The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and ado...

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Main Authors:	Middeldorp, C.M., Felix, J.F., Mahajan, A., Ahluwalia, T.S., Auvinen, J., Bartels, M., Bilbao, J.R., Bisgaard, H., Bønnelykke, K., Boomsma, D.I., Bradfield, J.P., Bustamante, M., Chen, Z., Curtin, J.A., Custovic, A., Smith, G.D., Davies, G.E., Duijts, L., Eastwood, Peter, Eliasen, A.U., Estivill, X., Evans, D.M., Fedko, I.O., Gauderman, W.J., Gilliland, F., Granell, R., Grant, S.F.A., Guxens, M., Hakonarson, H., Hartman, C.A., Heinrich, J., Henders, A.K., Henderson, J., Holt, P., Hottenga, J.J., Hyppönen, E., Iñíguez, C., Jacobsson, B., Jaddoe, V.W.V., Järvelin, M.R., Jugessur, A., Kähönen, M., Kaprio, J., Karhunen, V., Kemp, J.P., Koppelman, G.H., Kumar, A., Lahti, J., Larsson, H., Lawlor, D.A., Lehtimäki, T., Li, J., Lichtenstein, P., Lundström, S., Lyytikäinen, L.P., Magnus, P., Mamun, A.A., Mannikko, M., Martin, N.G., Mbarek, H., Medland, S.E., Melén, E., Najman, J.M., Nivard, M.G., Nolte, I.M., Oldehinkel, A.J., Pahkala, K., Palviainen, T., Paternoster, L., Pennell, C.E., Pershagen, G., Pitkänen, N., Plomin, R., Pourcain, B.S., Power, C., Pulkkinen, L., Räikkönen, K., Raitakari, O.T., Richmond, R.C., Rivadeneira, F., Rose, R.J., Santa-Marina, L., Scott, J.G., Sebert, S., Selzam, S., Simpson, A., Sleiman, P.M.A., Snieder, H., Standl, M., Stoltenberg, C., Strachan, D.P., Straker, Leon, Strandberg, T., Sunyer, J., Thiering, E., Tiemeier, H., Timpson, N.J., Torrent, M., Uitterlinden, A.G.
Format:	Journal Article
Language:	English
Published:	SPRINGER 2019
Subjects:	Science & Technology Life Sciences & Biomedicine Public, Environmental & Occupational Health Genetics Consortium Childhood traits and disorders Longitudinal GENOME-WIDE ASSOCIATION LD SCORE REGRESSION LONGITUDINAL TWIN CHILDHOOD OBESITY COMMON VARIANTS BLOOD-PRESSURE BIRTH-WEIGHT BODY-MASS LOCI METAANALYSIS
Online Access:	http://purl.org/au-research/grants/nhmrc/1104818 http://hdl.handle.net/20.500.11937/79990

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author	Middeldorp, C.M. Felix, J.F. Mahajan, A. Ahluwalia, T.S. Auvinen, J. Bartels, M. Bilbao, J.R. Bisgaard, H. Bønnelykke, K. Boomsma, D.I. Bradfield, J.P. Bustamante, M. Chen, Z. Curtin, J.A. Custovic, A. Smith, G.D. Davies, G.E. Duijts, L. Eastwood, Peter Eliasen, A.U. Estivill, X. Evans, D.M. Fedko, I.O. Gauderman, W.J. Gilliland, F. Granell, R. Grant, S.F.A. Guxens, M. Hakonarson, H. Hartman, C.A. Heinrich, J. Henders, A.K. Henderson, J. Holt, P. Hottenga, J.J. Hyppönen, E. Iñíguez, C. Jacobsson, B. Jaddoe, V.W.V. Järvelin, M.R. Jugessur, A. Kähönen, M. Kaprio, J. Karhunen, V. Kemp, J.P. Koppelman, G.H. Kumar, A. Lahti, J. Larsson, H. Lawlor, D.A. Lehtimäki, T. Li, J. Lichtenstein, P. Lundström, S. Lyytikäinen, L.P. Magnus, P. Mamun, A.A. Mannikko, M. Martin, N.G. Mbarek, H. Medland, S.E. Melén, E. Najman, J.M. Nivard, M.G. Nolte, I.M. Oldehinkel, A.J. Pahkala, K. Palviainen, T. Paternoster, L. Pennell, C.E. Pershagen, G. Pitkänen, N. Plomin, R. Pourcain, B.S. Power, C. Pulkkinen, L. Räikkönen, K. Raitakari, O.T. Richmond, R.C. Rivadeneira, F. Rose, R.J. Santa-Marina, L. Scott, J.G. Sebert, S. Selzam, S. Simpson, A. Sleiman, P.M.A. Snieder, H. Standl, M. Stoltenberg, C. Strachan, D.P. Straker, Leon Strandberg, T. Sunyer, J. Thiering, E. Tiemeier, H. Timpson, N.J. Torrent, M. Uitterlinden, A.G.
