Inflammatory bowel disease: clinical aspects and treatments
Inflammatory bowel disease (IBD) is defined as a chronic intestinal inflammation that results from host-microbial interactions in a genetically susceptible individual. IBDs are a group of autoimmune diseases that are characterized by inflammation of both the small and large intestine, in which eleme...
| Main Authors: | , , , |
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| Format: | Journal Article |
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Dove Medical Press Ltd.
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/7975 |
| _version_ | 1848745523673038848 |
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| author | Fakhoury, M. Negrulj, Rebecca Mooranian, Armin Al-Salami, Hani |
| author_facet | Fakhoury, M. Negrulj, Rebecca Mooranian, Armin Al-Salami, Hani |
| author_sort | Fakhoury, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Inflammatory bowel disease (IBD) is defined as a chronic intestinal inflammation that results from host-microbial interactions in a genetically susceptible individual. IBDs are a group of autoimmune diseases that are characterized by inflammation of both the small and large intestine, in which elements of the digestive system are attacked by the body's own immune system. This inflammatory condition encompasses two major forms, known as Crohn's disease and ulcerative colitis. Patients affected by these diseases experience abdominal symptoms, including diarrhea, abdominal pain, bloody stools, and vomiting. Moreover, defects in intestinal epithelial barrier function have been observed in a number of patients affected by IBD. In this review, we first describe the types and symptoms of IBD and investigate the role that the epithelial barrier plays in the pathophysiology of IBD as well as the major cytokines involved. We then discuss steps used to diagnose this disease and the treatment options available, and finally provide an overview of the recent research that aims to develop new therapies for such chronic disorders. |
| first_indexed | 2025-11-14T06:18:43Z |
| format | Journal Article |
| id | curtin-20.500.11937-7975 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:18:43Z |
| publishDate | 2014 |
| publisher | Dove Medical Press Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-79752017-09-13T14:33:47Z Inflammatory bowel disease: clinical aspects and treatments Fakhoury, M. Negrulj, Rebecca Mooranian, Armin Al-Salami, Hani cytokines ulcerative colitis Crohn’s disease inflammatory bowel disease Inflammatory bowel disease (IBD) is defined as a chronic intestinal inflammation that results from host-microbial interactions in a genetically susceptible individual. IBDs are a group of autoimmune diseases that are characterized by inflammation of both the small and large intestine, in which elements of the digestive system are attacked by the body's own immune system. This inflammatory condition encompasses two major forms, known as Crohn's disease and ulcerative colitis. Patients affected by these diseases experience abdominal symptoms, including diarrhea, abdominal pain, bloody stools, and vomiting. Moreover, defects in intestinal epithelial barrier function have been observed in a number of patients affected by IBD. In this review, we first describe the types and symptoms of IBD and investigate the role that the epithelial barrier plays in the pathophysiology of IBD as well as the major cytokines involved. We then discuss steps used to diagnose this disease and the treatment options available, and finally provide an overview of the recent research that aims to develop new therapies for such chronic disorders. 2014 Journal Article http://hdl.handle.net/20.500.11937/7975 10.2147/JIR.S65979 Dove Medical Press Ltd. fulltext |
| spellingShingle | cytokines ulcerative colitis Crohn’s disease inflammatory bowel disease Fakhoury, M. Negrulj, Rebecca Mooranian, Armin Al-Salami, Hani Inflammatory bowel disease: clinical aspects and treatments |
| title | Inflammatory bowel disease: clinical aspects and treatments |
| title_full | Inflammatory bowel disease: clinical aspects and treatments |
| title_fullStr | Inflammatory bowel disease: clinical aspects and treatments |
| title_full_unstemmed | Inflammatory bowel disease: clinical aspects and treatments |
| title_short | Inflammatory bowel disease: clinical aspects and treatments |
| title_sort | inflammatory bowel disease: clinical aspects and treatments |
| topic | cytokines ulcerative colitis Crohn’s disease inflammatory bowel disease |
| url | http://hdl.handle.net/20.500.11937/7975 |