A sequence symmetry analysis of the interrelationships between statins, diabetes and skin infections
© 2019 The British Pharmacological Society Aims: To determine statins' impact on skin infection risk in view of conflicting literature: that statins may reduce infection risk, but are also associated with diabetes mellitus, a risk factor for skin and soft tissue infections (SSTIs). Meth...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal Article |
| Language: | English |
| Published: |
WILEY
2019
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/80905 |
| _version_ | 1848764286699044864 |
|---|---|
| author | Ko, Humphrey H.T. Lareu, Ricky Dix, Brett Hughes, Jeffery Parsons, Richard |
| author_facet | Ko, Humphrey H.T. Lareu, Ricky Dix, Brett Hughes, Jeffery Parsons, Richard |
| author_sort | Ko, Humphrey H.T. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2019 The British Pharmacological Society
Aims: To determine statins' impact on skin infection risk in view of conflicting literature: that statins may reduce infection risk, but are also associated with diabetes mellitus, a risk factor for skin and soft tissue infections (SSTIs).
Methods: Sequence symmetry analysis was performed on prescription claims (2001–2011) from the Australian Department of Veterans' Affairs to determine the interrelationships between: (i) statins and SSTIs; (ii) statins and diabetes; and (iii) diabetes and SSTIs; as well as whether statins increased the risk of SSTIs, independent of diabetes status. Chi-square tests were performed to detect differences in Index of Relative Socio-economic Advantage and Disadvantage scores of patients within each interrelationship. Prescriptions for statins, antidiabetic medication, and antistaphylococcal antibiotics were evaluated using nonidentifiable client numbers, prescription dates filled, residential electorates, and pharmaceutical codes. Adjusted sequence ratio and confidence interval were calculated at intervals of 91, 182 and 365 days for sequence symmetry analysis studies.
Results: Statins were associated with: (i) significant SSTI risk (adjusted sequence ratio > 1; confidence interval >1), (ii) significant diabetes risk, and (iii) diabetic patients had increased risk of SSTIs. Diabetic and nondiabetic statin users had significantly increased risks of SSTIs, while the influence from socioeconomic status was not significant for each of the 3 relationships.
Conclusions: Statins are associated with increased risk of SSTIs via direct and indirect mechanisms, probably independent of diabetes or socioeconomic statuses. We believe that clinicians should be aware of the association between statins and SSTIs, and, where appropriate, monitor blood glucose levels of statin users. |
| first_indexed | 2025-11-14T11:16:57Z |
| format | Journal Article |
| id | curtin-20.500.11937-80905 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:16:57Z |
| publishDate | 2019 |
| publisher | WILEY |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-809052021-02-10T05:14:02Z A sequence symmetry analysis of the interrelationships between statins, diabetes and skin infections Ko, Humphrey H.T. Lareu, Ricky Dix, Brett Hughes, Jeffery Parsons, Richard Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy antibiotics diabetes pharmacoepidemiology statins COA REDUCTASE INHIBITORS SOFT-TISSUE INFECTIONS VITAMIN-D BACTERIAL SKIN GUT DYSBIOSIS PRESCRIPTION THERAPY RISK EPIDEMIOLOGY © 2019 The British Pharmacological Society Aims: To determine statins' impact on skin infection risk in view of conflicting literature: that statins may reduce infection risk, but are also associated with diabetes mellitus, a risk factor for skin and soft tissue infections (SSTIs). Methods: Sequence symmetry analysis was performed on prescription claims (2001–2011) from the Australian Department of Veterans' Affairs to determine the interrelationships between: (i) statins and SSTIs; (ii) statins and diabetes; and (iii) diabetes and SSTIs; as well as whether statins increased the risk of SSTIs, independent of diabetes status. Chi-square tests were performed to detect differences in Index of Relative Socio-economic Advantage and Disadvantage scores of patients within each interrelationship. Prescriptions for statins, antidiabetic medication, and antistaphylococcal antibiotics were evaluated using nonidentifiable client numbers, prescription dates filled, residential electorates, and pharmaceutical codes. Adjusted sequence ratio and confidence interval were calculated at intervals of 91, 182 and 365 days for sequence symmetry analysis studies. Results: Statins were associated with: (i) significant SSTI risk (adjusted sequence ratio > 1; confidence interval >1), (ii) significant diabetes risk, and (iii) diabetic patients had increased risk of SSTIs. Diabetic and nondiabetic statin users had significantly increased risks of SSTIs, while the influence from socioeconomic status was not significant for each of the 3 relationships. Conclusions: Statins are associated with increased risk of SSTIs via direct and indirect mechanisms, probably independent of diabetes or socioeconomic statuses. We believe that clinicians should be aware of the association between statins and SSTIs, and, where appropriate, monitor blood glucose levels of statin users. 2019 Journal Article http://hdl.handle.net/20.500.11937/80905 10.1111/bcp.14077 English WILEY fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy antibiotics diabetes pharmacoepidemiology statins COA REDUCTASE INHIBITORS SOFT-TISSUE INFECTIONS VITAMIN-D BACTERIAL SKIN GUT DYSBIOSIS PRESCRIPTION THERAPY RISK EPIDEMIOLOGY Ko, Humphrey H.T. Lareu, Ricky Dix, Brett Hughes, Jeffery Parsons, Richard A sequence symmetry analysis of the interrelationships between statins, diabetes and skin infections |
| title | A sequence symmetry analysis of the interrelationships between statins, diabetes and skin infections |
| title_full | A sequence symmetry analysis of the interrelationships between statins, diabetes and skin infections |
| title_fullStr | A sequence symmetry analysis of the interrelationships between statins, diabetes and skin infections |
| title_full_unstemmed | A sequence symmetry analysis of the interrelationships between statins, diabetes and skin infections |
| title_short | A sequence symmetry analysis of the interrelationships between statins, diabetes and skin infections |
| title_sort | sequence symmetry analysis of the interrelationships between statins, diabetes and skin infections |
| topic | Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy antibiotics diabetes pharmacoepidemiology statins COA REDUCTASE INHIBITORS SOFT-TISSUE INFECTIONS VITAMIN-D BACTERIAL SKIN GUT DYSBIOSIS PRESCRIPTION THERAPY RISK EPIDEMIOLOGY |
| url | http://hdl.handle.net/20.500.11937/80905 |