Altered regional cerebral blood flow and hypothalamic connectivity immediately prior to a migraine headache
© International Headache Society 2020. Background: There is evidence of altered resting hypothalamic activity patterns and connectivity prior to a migraine, however it remains unknown if these changes are driven by changes in overall hypothalamic activity levels. If they are, it would corroborate th...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1032072 http://hdl.handle.net/20.500.11937/79554 |
| _version_ | 1848764072323973120 |
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| author | Meylakh, N. Marciszewski, K.K. Di Pietro, Flavia Macefield, V.G. Macey, P.M. Henderson, L.A. |
| author_facet | Meylakh, N. Marciszewski, K.K. Di Pietro, Flavia Macefield, V.G. Macey, P.M. Henderson, L.A. |
| author_sort | Meylakh, N. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © International Headache Society 2020. Background: There is evidence of altered resting hypothalamic activity patterns and connectivity prior to a migraine, however it remains unknown if these changes are driven by changes in overall hypothalamic activity levels. If they are, it would corroborate the idea that changes in hypothalamic function result in alteration in brainstem pain processing sensitivity, which either triggers a migraine headache itself or allows an external trigger to initiate a migraine headache. We hypothesise that hypothalamic activity increases immediately prior to a migraine headache and this is accompanied by altered functional connectivity to pain processing sites in the brainstem. Methods: In 34 migraineurs and 26 healthy controls, we collected a series comprising 108 pseudo-continuous arterial spin labelling images and 180 gradient-echo echo planar resting-state functional magnetic resonance volumes to measure resting regional cerebral blood flow and functional connectivity respectively. Images were pre-processed and analysed using custom SPM12 and Matlab software. Results: Our results reflect that immediately prior to a migraine headache, resting regional cerebral blood flow decreases in the lateral hypothalamus. In addition, resting functional connectivity strength decreased between the lateral hypothalamus and important regions of the pain processing pathway, such as the midbrain periaqueductal gray, dorsal pons, rostral ventromedial medulla and cingulate cortex, only during this critical period before a migraine headache. Conclusion: These data suggest altered hypothalamic function and connectivity in the period immediately prior to a migraine headache and supports the hypothesis that the hypothalamus is involved in migraine initiation. |
| first_indexed | 2025-11-14T11:13:32Z |
| format | Journal Article |
| id | curtin-20.500.11937-79554 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:13:32Z |
| publishDate | 2020 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-795542020-09-04T05:04:52Z Altered regional cerebral blood flow and hypothalamic connectivity immediately prior to a migraine headache Meylakh, N. Marciszewski, K.K. Di Pietro, Flavia Macefield, V.G. Macey, P.M. Henderson, L.A. Cerebral blood flow functional connectivity hypothalamus midbrain periaqueductal gray spinal trigeminal nucleus © International Headache Society 2020. Background: There is evidence of altered resting hypothalamic activity patterns and connectivity prior to a migraine, however it remains unknown if these changes are driven by changes in overall hypothalamic activity levels. If they are, it would corroborate the idea that changes in hypothalamic function result in alteration in brainstem pain processing sensitivity, which either triggers a migraine headache itself or allows an external trigger to initiate a migraine headache. We hypothesise that hypothalamic activity increases immediately prior to a migraine headache and this is accompanied by altered functional connectivity to pain processing sites in the brainstem. Methods: In 34 migraineurs and 26 healthy controls, we collected a series comprising 108 pseudo-continuous arterial spin labelling images and 180 gradient-echo echo planar resting-state functional magnetic resonance volumes to measure resting regional cerebral blood flow and functional connectivity respectively. Images were pre-processed and analysed using custom SPM12 and Matlab software. Results: Our results reflect that immediately prior to a migraine headache, resting regional cerebral blood flow decreases in the lateral hypothalamus. In addition, resting functional connectivity strength decreased between the lateral hypothalamus and important regions of the pain processing pathway, such as the midbrain periaqueductal gray, dorsal pons, rostral ventromedial medulla and cingulate cortex, only during this critical period before a migraine headache. Conclusion: These data suggest altered hypothalamic function and connectivity in the period immediately prior to a migraine headache and supports the hypothesis that the hypothalamus is involved in migraine initiation. 2020 Journal Article http://hdl.handle.net/20.500.11937/79554 10.1177/0333102420911623 eng http://purl.org/au-research/grants/nhmrc/1032072 http://purl.org/au-research/grants/nhmrc/1059182 restricted |
| spellingShingle | Cerebral blood flow functional connectivity hypothalamus midbrain periaqueductal gray spinal trigeminal nucleus Meylakh, N. Marciszewski, K.K. Di Pietro, Flavia Macefield, V.G. Macey, P.M. Henderson, L.A. Altered regional cerebral blood flow and hypothalamic connectivity immediately prior to a migraine headache |
| title | Altered regional cerebral blood flow and hypothalamic connectivity immediately prior to a migraine headache |
| title_full | Altered regional cerebral blood flow and hypothalamic connectivity immediately prior to a migraine headache |
| title_fullStr | Altered regional cerebral blood flow and hypothalamic connectivity immediately prior to a migraine headache |
| title_full_unstemmed | Altered regional cerebral blood flow and hypothalamic connectivity immediately prior to a migraine headache |
| title_short | Altered regional cerebral blood flow and hypothalamic connectivity immediately prior to a migraine headache |
| title_sort | altered regional cerebral blood flow and hypothalamic connectivity immediately prior to a migraine headache |
| topic | Cerebral blood flow functional connectivity hypothalamus midbrain periaqueductal gray spinal trigeminal nucleus |
| url | http://purl.org/au-research/grants/nhmrc/1032072 http://purl.org/au-research/grants/nhmrc/1032072 http://hdl.handle.net/20.500.11937/79554 |