Altered brainstem anatomy in migraine
© International Headache Society 2017. Background: The exact mechanisms responsible for migraine remain unknown, although it has been proposed that changes in brainstem anatomy and function, even between attacks, may contribute to the initiation and maintenance of headache during migraine attack...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | English |
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SAGE PUBLICATIONS LTD
2018
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/79551 |
| _version_ | 1848764071468335104 |
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| author | Marciszewski, K.K. Meylakh, N. Harrington, Flavia Macefield, V.G. Macey, P.M. Henderson, L.A. |
| author_facet | Marciszewski, K.K. Meylakh, N. Harrington, Flavia Macefield, V.G. Macey, P.M. Henderson, L.A. |
| author_sort | Marciszewski, K.K. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © International Headache Society 2017.
Background: The exact mechanisms responsible for migraine remain unknown, although it has been proposed that changes in brainstem anatomy and function, even between attacks, may contribute to the initiation and maintenance of headache during migraine attacks. The aim of this investigation is to use brainstem-specific analyses of anatomical and diffusion weighted images to determine if the trigeminal system displays altered structure in individuals with migraine.
Methods: Voxel-based morphometry of T1-weighted anatomical images (57 controls, 24 migraineurs) and diffusion tensor images (22 controls, 24 migraineurs) were used to assess brainstem anatomy in individuals with migraine compared with controls.
Results: We found grey matter volume decreases in migraineurs in the spinal trigeminal nucleus and dorsomedial pons. In addition, reduced grey matter volume and increased free water diffusivity occurred in areas of the descending pain modulatory system, including midbrain periaqueductal gray matter, dorsolateral pons, and medullary raphe. These changes were not correlated to migraine frequency, duration, intensity or time to next migraine. Conclusion: Brainstem anatomy changes may underlie changes in activity that result in activation of the ascending trigeminal pathway and the perception of head pain during a migraine attack. |
| first_indexed | 2025-11-14T11:13:31Z |
| format | Journal Article |
| id | curtin-20.500.11937-79551 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:13:31Z |
| publishDate | 2018 |
| publisher | SAGE PUBLICATIONS LTD |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-795512020-09-02T04:26:06Z Altered brainstem anatomy in migraine Marciszewski, K.K. Meylakh, N. Harrington, Flavia Macefield, V.G. Macey, P.M. Henderson, L.A. Science & Technology Life Sciences & Biomedicine Clinical Neurology Neurosciences Neurosciences & Neurology Spinal trigeminal nucleus grey matter volume periaqueductal gray matter hypothalamus diffusion tensor imaging CONDITIONED PAIN MODULATION RESONANCE-BASED MORPHOMETRY SUPERFICIAL DORSAL-HORN VOXEL-BASED MORPHOMETRY GREY-MATTER CHANGES NEUROPATHIC PAIN SENSORY INNERVATION CENTRAL PROJECTIONS NERVE INJURY LAMINA-II © International Headache Society 2017. Background: The exact mechanisms responsible for migraine remain unknown, although it has been proposed that changes in brainstem anatomy and function, even between attacks, may contribute to the initiation and maintenance of headache during migraine attacks. The aim of this investigation is to use brainstem-specific analyses of anatomical and diffusion weighted images to determine if the trigeminal system displays altered structure in individuals with migraine. Methods: Voxel-based morphometry of T1-weighted anatomical images (57 controls, 24 migraineurs) and diffusion tensor images (22 controls, 24 migraineurs) were used to assess brainstem anatomy in individuals with migraine compared with controls. Results: We found grey matter volume decreases in migraineurs in the spinal trigeminal nucleus and dorsomedial pons. In addition, reduced grey matter volume and increased free water diffusivity occurred in areas of the descending pain modulatory system, including midbrain periaqueductal gray matter, dorsolateral pons, and medullary raphe. These changes were not correlated to migraine frequency, duration, intensity or time to next migraine. Conclusion: Brainstem anatomy changes may underlie changes in activity that result in activation of the ascending trigeminal pathway and the perception of head pain during a migraine attack. 2018 Journal Article http://hdl.handle.net/20.500.11937/79551 10.1177/0333102417694884 English SAGE PUBLICATIONS LTD restricted |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Clinical Neurology Neurosciences Neurosciences & Neurology Spinal trigeminal nucleus grey matter volume periaqueductal gray matter hypothalamus diffusion tensor imaging CONDITIONED PAIN MODULATION RESONANCE-BASED MORPHOMETRY SUPERFICIAL DORSAL-HORN VOXEL-BASED MORPHOMETRY GREY-MATTER CHANGES NEUROPATHIC PAIN SENSORY INNERVATION CENTRAL PROJECTIONS NERVE INJURY LAMINA-II Marciszewski, K.K. Meylakh, N. Harrington, Flavia Macefield, V.G. Macey, P.M. Henderson, L.A. Altered brainstem anatomy in migraine |
| title | Altered brainstem anatomy in migraine |
| title_full | Altered brainstem anatomy in migraine |
| title_fullStr | Altered brainstem anatomy in migraine |
| title_full_unstemmed | Altered brainstem anatomy in migraine |
| title_short | Altered brainstem anatomy in migraine |
| title_sort | altered brainstem anatomy in migraine |
| topic | Science & Technology Life Sciences & Biomedicine Clinical Neurology Neurosciences Neurosciences & Neurology Spinal trigeminal nucleus grey matter volume periaqueductal gray matter hypothalamus diffusion tensor imaging CONDITIONED PAIN MODULATION RESONANCE-BASED MORPHOMETRY SUPERFICIAL DORSAL-HORN VOXEL-BASED MORPHOMETRY GREY-MATTER CHANGES NEUROPATHIC PAIN SENSORY INNERVATION CENTRAL PROJECTIONS NERVE INJURY LAMINA-II |
| url | http://hdl.handle.net/20.500.11937/79551 |