Age-related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk
Aim: Heart failure (HF) incidence increases markedly with age. We examined age-associated longitudinal change in cardiac structure and function, and their prediction by age and cardiovascular disease (CVD) risk factors, in a community-based cohort aged ≥60 years at increased CVD risk but without HF....
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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WILEY PERIODICALS, INC
2020
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| Subjects: | |
| Online Access: | http://purl.org/au-research/grants/nhmrc/559010 http://hdl.handle.net/20.500.11937/80053 |
| _version_ | 1848764150230024192 |
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| author | Gong, F.F. Coller, J.M. McGrady, M. Boffa, U. Shiel, L. Liew, D. Stewart, S. Owen, A.J. Krum, H. Reid, Christopher Prior, D.L. Campbell, D.J. |
| author_facet | Gong, F.F. Coller, J.M. McGrady, M. Boffa, U. Shiel, L. Liew, D. Stewart, S. Owen, A.J. Krum, H. Reid, Christopher Prior, D.L. Campbell, D.J. |
| author_sort | Gong, F.F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Aim: Heart failure (HF) incidence increases markedly with age. We examined age-associated longitudinal change in cardiac structure and function, and their prediction by age and cardiovascular disease (CVD) risk factors, in a community-based cohort aged ≥60 years at increased CVD risk but without HF.
Methods and results: CVD risk factors were recorded in 3065 participants who underwent a baseline echocardiographic examination, of whom 2358 attended a follow-up examination 3.8 [median, inter-quartile range (IQR) 3.5, 4.2] years later. Median age was 71 (IQR 67, 76) years and 55% of participants were male. Age was associated with longitudinal increase in left ventricular (LV) mass index (LVMI); decrease in LV volumes; increase in LV ejection fraction; decrease in mitral annular systolic velocity; decrease in diastolic function (decreased mitral early diastolic annular velocity (e′); and increase in left atrial volume index, mitral peak early diastolic flow velocity (E)/e′ ratio, and tricuspid regurgitant velocity (TRVmax) in men and women, except for TRVmax in men). In multivariable analysis, longitudinal increase in LVMI was explained by CVD risk factors alone, whereas age, together with CVD risk factors, independently predicted longitudinal change in all other echocardiographic parameters. CVD risk factors were differentially associated with longitudinal change in different echocardiographic parameters.
Conclusions: Whereas the increase in LVMI with age was explained by CVD risk factors alone, age, together with risk factors, independently predicted longitudinal change in all other echocardiographic parameters, providing evidence for age-specific mechanisms of change in cardiac structure and function as people age. Age-associated change in LVMI, LV volumes, and diastolic function resembled what might be expected for the evolution of HF with preserved ejection fraction. Given the differential association of different CVD risk factors with longitudinal change in different echocardiographic parameters, therapies aimed at attenuation of age-associated change in cardiac structure and function, and HF evolution, will likely need to address multiple CVD risk factors. |
| first_indexed | 2025-11-14T11:14:47Z |
| format | Journal Article |
| id | curtin-20.500.11937-80053 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:14:47Z |
| publishDate | 2020 |
| publisher | WILEY PERIODICALS, INC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-800532021-01-05T08:07:08Z Age-related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk Gong, F.F. Coller, J.M. McGrady, M. Boffa, U. Shiel, L. Liew, D. Stewart, S. Owen, A.J. Krum, H. Reid, Christopher Prior, D.L. Campbell, D.J. Science & Technology Life Sciences & Biomedicine Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Heart failure Aging Risk factors Echocardiography VENTRICULAR DIASTOLIC FUNCTION END-POINT REDUCTION HEART-FAILURE EUROPEAN-ASSOCIATION AMERICAN-SOCIETY CHAMBER QUANTIFICATION LOSARTAN INTERVENTION ECHOCARDIOGRAPHY RECOMMENDATIONS HYPERTENSION Aim: Heart failure (HF) incidence increases markedly with age. We examined age-associated longitudinal change in cardiac structure and function, and their prediction by age and cardiovascular disease (CVD) risk