author_facet	Middeldorp, C.M. Felix, J.F. Mahajan, A. Ahluwalia, T.S. Auvinen, J. Bartels, M. Bilbao, J.R. Bisgaard, H. Bønnelykke, K. Boomsma, D.I. Bradfield, J.P. Bustamante, M. Chen, Z. Curtin, J.A. Custovic, A. Smith, G.D. Davies, G.E. Duijts, L. Eastwood, Peter Eliasen, A.U. Estivill, X. Evans, D.M. Fedko, I.O. Gauderman, W.J. Gilliland, F. Granell, R. Grant, S.F.A. Guxens, M. Hakonarson, H. Hartman, C.A. Heinrich, J. Henders, A.K. Henderson, J. Holt, P. Hottenga, J.J. Hyppönen, E. Iñíguez, C. Jacobsson, B. Jaddoe, V.W.V. Järvelin, M.R. Jugessur, A. Kähönen, M. Kaprio, J. Karhunen, V. Kemp, J.P. Koppelman, G.H. Kumar, A. Lahti, J. Larsson, H. Lawlor, D.A. Lehtimäki, T. Li, J. Lichtenstein, P. Lundström, S. Lyytikäinen, L.P. Magnus, P. Mamun, A.A. Mannikko, M. Martin, N.G. Mbarek, H. Medland, S.E. Melén, E. Najman, J.M. Nivard, M.G. Nolte, I.M. Oldehinkel, A.J. Pahkala, K. Palviainen, T. Paternoster, L. Pennell, C.E. Pershagen, G. Pitkänen, N. Plomin, R. Pourcain, B.S. Power, C. Pulkkinen, L. Räikkönen, K. Raitakari, O.T. Richmond, R.C. Rivadeneira, F. Rose, R.J. Santa-Marina, L. Scott, J.G. Sebert, S. Selzam, S. Simpson, A. Sleiman, P.M.A. Snieder, H. Standl, M. Stoltenberg, C. Strachan, D.P. Straker, Leon Strandberg, T. Sunyer, J. Thiering, E. Tiemeier, H. Timpson, N.J. Torrent, M. Uitterlinden, A.G.
author_sort	Middeldorp, C.M.
building	Curtin Institutional Repository
collection	Online Access
description	The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
first_indexed	2025-11-14T11:14:35Z
format	Journal Article
id	curtin-20.500.11937-79990
institution	Curtin University Malaysia
institution_category	Local University
language	English
last_indexed	2025-11-14T11:14:35Z
publishDate	2019
publisher	SPRINGER
recordtype	eprints
repository_type	Digital Repository
spelling	curtin-20.500.11937-799902021-01-08T07:54:28Z The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects Middeldorp, C.M. Felix, J.F. Mahajan, A. Ahluwalia, T.S. Auvinen, J. Bartels, M. Bilbao, J.R. Bisgaard, H. Bønnelykke, K. Boomsma, D.I. Bradfield, J.P. Bustamante, M. Chen, Z. Curtin, J.A. Custovic, A. Smith, G.D. Davies, G.E. Duijts, L. Eastwood, Peter Eliasen, A.U. Estivill, X. Evans, D.M. Fedko, I.O. Gauderman, W.J. Gilliland, F. Granell, R. Grant, S.F.A. Guxens, M. Hakonarson, H. Hartman, C.A. Heinrich, J. Henders, A.K. Henderson, J. Holt, P. Hottenga, J.J. Hyppönen, E. Iñíguez, C. Jacobsson, B. Jaddoe, V.W.V. Järvelin, M.R. Jugessur, A. Kähönen, M. Kaprio, J. Karhunen, V. Kemp, J.P. Koppelman, G.H. Kumar, A. Lahti, J. Larsson, H. Lawlor, D.A. Lehtimäki, T. Li, J. Lichtenstein, P. Lundström, S. Lyytikäinen, L.P. Magnus, P. Mamun, A.A. Mannikko, M. Martin, N.G. Mbarek, H. Medland, S.E. Melén, E. Najman, J.M. Nivard, M.G. Nolte, I.M. Oldehinkel, A.J. Pahkala, K. Palviainen, T. Paternoster, L. Pennell, C.E. Pershagen, G. Pitkänen, N. Plomin, R. Pourcain, B.S. Power, C. Pulkkinen, L. Räikkönen, K. Raitakari, O.T. Richmond, R.C. Rivadeneira, F. Rose, R.J. Santa-Marina, L. Scott, J.G. Sebert, S. Selzam, S. Simpson, A. Sleiman, P.M.A. Snieder, H. Standl, M. Stoltenberg, C. Strachan, D.P. Straker, Leon Strandberg, T. Sunyer, J. Thiering, E. Tiemeier, H. Timpson, N.J. Torrent, M. Uitterlinden, A.G. Science & Technology Life Sciences & Biomedicine Public, Environmental & Occupational Health Genetics Consortium Childhood traits and disorders Longitudinal GENOME-WIDE ASSOCIATION LD SCORE REGRESSION LONGITUDINAL TWIN CHILDHOOD OBESITY COMMON VARIANTS BLOOD-PRESSURE BIRTH-WEIGHT BODY-MASS LOCI METAANALYSIS