Bile acid-based micro/nano capsules for the targeted oral delivery of probucol
Probucol has shown its protective effect on pancreatic beta cells from inflammation and oxidation, but, it is a highly lipophilic oral drug with poor gut absorption and significant side effects that resulted in restrictions on its clinical prescribing. This study aimed to design new delivery systems...
| Main Author: | |
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| Format: | Thesis |
| Published: |
Curtin University
2020
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| Online Access: | http://hdl.handle.net/20.500.11937/80870 |
| _version_ | 1848764286138056704 |
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| author | Wagle, Susbin Raj |
| author_facet | Wagle, Susbin Raj |
| author_sort | Wagle, Susbin Raj |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Probucol has shown its protective effect on pancreatic beta cells from inflammation and oxidation, but, it is a highly lipophilic oral drug with poor gut absorption and significant side effects that resulted in restrictions on its clinical prescribing. This study aimed to design new delivery systems for probucol using Lithocholic acid-based microcapsules to overcome these limitations and showed promising results. |
| first_indexed | 2025-11-14T11:16:56Z |
| format | Thesis |
| id | curtin-20.500.11937-80870 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:16:56Z |
| publishDate | 2020 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-808702022-09-05T04:48:33Z Bile acid-based micro/nano capsules for the targeted oral delivery of probucol Wagle, Susbin Raj Probucol has shown its protective effect on pancreatic beta cells from inflammation and oxidation, but, it is a highly lipophilic oral drug with poor gut absorption and significant side effects that resulted in restrictions on its clinical prescribing. This study aimed to design new delivery systems for probucol using Lithocholic acid-based microcapsules to overcome these limitations and showed promising results. 2020 Thesis http://hdl.handle.net/20.500.11937/80870 Curtin University fulltext |
| spellingShingle | Wagle, Susbin Raj Bile acid-based micro/nano capsules for the targeted oral delivery of probucol |
| title | Bile acid-based micro/nano capsules for the targeted oral delivery of probucol |
| title_full | Bile acid-based micro/nano capsules for the targeted oral delivery of probucol |
| title_fullStr | Bile acid-based micro/nano capsules for the targeted oral delivery of probucol |
| title_full_unstemmed | Bile acid-based micro/nano capsules for the targeted oral delivery of probucol |
| title_short | Bile acid-based micro/nano capsules for the targeted oral delivery of probucol |
| title_sort | bile acid-based micro/nano capsules for the targeted oral delivery of probucol |
| url | http://hdl.handle.net/20.500.11937/80870 |