factors, in a community-based cohort aged ≥60 years at increased CVD risk but without HF. Methods and results: CVD risk factors were recorded in 3065 participants who underwent a baseline echocardiographic examination, of whom 2358 attended a follow-up examination 3.8 [median, inter-quartile range (IQR) 3.5, 4.2] years later. Median age was 71 (IQR 67, 76) years and 55% of participants were male. Age was associated with longitudinal increase in left ventricular (LV) mass index (LVMI); decrease in LV volumes; increase in LV ejection fraction; decrease in mitral annular systolic velocity; decrease in diastolic function (decreased mitral early diastolic annular velocity (e′); and increase in left atrial volume index, mitral peak early diastolic flow velocity (E)/e′ ratio, and tricuspid regurgitant velocity (TRVmax) in men and women, except for TRVmax in men). In multivariable analysis, longitudinal increase in LVMI was explained by CVD risk factors alone, whereas age, together with CVD risk factors, independently predicted longitudinal change in all other echocardiographic parameters. CVD risk factors were differentially associated with longitudinal change in different echocardiographic parameters. Conclusions: Whereas the increase in LVMI with age was explained by CVD risk factors alone, age, together with risk factors, independently predicted longitudinal change in all other echocardiographic parameters, providing evidence for age-specific mechanisms of change in cardiac structure and function as people age. Age-associated change in LVMI, LV volumes, and diastolic function resembled what might be expected for the evolution of HF with preserved ejection fraction. Given the differential association of different CVD risk factors with longitudinal change in different echocardiographic parameters, therapies aimed at attenuation of age-associated change in cardiac structure and function, and HF evolution, will likely need to address multiple CVD risk factors. 2020 Journal Article http://hdl.handle.net/20.500.11937/80053 10.1002/ehf2.12687 English http://purl.org/au-research/grants/nhmrc/559010 http://purl.org/au-research/grants/nhmrc/1044619 http://purl.org/au-research/grants/nhmrc/395508 http://purl.org/au-research/grants/nhmrc/1092642 http://purl.org/au-research/grants/nhmrc/1045862 http://purl.org/au-research/grants/nhmrc/1136372 http://purl.org/au-research/grants/nhmrc/1041796 http://purl.org/au-research/grants/nhmrc/620241 http://purl.org/au-research/grants/nhmrc/519456 http://creativecommons.org/licenses/by/4.0/ WILEY PERIODICALS, INC fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Heart failure Aging Risk factors Echocardiography VENTRICULAR DIASTOLIC FUNCTION END-POINT REDUCTION HEART-FAILURE EUROPEAN-ASSOCIATION AMERICAN-SOCIETY CHAMBER QUANTIFICATION LOSARTAN INTERVENTION ECHOCARDIOGRAPHY RECOMMENDATIONS HYPERTENSION Gong, F.F. Coller, J.M. McGrady, M. Boffa, U. Shiel, L. Liew, D. Stewart, S. Owen, A.J. Krum, H. Reid, Christopher Prior, D.L. Campbell, D.J. Age-related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk |
| title | Age-related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk |
| title_full | Age-related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk |
| title_fullStr | Age-related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk |
| title_full_unstemmed | Age-related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk |
| title_short | Age-related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk |
| title_sort | age-related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk |
| topic | Science & Technology Life Sciences & Biomedicine Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Heart failure Aging Risk factors Echocardiography VENTRICULAR DIASTOLIC FUNCTION END-POINT REDUCTION HEART-FAILURE EUROPEAN-ASSOCIATION AMERICAN-SOCIETY CHAMBER QUANTIFICATION LOSARTAN INTERVENTION ECHOCARDIOGRAPHY RECOMMENDATIONS HYPERTENSION |
| url | http://purl.org/au-research/grants/nhmrc/559010 http://purl.org/au-research/grants/nhmrc/559010 http://purl.org/au-research/grants/nhmrc/559010 http://purl.org/au-research/grants/nhmrc/559010 http://purl.org/au-research/grants/nhmrc/559010 http://purl.org/au-research/grants/nhmrc/559010 http://purl.org/au-research/grants/nhmrc/559010 http://purl.org/au-research/grants/nhmrc/559010 http://purl.org/au-research/grants/nhmrc/559010 http://hdl.handle.net/20.500.11937/80053 |