The relationship between thalamic GABA content and resting cortical rhythm in neuropathic pain
© 2018 Wiley Periodicals, Inc. Recurrent thalamocortical connections are integral to the generation of brain rhythms and it is thought that the inhibitory action of the thalamic reticular nucleus is critical in setting these rhythms. Our work and others' has suggested that chronic pain th...
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| Format: | Journal Article |
| Language: | English |
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WILEY
2018
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| Online Access: | http://purl.org/au-research/grants/nhmrc/G160279 http://hdl.handle.net/20.500.11937/79559 |
| _version_ | 1848764073759473664 |
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| author | Di Pietro, Flavia Macey, P.M. Rae, C.D. Alshelh, Z. Macefield, V.G. Vickers, E.R. Henderson, L.A. |
| author_facet | Di Pietro, Flavia Macey, P.M. Rae, C.D. Alshelh, Z. Macefield, V.G. Vickers, E.R. Henderson, L.A. |
| author_sort | Di Pietro, Flavia |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 Wiley Periodicals, Inc.
Recurrent thalamocortical connections are integral to the generation of brain rhythms and it is thought that the inhibitory action of the thalamic reticular nucleus is critical in setting these rhythms. Our work and others' has suggested that chronic pain that develops following nerve injury, that is, neuropathic pain, results from altered thalamocortical rhythm, although whether this dysrhythmia is associated with thalamic inhibitory function remains unknown. In this investigation, we used electroencephalography and magnetic resonance spectroscopy to investigate cortical power and thalamic GABAergic concentration in 20 patients with neuropathic pain and 20 pain-free controls. First, we found thalamocortical dysrhythmia in chronic orofacial neuropathic pain; patients displayed greater power than controls over the 4–25 Hz frequency range, most marked in the theta and low alpha bands. Furthermore, sensorimotor cortex displayed a strong positive correlation between cortical power and pain intensity. Interestingly, we found no difference in thalamic GABA concentration between pain subjects and control subjects. However, we demonstrated significant linear relationships between thalamic GABA concentration and enhanced cortical power in pain subjects but not controls. Whilst the difference in relationship between thalamic GABA concentration and resting brain rhythm between chronic pain and control subjects does not prove a cause and effect link, it is consistent with a role for thalamic inhibitory neurotransmitter release, possibly from the thalamic reticular nucleus, in altered brain rhythms in individuals with chronic neuropathic pain. |
| first_indexed | 2025-11-14T11:13:34Z |
| format | Journal Article |
| id | curtin-20.500.11937-79559 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:13:34Z |
| publishDate | 2018 |
| publisher | WILEY |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-795592020-09-04T05:53:10Z The relationship between thalamic GABA content and resting cortical rhythm in neuropathic pain Di Pietro, Flavia Macey, P.M. Rae, C.D. Alshelh, Z. Macefield, V.G. Vickers, E.R. Henderson, L.A. Science & Technology Life Sciences & Biomedicine Neurosciences Neuroimaging Radiology, Nuclear Medicine & Medical Imaging Neurosciences & Neurology chronic pain electroencephalography GABA thalamocortical rhythm SPINAL-CORD-INJURY NUCLEUS-RETICULARIS THALAMI THALAMOCORTICAL DYSRHYTHMIA NETWORK PROPERTIES NEUROGENIC PAIN NEURONS RATS PALMITOYLETHANOLAMIDE INHIBITION MECHANISMS © 2018 Wiley Periodicals, Inc. Recurrent thalamocortical connections are integral to the generation of brain rhythms and it is thought that the inhibitory action of the thalamic reticular nucleus is critical in setting these rhythms. Our work and others' has suggested that chronic pain that develops following nerve injury, that is, neuropathic pain, results from altered thalamocortical rhythm, although whether this dysrhythmia is associated with thalamic inhibitory function remains unknown. In this investigation, we used electroencephalography and magnetic resonance spectroscopy to investigate cortical power and thalamic GABAergic concentration in 20 patients with neuropathic pain and 20 pain-free controls. First, we found thalamocortical dysrhythmia in chronic orofacial neuropathic pain; patients displayed greater power than controls over the 4–25 Hz frequency range, most marked in the theta and low alpha bands. Furthermore, sensorimotor cortex displayed a strong positive correlation between cortical power and pain intensity. Interestingly, we found no difference in thalamic GABA concentration between pain subjects and control subjects. However, we demonstrated significant linear relationships between thalamic GABA concentration and enhanced cortical power in pain subjects but not controls. Whilst the difference in relationship between thalamic GABA concentration and resting brain rhythm between chronic pain and control subjects does not prove a cause and effect link, it is consistent with a role for thalamic inhibitory neurotransmitter release, possibly from the thalamic reticular nucleus, in altered brain rhythms in individuals with chronic neuropathic pain. 2018 Journal Article http://hdl.handle.net/20.500.11937/79559 10.1002/hbm.23973 English http://purl.org/au-research/grants/nhmrc/G160279 http://purl.org/au-research/grants/nhmrc/1091415 WILEY restricted |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Neurosciences Neuroimaging Radiology, Nuclear Medicine & Medical Imaging Neurosciences & Neurology chronic pain electroencephalography GABA thalamocortical rhythm SPINAL-CORD-INJURY NUCLEUS-RETICULARIS THALAMI THALAMOCORTICAL DYSRHYTHMIA NETWORK PROPERTIES NEUROGENIC PAIN NEURONS RATS PALMITOYLETHANOLAMIDE INHIBITION MECHANISMS Di Pietro, Flavia Macey, P.M. Rae, C.D. Alshelh, Z. Macefield, V.G. Vickers, E.R. Henderson, L.A. The relationship between thalamic GABA content and resting cortical rhythm in neuropathic pain |
| title | The relationship between thalamic GABA content and resting cortical rhythm in neuropathic pain |
| title_full | The relationship between thalamic GABA content and resting cortical rhythm in neuropathic pain |
| title_fullStr | The relationship between thalamic GABA content and resting cortical rhythm in neuropathic pain |
| title_full_unstemmed | The relationship between thalamic GABA content and resting cortical rhythm in neuropathic pain |
| title_short | The relationship between thalamic GABA content and resting cortical rhythm in neuropathic pain |
| title_sort | relationship between thalamic gaba content and resting cortical rhythm in neuropathic pain |
| topic | Science & Technology Life Sciences & Biomedicine Neurosciences Neuroimaging Radiology, Nuclear Medicine & Medical Imaging Neurosciences & Neurology chronic pain electroencephalography GABA thalamocortical rhythm SPINAL-CORD-INJURY NUCLEUS-RETICULARIS THALAMI THALAMOCORTICAL DYSRHYTHMIA NETWORK PROPERTIES NEUROGENIC PAIN NEURONS RATS PALMITOYLETHANOLAMIDE INHIBITION MECHANISMS |
| url | http://purl.org/au-research/grants/nhmrc/G160279 http://purl.org/au-research/grants/nhmrc/G160279 http://hdl.handle.net/20.500.11937/79559 |