Imaging lipophilic regions in rodent brain tissue with halogenated BODIPY probes
The effect of halogen substitution in fluorescent BODIPY species was evaluated in the context of staining lipids in situ within brain tissue sections. Herein we demonstrate that the halogenated species maintain their known in vitro affinity when applied to detect lipids in situ in brain tissue secti...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | http://purl.org/au-research/grants/arc/FT190100017 http://hdl.handle.net/20.500.11937/79546 |
| _version_ | 1848764070003474432 |
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| author | Hartnell, David Schwehr, Bradley J Gillespie-Jones, Kate Alwis, Dasuni Rajan, Ramesh Hou, Huishu Sylvain, Nicole J Pushie, Michael J Kelly, Michael E Massi, Max Hackett, Mark |
| author_facet | Hartnell, David Schwehr, Bradley J Gillespie-Jones, Kate Alwis, Dasuni Rajan, Ramesh Hou, Huishu Sylvain, Nicole J Pushie, Michael J Kelly, Michael E Massi, Max Hackett, Mark |
| author_sort | Hartnell, David |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The effect of halogen substitution in fluorescent BODIPY species was evaluated in the context of staining lipids in situ within brain tissue sections. Herein we demonstrate that the halogenated species maintain their known in vitro affinity when applied to detect lipids in situ in brain tissue sections. Interestingly, the chlorine substituted compound revealed the highest specificify for white matter lipids. Furthermore, the halogen substituted compounds rapidly detected lipid enriched cells, in situ, associated with a case of brain pathology and neuroinflammation. |
| first_indexed | 2025-11-14T11:13:30Z |
| format | Journal Article |
| id | curtin-20.500.11937-79546 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:13:30Z |
| publishDate | 2020 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-795462023-02-02T03:24:10Z Imaging lipophilic regions in rodent brain tissue with halogenated BODIPY probes Hartnell, David Schwehr, Bradley J Gillespie-Jones, Kate Alwis, Dasuni Rajan, Ramesh Hou, Huishu Sylvain, Nicole J Pushie, Michael J Kelly, Michael E Massi, Max Hackett, Mark The effect of halogen substitution in fluorescent BODIPY species was evaluated in the context of staining lipids in situ within brain tissue sections. Herein we demonstrate that the halogenated species maintain their known in vitro affinity when applied to detect lipids in situ in brain tissue sections. Interestingly, the chlorine substituted compound revealed the highest specificify for white matter lipids. Furthermore, the halogen substituted compounds rapidly detected lipid enriched cells, in situ, associated with a case of brain pathology and neuroinflammation. 2020 Journal Article http://hdl.handle.net/20.500.11937/79546 10.1039/d0an00099j eng http://purl.org/au-research/grants/arc/FT190100017 restricted |
| spellingShingle | Hartnell, David Schwehr, Bradley J Gillespie-Jones, Kate Alwis, Dasuni Rajan, Ramesh Hou, Huishu Sylvain, Nicole J Pushie, Michael J Kelly, Michael E Massi, Max Hackett, Mark Imaging lipophilic regions in rodent brain tissue with halogenated BODIPY probes |
| title | Imaging lipophilic regions in rodent brain tissue with halogenated BODIPY probes |
| title_full | Imaging lipophilic regions in rodent brain tissue with halogenated BODIPY probes |
| title_fullStr | Imaging lipophilic regions in rodent brain tissue with halogenated BODIPY probes |
| title_full_unstemmed | Imaging lipophilic regions in rodent brain tissue with halogenated BODIPY probes |
| title_short | Imaging lipophilic regions in rodent brain tissue with halogenated BODIPY probes |
| title_sort | imaging lipophilic regions in rodent brain tissue with halogenated bodipy probes |
| url | http://purl.org/au-research/grants/arc/FT190100017 http://hdl.handle.net/20.500.11937/79546 |