Disruption of default mode network dynamics in acute and chronic pain states
© 2017 The Authors It has been proposed that pain competes with other attention-demanding stimuli for cognitive resources, and many chronic pain patients display significant attention and mental flexibility deficits. These alterations may result from disruptions in the functioning of the default mod...
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| Format: | Journal Article |
| Language: | English |
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ELSEVIER SCI LTD
2018
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| Online Access: | http://purl.org/au-research/grants/nhmrc/G160279 http://hdl.handle.net/20.500.11937/79563 |
| _version_ | 1848764074912907264 |
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| author | Alshelh, Z. Marciszewski, K.K. Akhter, R. Harrington, Flavia Mills, E.P. Vickers, E.R. Peck, C.C. Murray, G.M. Henderson, L.A. |
| author_facet | Alshelh, Z. Marciszewski, K.K. Akhter, R. Harrington, Flavia Mills, E.P. Vickers, E.R. Peck, C.C. Murray, G.M. Henderson, L.A. |
| author_sort | Alshelh, Z. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 The Authors It has been proposed that pain competes with other attention-demanding stimuli for cognitive resources, and many chronic pain patients display significant attention and mental flexibility deficits. These alterations may result from disruptions in the functioning of the default mode network (DMN) which plays a critical role in attention, memory, prospection and self-processing, and recent investigations have found alterations in DMN function in multiple chronic pain conditions. Whilst it has been proposed that these DMN alterations are a characteristic of pain that is chronic in nature, we recently reported altered oscillatory activity in the DMN during an acute, 5 minute noxious stimulus in healthy control subjects. We therefore hypothesize that altered DMN activity patterns will not be restricted to those in chronic pain but instead will also occur in healthy individuals during tonic noxious stimuli. We used functional magnetic resonance imaging to measure resting state infra-slow oscillatory activity and functional connectivity in patients with chronic orofacial pain at rest and in healthy controls during a 20-minute tonic pain stimulus. We found decreases in oscillatory activity in key regions of the DMN in patients with chronic pain, as well as in healthy controls during tonic pain in addition to changes in functional connectivity between the posterior cingulate cortex and areas of the DMN in both groups. The results show that similar alterations in DMN function occur in healthy individuals during acute noxious stimuli as well as in individuals with chronic pain. These DMN changes may reflect the presence of pain per se and may underlie alterations in attentional processes that occur in the presence of pain. |
| first_indexed | 2025-11-14T11:13:35Z |
| format | Journal Article |
| id | curtin-20.500.11937-79563 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:13:35Z |
| publishDate | 2018 |
| publisher | ELSEVIER SCI LTD |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-795632021-01-08T07:54:27Z Disruption of default mode network dynamics in acute and chronic pain states Alshelh, Z. Marciszewski, K.K. Akhter, R. Harrington, Flavia Mills, E.P. Vickers, E.R. Peck, C.C. Murray, G.M. Henderson, L.A. Science & Technology Life Sciences & Biomedicine Neuroimaging Neurosciences & Neurology Precuneus Posterior cingulate cortex Attention Prefrontal cortex Chronic orofacial pain Functional magnetic resonance imaging POSTERIOR CINGULATE CORTEX FUNCTIONAL CONNECTIVITY ALZHEIMERS-DISEASE NEUROPATHIC PAIN COGNITIVE TASK BRAIN ACTIVITY CLINICAL PAIN ATTENTION PERFORMANCE ACTIVATION © 2017 The Authors It has been proposed that pain competes with other attention-demanding stimuli for cognitive resources, and many chronic pain patients display significant attention and mental flexibility deficits. These alterations may result from disruptions in the functioning of the default mode network (DMN) which plays a critical role in attention, memory, prospection and self-processing, and recent investigations have found alterations in DMN function in multiple chronic pain conditions. Whilst it has been proposed that these DMN alterations are a characteristic of pain that is chronic in nature, we recently reported altered oscillatory activity in the DMN during an acute, 5 minute noxious stimulus in healthy control subjects. We therefore hypothesize that altered DMN activity patterns will not be restricted to those in chronic pain but instead will also occur in healthy individuals during tonic noxious stimuli. We used functional magnetic resonance imaging to measure resting state infra-slow oscillatory activity and functional connectivity in patients with chronic orofacial pain at rest and in healthy controls during a 20-minute tonic pain stimulus. We found decreases in oscillatory activity in key regions of the DMN in patients with chronic pain, as well as in healthy controls during tonic pain in addition to changes in functional connectivity between the posterior cingulate cortex and areas of the DMN in both groups. The results show that similar alterations in DMN function occur in healthy individuals during acute noxious stimuli as well as in individuals with chronic pain. These DMN changes may reflect the presence of pain per se and may underlie alterations in attentional processes that occur in the presence of pain. 2018 Journal Article http://hdl.handle.net/20.500.11937/79563 10.1016/j.nicl.2017.10.019 English http://purl.org/au-research/grants/nhmrc/G160279 http://purl.org/au-research/grants/nhmrc/G182968 http://creativecommons.org/licenses/by/4.0/ ELSEVIER SCI LTD fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Neuroimaging Neurosciences & Neurology Precuneus Posterior cingulate cortex Attention Prefrontal cortex Chronic orofacial pain Functional magnetic resonance imaging POSTERIOR CINGULATE CORTEX FUNCTIONAL CONNECTIVITY ALZHEIMERS-DISEASE NEUROPATHIC PAIN COGNITIVE TASK BRAIN ACTIVITY CLINICAL PAIN ATTENTION PERFORMANCE ACTIVATION Alshelh, Z. Marciszewski, K.K. Akhter, R. Harrington, Flavia Mills, E.P. Vickers, E.R. Peck, C.C. Murray, G.M. Henderson, L.A. Disruption of default mode network dynamics in acute and chronic pain states |
| title | Disruption of default mode network dynamics in acute and chronic pain states |
| title_full | Disruption of default mode network dynamics in acute and chronic pain states |
| title_fullStr | Disruption of default mode network dynamics in acute and chronic pain states |
| title_full_unstemmed | Disruption of default mode network dynamics in acute and chronic pain states |
| title_short | Disruption of default mode network dynamics in acute and chronic pain states |
| title_sort | disruption of default mode network dynamics in acute and chronic pain states |
| topic | Science & Technology Life Sciences & Biomedicine Neuroimaging Neurosciences & Neurology Precuneus Posterior cingulate cortex Attention Prefrontal cortex Chronic orofacial pain Functional magnetic resonance imaging POSTERIOR CINGULATE CORTEX FUNCTIONAL CONNECTIVITY ALZHEIMERS-DISEASE NEUROPATHIC PAIN COGNITIVE TASK BRAIN ACTIVITY CLINICAL PAIN ATTENTION PERFORMANCE ACTIVATION |
| url | http://purl.org/au-research/grants/nhmrc/G160279 http://purl.org/au-research/grants/nhmrc/G160279 http://hdl.handle.net/20.500.11937/79563 |