The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites. 2019 Journal Article http://hdl.handle.net/20.500.11937/79990 10.1007/s10654-019-00502-9 English http://purl.org/au-research/grants/nhmrc/1104818 http://purl.org/au-research/grants/nhmrc/1105807 http://purl.org/au-research/grants/nhmrc/1137714 http://purl.org/au-research/grants/nhmrc/572613 http://purl.org/au-research/grants/nhmrc/403981 http://purl.org/au-research/grants/arc/FT130101709 http://purl.org/au-research/grants/arc/DP0212016 http://creativecommons.org/licenses/by/4.0/ SPRINGER fulltext
spellingShingle	Science & Technology Life Sciences & Biomedicine Public, Environmental & Occupational Health Genetics Consortium Childhood traits and disorders Longitudinal GENOME-WIDE ASSOCIATION LD SCORE REGRESSION LONGITUDINAL TWIN CHILDHOOD OBESITY COMMON VARIANTS BLOOD-PRESSURE BIRTH-WEIGHT BODY-MASS LOCI METAANALYSIS Middeldorp, C.M. Felix, J.F. Mahajan, A. Ahluwalia, T.S. Auvinen, J. Bartels, M. Bilbao, J.R. Bisgaard, H. Bønnelykke, K. Boomsma, D.I. Bradfield, J.P. Bustamante, M. Chen, Z. Curtin, J.A. Custovic, A. Smith, G.D. Davies, G.E. Duijts, L. Eastwood, Peter Eliasen, A.U. Estivill, X. Evans, D.M. Fedko, I.O. Gauderman, W.J. Gilliland, F. Granell, R. Grant, S.F.A. Guxens, M. Hakonarson, H. Hartman, C.A. Heinrich, J. Henders, A.K. Henderson, J. Holt, P. Hottenga, J.J. Hyppönen, E. Iñíguez, C. Jacobsson, B. Jaddoe, V.W.V. Järvelin, M.R. Jugessur, A. Kähönen, M. Kaprio, J. Karhunen, V. Kemp, J.P. Koppelman, G.H. Kumar, A. Lahti, J. Larsson, H. Lawlor, D.A. Lehtimäki, T. Li, J. Lichtenstein, P. Lundström, S. Lyytikäinen, L.P. Magnus, P. Mamun, A.A. Mannikko, M. Martin, N.G. Mbarek, H. Medland, S.E. Melén, E. Najman, J.M. Nivard, M.G. Nolte, I.M. Oldehinkel, A.J. Pahkala, K. Palviainen, T. Paternoster, L. Pennell, C.E. Pershagen, G. Pitkänen, N. Plomin, R. Pourcain, B.S. Power, C. Pulkkinen, L. Räikkönen, K. Raitakari, O.T. Richmond, R.C. Rivadeneira, F. Rose, R.J. Santa-Marina, L. Scott, J.G. Sebert, S. Selzam, S. Simpson, A. Sleiman, P.M.A. Snieder, H. Standl, M. Stoltenberg, C. Strachan, D.P. Straker, Leon Strandberg, T. Sunyer, J. Thiering, E. Tiemeier, H. Timpson, N.J. Torrent, M. Uitterlinden, A.G. The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
title	The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
title_full	The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
title_fullStr	The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
title_full_unstemmed	The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
title_short	The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
title_sort	early growth genetics (egg) and early genetics and lifecourse epidemiology (eagle) consortia: design, results and future prospects
topic	Science & Technology Life Sciences & Biomedicine Public, Environmental & Occupational Health Genetics Consortium Childhood traits and disorders Longitudinal GENOME-WIDE ASSOCIATION LD SCORE REGRESSION LONGITUDINAL TWIN CHILDHOOD OBESITY COMMON VARIANTS BLOOD-PRESSURE BIRTH-WEIGHT BODY-MASS LOCI METAANALYSIS
url	http://purl.org/au-research/grants/nhmrc/1104818 http://purl.org/au-research/grants/nhmrc/1104818 http://purl.org/au-research/grants/nhmrc/1104818 http://purl.org/au-research/grants/nhmrc/1104818 http://purl.org/au-research/grants/nhmrc/1104818 http://purl.org/au-research/grants/nhmrc/1104818 http://purl.org/au-research/grants/nhmrc/1104818 http://hdl.handle.net/20.500.11937/79990

The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

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