Western australian pregnancy cohort (raine) study: Generation 1
Purpose: The purpose of the Raine Study is to improve human health and well-being by studying the life-course of a cohort of Western Australians, based on a life-course conceptual framework that considers interactions between genetics, phenotypes, behaviours, the environment and developmental and so...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | English |
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2019
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| Online Access: | http://purl.org/au-research/grants/nhmrc/880441 http://hdl.handle.net/20.500.11937/79989 |
| _version_ | 1848764138258432000 |
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| author | Dontje, M.L. Eastwood, Peter Straker, Leon |
| author_facet | Dontje, M.L. Eastwood, Peter Straker, Leon |
| author_sort | Dontje, M.L. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Purpose: The purpose of the Raine Study is to improve human health and well-being by studying the life-course of a cohort of Western Australians, based on a life-course conceptual framework that considers interactions between genetics, phenotypes, behaviours, the environment and developmental and social outcomes.
Participants: Between May 1989 and November 1991, 2900 pregnant women were enrolled in the Raine Study in Perth, Western Australia. In total, 2730 women gave birth to 2868 children (Generation 2) between August 1989 and April 1992. The mothers and fathers of Generation 2 are referred to as Generation 1 of the Raine Study. In the most recent Generation 1 follow-up, 636 mothers and 462 fathers participated.
Findings to date: Until the 26-year follow-up of Generation 1 the focus of research within the Raine Study was on outcomes in Generation 2, with information on the parents mainly being used to examine its influence on their children's outcomes. For example, recent findings showed that several characteristics of mothers, such as obesity, early mid-gestational weight gain and socioeconomic status were associated with non-Alcoholic fatty liver disease, adiposity and cardiometabolic characteristics in offspring. Other findings showed that parents with back pain were more likely to have offspring who experienced back pain. Also, non-linear and dynamic relationships were found between maternal working hours and offspring overweight or obesity.
Future plans: The Raine Study will continue to provide access to its dense longitudinal genetic, phenotypic, behavioural, environmental, developmental and social data to undertake studies with the ultimate goal of improving human health and well-being. Analyses of data from the recent Generation 1 year 26 follow-up are underway.
Trial registration number ACTRN12617001599369 |
| first_indexed | 2025-11-14T11:14:35Z |
| format | Journal Article |
| id | curtin-20.500.11937-79989 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:14:35Z |
| publishDate | 2019 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-799892020-08-21T06:58:35Z Western australian pregnancy cohort (raine) study: Generation 1 Dontje, M.L. Eastwood, Peter Straker, Leon Raine Study health life-course longitudinal multi-generational observational pregnancy Adult Female Follow-Up Studies Humans Longitudinal Studies Mothers Population Surveillance Pregnancy Prospective Studies Socioeconomic Factors Surveys and Questionnaires Western Australia Young Adult Purpose: The purpose of the Raine Study is to improve human health and well-being by studying the life-course of a cohort of Western Australians, based on a life-course conceptual framework that considers interactions between genetics, phenotypes, behaviours, the environment and developmental and social outcomes. Participants: Between May 1989 and November 1991, 2900 pregnant women were enrolled in the Raine Study in Perth, Western Australia. In total, 2730 women gave birth to 2868 children (Generation 2) between August 1989 and April 1992. The mothers and fathers of Generation 2 are referred to as Generation 1 of the Raine Study. In the most recent Generation 1 follow-up, 636 mothers and 462 fathers participated. Findings to date: Until the 26-year follow-up of Generation 1 the focus of research within the Raine Study was on outcomes in Generation 2, with information on the parents mainly being used to examine its influence on their children's outcomes. For example, recent findings showed that several characteristics of mothers, such as obesity, early mid-gestational weight gain and socioeconomic status were associated with non-Alcoholic fatty liver disease, adiposity and cardiometabolic characteristics in offspring. Other findings showed that parents with back pain were more likely to have offspring who experienced back pain. Also, non-linear and dynamic relationships were found between maternal working hours and offspring overweight or obesity. Future plans: The Raine Study will continue to provide access to its dense longitudinal genetic, phenotypic, behavioural, environmental, developmental and social data to undertake studies with the ultimate goal of improving human health and well-being. Analyses of data from the recent Generation 1 year 26 follow-up are underway. Trial registration number ACTRN12617001599369 2019 Journal Article http://hdl.handle.net/20.500.11937/79989 10.1136/bmjopen-2018-026276 eng http://purl.org/au-research/grants/nhmrc/880441 http://purl.org/au-research/grants/nhmrc/930745 http://purl.org/au-research/grants/nhmrc/963209 http://purl.org/au-research/grants/nhmrc/211912 http://purl.org/au-research/grants/nhmrc/003209 http://purl.org/au-research/grants/nhmrc/32300 http://purl.org/au-research/grants/nhmrc/403981 http://purl.org/au-research/grants/nhmrc/353514 http://purl.org/au-research/grants/nhmrc/458623 http://purl.org/au-research/grants/nhmrc/403968 http://purl.org/au-research/grants/nhmrc/572613 http://purl.org/au-research/grants/nhmrc/1084947 http://purl.org/au-research/grants/nhmrc/1080492 http://creativecommons.org/licenses/by-nc/4.0/ fulltext |
| spellingShingle | Raine Study health life-course longitudinal multi-generational observational pregnancy Adult Female Follow-Up Studies Humans Longitudinal Studies Mothers Population Surveillance Pregnancy Prospective Studies Socioeconomic Factors Surveys and Questionnaires Western Australia Young Adult Dontje, M.L. Eastwood, Peter Straker, Leon Western australian pregnancy cohort (raine) study: Generation 1 |
| title | Western australian pregnancy cohort (raine) study: Generation 1 |
| title_full | Western australian pregnancy cohort (raine) study: Generation 1 |
| title_fullStr | Western australian pregnancy cohort (raine) study: Generation 1 |
| title_full_unstemmed | Western australian pregnancy cohort (raine) study: Generation 1 |
| title_short | Western australian pregnancy cohort (raine) study: Generation 1 |
| title_sort | western australian pregnancy cohort (raine) study: generation 1 |
| topic | Raine Study health life-course longitudinal multi-generational observational pregnancy Adult Female Follow-Up Studies Humans Longitudinal Studies Mothers Population Surveillance Pregnancy Prospective Studies Socioeconomic Factors Surveys and Questionnaires Western Australia Young Adult |
| url | http://purl.org/au-research/grants/nhmrc/880441 http://purl.org/au-research/grants/nhmrc/880441 http://purl.org/au-research/grants/nhmrc/880441 http://purl.org/au-research/grants/nhmrc/880441 http://purl.org/au-research/grants/nhmrc/880441 http://purl.org/au-research/grants/nhmrc/880441 http://purl.org/au-research/grants/nhmrc/880441 http://purl.org/au-research/grants/nhmrc/880441 http://purl.org/au-research/grants/nhmrc/880441 http://purl.org/au-research/grants/nhmrc/880441 http://purl.org/au-research/grants/nhmrc/880441 http://purl.org/au-research/grants/nhmrc/880441 http://purl.org/au-research/grants/nhmrc/880441 http://hdl.handle.net/20.500.11937/79989 |