NK cells: A double edge sword against SARS-CoV-2
© 2020 Elsevier Ltd Natural killer (NK) cells are pivotal effectors of the innate immunity protecting an individual from microbes. They are the first line of defense against invading viruses, given their substantial ability to directly target infected cells without the need for specific antigen...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
2020
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| Online Access: | http://hdl.handle.net/20.500.11937/80200 |
| _version_ | 1848764180049428480 |
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| author | Masselli, E. Vaccarezza, Mauro Carubbi, C. Pozzi, G. Presta, V. Mirandola, P. Vitale, M. |
| author_facet | Masselli, E. Vaccarezza, Mauro Carubbi, C. Pozzi, G. Presta, V. Mirandola, P. Vitale, M. |
| author_sort | Masselli, E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2020 Elsevier Ltd
Natural killer (NK) cells are pivotal effectors of the innate immunity protecting an individual from microbes. They are the first line of defense against invading viruses, given their substantial ability to directly target infected cells without the need for specific antigen presentation. By establishing cellular networks with a variety of cell types such as dendritic cells, NK cells can also amplify and modulate antiviral adaptive immune responses. In this review, we will examine the role of NK cells in SARS-COV2 infections causing the ongoing COVID19 pandemic, keeping in mind the controversial role of NK cells specifically in viral respiratory infections and in inflammatory-driven lung damage. We discuss lessons learnt from previous coronavirus outbreaks in humans (caused by SARS-CoV-1 and MERS-COV). |
| first_indexed | 2025-11-14T11:15:15Z |
| format | Journal Article |
| id | curtin-20.500.11937-80200 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:15:15Z |
| publishDate | 2020 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-802002020-08-14T01:38:54Z NK cells: A double edge sword against SARS-CoV-2 Masselli, E. Vaccarezza, Mauro Carubbi, C. Pozzi, G. Presta, V. Mirandola, P. Vitale, M. © 2020 Elsevier Ltd Natural killer (NK) cells are pivotal effectors of the innate immunity protecting an individual from microbes. They are the first line of defense against invading viruses, given their substantial ability to directly target infected cells without the need for specific antigen presentation. By establishing cellular networks with a variety of cell types such as dendritic cells, NK cells can also amplify and modulate antiviral adaptive immune responses. In this review, we will examine the role of NK cells in SARS-COV2 infections causing the ongoing COVID19 pandemic, keeping in mind the controversial role of NK cells specifically in viral respiratory infections and in inflammatory-driven lung damage. We discuss lessons learnt from previous coronavirus outbreaks in humans (caused by SARS-CoV-1 and MERS-COV). 2020 Journal Article http://hdl.handle.net/20.500.11937/80200 10.1016/j.jbior.2020.100737 restricted |
| spellingShingle | Masselli, E. Vaccarezza, Mauro Carubbi, C. Pozzi, G. Presta, V. Mirandola, P. Vitale, M. NK cells: A double edge sword against SARS-CoV-2 |
| title | NK cells: A double edge sword against SARS-CoV-2 |
| title_full | NK cells: A double edge sword against SARS-CoV-2 |
| title_fullStr | NK cells: A double edge sword against SARS-CoV-2 |
| title_full_unstemmed | NK cells: A double edge sword against SARS-CoV-2 |
| title_short | NK cells: A double edge sword against SARS-CoV-2 |
| title_sort | nk cells: a double edge sword against sars-cov-2 |
| url | http://hdl.handle.net/20.500.11937/80200 |