicyclo Compounds, Heterocyclic Discrimination, Psychological Exploratory Behavior Male Memory Rats, Long-Evans Receptors, Metabotropic Glutamate Recognition, Psychology Time Factors |
| url | http://hdl.handle.net/20.500.11937/81126 |