A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment. Unfortunately, few pharmacological treatments exist to alleviate these socio-behavioural impairments. Prenatal administration of...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/80741 |
| _version_ | 1848764263033733120 |
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| author | Chaliha, Devahuti Albrecht, Matthew Vaccarezza, Mauro Takechi, Ryu Lam, Virginie Al-Salami, Hani Mamo, John |
| author_facet | Chaliha, Devahuti Albrecht, Matthew Vaccarezza, Mauro Takechi, Ryu Lam, Virginie Al-Salami, Hani Mamo, John |
| author_sort | Chaliha, Devahuti |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment. Unfortunately, few pharmacological treatments exist to alleviate these socio-behavioural impairments. Prenatal administration of valproic acid (VPA) has become an accepted animal model of ASD and has been extensively used to explore new pharmacotherapies in rodents. We conducted a systematic review of the behavioural impairments induced by the VPA model in rodents, with specific reference to 3 core socio-behavioural alterations associated with ASD: repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment. We systematically reviewed studies attempting to alleviate these core behavioural alterations using pharmacological means. We include 132 studies exploring the prenatal effects of VPA in rodents. Gestational exposure to VPA in rodents has significant effects on rodent-equivalent measures of the 3 core behavioural traits characteristic of ASD in humans, inducing social impairments, repetitive behaviour, and cognitive rigidity/inflexibility after birth. This model's validity has seen it used to test potential drug treatments for ASD and is likely to continue doing so. We conclude the rodent VPA model may be suitable to examine future therapeutic interventions for ASD, providing an overview of the progress made so far. |
| first_indexed | 2025-11-14T11:16:34Z |
| format | Journal Article |
| id | curtin-20.500.11937-80741 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:16:34Z |
| publishDate | 2020 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-807412020-08-31T03:00:47Z A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism. Chaliha, Devahuti Albrecht, Matthew Vaccarezza, Mauro Takechi, Ryu Lam, Virginie Al-Salami, Hani Mamo, John Autism Behaviour Rodent Valproic acid Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment. Unfortunately, few pharmacological treatments exist to alleviate these socio-behavioural impairments. Prenatal administration of valproic acid (VPA) has become an accepted animal model of ASD and has been extensively used to explore new pharmacotherapies in rodents. We conducted a systematic review of the behavioural impairments induced by the VPA model in rodents, with specific reference to 3 core socio-behavioural alterations associated with ASD: repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment. We systematically reviewed studies attempting to alleviate these core behavioural alterations using pharmacological means. We include 132 studies exploring the prenatal effects of VPA in rodents. Gestational exposure to VPA in rodents has significant effects on rodent-equivalent measures of the 3 core behavioural traits characteristic of ASD in humans, inducing social impairments, repetitive behaviour, and cognitive rigidity/inflexibility after birth. This model's validity has seen it used to test potential drug treatments for ASD and is likely to continue doing so. We conclude the rodent VPA model may be suitable to examine future therapeutic interventions for ASD, providing an overview of the progress made so far. 2020 Journal Article http://hdl.handle.net/20.500.11937/80741 10.1159/000509109 eng unknown |
| spellingShingle | Autism Behaviour Rodent Valproic acid Chaliha, Devahuti Albrecht, Matthew Vaccarezza, Mauro Takechi, Ryu Lam, Virginie Al-Salami, Hani Mamo, John A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism. |
| title | A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism. |
| title_full | A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism. |
| title_fullStr | A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism. |
| title_full_unstemmed | A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism. |
| title_short | A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism. |
| title_sort | systematic review of the valproic-acid-induced rodent model of autism. |
| topic | Autism Behaviour Rodent Valproic acid |
| url | http://hdl.handle.net/20.500.11937/80741 |