Effects of the metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on rats tested with the paired associates learning task in touchscreen-equipped operant conditioning chambers
© 2015 Elsevier B.V. Effective treatments for the cognitive symptoms of schizophrenia are critically needed. Positive allosteric modulation (PAM) of metabotropic glutamate receptor subtype 5 (mGluR5) is one strategy currently under investigation to improve these symptoms. Examining cognition using t...
| Main Authors: | , |
|---|---|
| Format: | Journal Article |
| Language: | English |
| Published: |
2016
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/81124 |
| _version_ | 1848764320690733056 |
|---|---|
| author | Lins, Brittney Howland, J.G. |
| author_facet | Lins, Brittney Howland, J.G. |
| author_sort | Lins, Brittney |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2015 Elsevier B.V. Effective treatments for the cognitive symptoms of schizophrenia are critically needed. Positive allosteric modulation (PAM) of metabotropic glutamate receptor subtype 5 (mGluR5) is one strategy currently under investigation to improve these symptoms. Examining cognition using touchscreen-equipped operant chambers may increase translation between preclinical and clinical research through analogous behavioral testing paradigms in rodents and humans. We used acute CDPPB (1-30mg/kg) treatment to examine the effects of mGluR5 PAM in the touchscreen paired associates learning (PAL) task using well-trained rats with and without co-administration of acute MK-801 (0.15mg/kg). CDPPB had no consistent effects on task performance when administered alone and failed to reverse the MK-801 induced impairments at any of the examined doses. Overall, the disruptive effects of MK-801 on PAL were consistent with previous research but increasing mGluR5 signaling is not beneficial in the PAL task. Future research should test whether administration of CDPPB during PAL acquisition increases performance. |
| first_indexed | 2025-11-14T11:17:29Z |
| format | Journal Article |
| id | curtin-20.500.11937-81124 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:17:29Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-811242021-01-15T06:58:29Z Effects of the metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on rats tested with the paired associates learning task in touchscreen-equipped operant conditioning chambers Lins, Brittney Howland, J.G. Cognition Glutamate MK-801 NMDA receptor Operant conditioning Schizophrenia Animals Association Learning Benzamides Compulsive Behavior Conditioning, Operant Dizocilpine Maleate Dose-Response Relationship, Drug Excitatory Amino Acid Agents Male Neuropsychological Tests Pyrazoles Rats, Long-Evans Receptor, Metabotropic Glutamate 5 © 2015 Elsevier B.V. Effective treatments for the cognitive symptoms of schizophrenia are critically needed. Positive allosteric modulation (PAM) of metabotropic glutamate receptor subtype 5 (mGluR5) is one strategy currently under investigation to improve these symptoms. Examining cognition using touchscreen-equipped operant chambers may increase translation between preclinical and clinical research through analogous behavioral testing paradigms in rodents and humans. We used acute CDPPB (1-30mg/kg) treatment to examine the effects of mGluR5 PAM in the touchscreen paired associates learning (PAL) task using well-trained rats with and without co-administration of acute MK-801 (0.15mg/kg). CDPPB had no consistent effects on task performance when administered alone and failed to reverse the MK-801 induced impairments at any of the examined doses. Overall, the disruptive effects of MK-801 on PAL were consistent with previous research but increasing mGluR5 signaling is not beneficial in the PAL task. Future research should test whether administration of CDPPB during PAL acquisition increases performance. 2016 Journal Article http://hdl.handle.net/20.500.11937/81124 10.1016/j.bbr.2015.12.029 eng restricted |
| spellingShingle | Cognition Glutamate MK-801 NMDA receptor Operant conditioning Schizophrenia Animals Association Learning Benzamides Compulsive Behavior Conditioning, Operant Dizocilpine Maleate Dose-Response Relationship, Drug Excitatory Amino Acid Agents Male Neuropsychological Tests Pyrazoles Rats, Long-Evans Receptor, Metabotropic Glutamate 5 Lins, Brittney Howland, J.G. Effects of the metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on rats tested with the paired associates learning task in touchscreen-equipped operant conditioning chambers |
| title | Effects of the metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on rats tested with the paired associates learning task in touchscreen-equipped operant conditioning chambers |
| title_full | Effects of the metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on rats tested with the paired associates learning task in touchscreen-equipped operant conditioning chambers |
| title_fullStr | Effects of the metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on rats tested with the paired associates learning task in touchscreen-equipped operant conditioning chambers |
| title_full_unstemmed | Effects of the metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on rats tested with the paired associates learning task in touchscreen-equipped operant conditioning chambers |
| title_short | Effects of the metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on rats tested with the paired associates learning task in touchscreen-equipped operant conditioning chambers |
| title_sort | effects of the metabotropic glutamate receptor 5 positive allosteric modulator cdppb on rats tested with the paired associates learning task in touchscreen-equipped operant conditioning chambers |
| topic | Cognition Glutamate MK-801 NMDA receptor Operant conditioning Schizophrenia Animals Association Learning Benzamides Compulsive Behavior Conditioning, Operant Dizocilpine Maleate Dose-Response Relationship, Drug Excitatory Amino Acid Agents Male Neuropsychological Tests Pyrazoles Rats, Long-Evans Receptor, Metabotropic Glutamate 5 |
| url | http://hdl.handle.net/20.500.11937/81124 |