Development of patient-specific 3D-printed breast phantom using silicone and peanut oils for magnetic resonance imaging
Background: Despite increasing reports of 3D printing in medical applications, the use of 3D printing in breast imaging is limited, thus, personalized 3D-printed breast model could be a novel approach to overcome current limitations in utilizing breast magnetic resonance imaging (MRI) for quantita...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
AME Publishing Company
2020
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| Subjects: | |
| Online Access: | https://creativecommons.org/licenses/by-nc-nd/4.0/ http://hdl.handle.net/20.500.11937/79504 |
| _version_ | 1848764063250644992 |
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| author | Sindi, Rooa Wong, Y.H. Yeong, C.H. Sun, Zhonghua |
| author_facet | Sindi, Rooa Wong, Y.H. Yeong, C.H. Sun, Zhonghua |
| author_sort | Sindi, Rooa |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Despite increasing reports of 3D printing in medical applications, the use of 3D printing in
breast imaging is limited, thus, personalized 3D-printed breast model could be a novel approach to overcome
current limitations in utilizing breast magnetic resonance imaging (MRI) for quantitative assessment of
breast density. The aim of this study is to develop a patient-specific 3D-printed breast phantom and to
identify the most appropriate materials for simulating the MR imaging characteristics of fibroglandular and
adipose tissues.
Methods: A patient-specific 3D-printed breast model was generated using 3D-printing techniques for
the construction of the hollow skin and fibroglandular region shells. Then, the T1 relaxation times of
the five selected materials (agarose gel, silicone rubber with/without fish oil, silicone oil, and peanut oil)
were measured on a 3T MRI system to determine the appropriate ones to represent the MR imaging
characteristics of fibroglandular and adipose tissues. Results were then compared to the reference values of
T1 relaxation times of the corresponding tissues: 1,324.42±167.63 and 449.27±26.09 ms, respectively. Finally,
the materials that matched the T1 relaxation times of the respective tissues were used to fill the 3D-printed
hollow breast shells.
Results: The silicone and peanut oils were found to closely resemble the T1 relaxation times and imaging
characteristics of these two tissues, which are 1,515.8±105.5 and 405.4±15.1 ms, respectively. The agarose gel
with different concentrations, ranging from 0.5 to 2.5 wt%, was found to have the longest T1 relaxation times.
Conclusions: A patient-specific 3D-printed breast phantom was successfully designed and constructed
using silicone and peanut oils to simulate the MR imaging characteristics of fibroglandular and adipose
tissues. The phantom can be used to investigate different MR breast imaging protocols for the quantitative
assessment of breast density. |
| first_indexed | 2025-11-14T11:13:24Z |
| format | Journal Article |
| id | curtin-20.500.11937-79504 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:13:24Z |
| publishDate | 2020 |
| publisher | AME Publishing Company |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-795042020-06-02T00:44:53Z Development of patient-specific 3D-printed breast phantom using silicone and peanut oils for magnetic resonance imaging Sindi, Rooa Wong, Y.H. Yeong, C.H. Sun, Zhonghua 1103 - Clinical Sciences Background: Despite increasing reports of 3D printing in medical applications, the use of 3D printing in breast imaging is limited, thus, personalized 3D-printed breast model could be a novel approach to overcome current limitations in utilizing breast magnetic resonance imaging (MRI) for quantitative assessment of breast density. The aim of this study is to develop a patient-specific 3D-printed breast phantom and to identify the most appropriate materials for simulating the MR imaging characteristics of fibroglandular and adipose tissues. Methods: A patient-specific 3D-printed breast model was generated using 3D-printing techniques for the construction of the hollow skin and fibroglandular region shells. Then, the T1 relaxation times of the five selected materials (agarose gel, silicone rubber with/without fish oil, silicone oil, and peanut oil) were measured on a 3T MRI system to determine the appropriate ones to represent the MR imaging characteristics of fibroglandular and adipose tissues. Results were then compared to the reference values of T1 relaxation times of the corresponding tissues: 1,324.42±167.63 and 449.27±26.09 ms, respectively. Finally, the materials that matched the T1 relaxation times of the respective tissues were used to fill the 3D-printed hollow breast shells. Results: The silicone and peanut oils were found to closely resemble the T1 relaxation times and imaging characteristics of these two tissues, which are 1,515.8±105.5 and 405.4±15.1 ms, respectively. The agarose gel with different concentrations, ranging from 0.5 to 2.5 wt%, was found to have the longest T1 relaxation times. Conclusions: A patient-specific 3D-printed breast phantom was successfully designed and constructed using silicone and peanut oils to simulate the MR imaging characteristics of fibroglandular and adipose tissues. The phantom can be used to investigate different MR breast imaging protocols for the quantitative assessment of breast density. 2020 Journal Article http://hdl.handle.net/20.500.11937/79504 10.21037/qims-20-251 https://creativecommons.org/licenses/by-nc-nd/4.0/ AME Publishing Company fulltext |
| spellingShingle | 1103 - Clinical Sciences Sindi, Rooa Wong, Y.H. Yeong, C.H. Sun, Zhonghua Development of patient-specific 3D-printed breast phantom using silicone and peanut oils for magnetic resonance imaging |
| title | Development of patient-specific 3D-printed breast phantom using silicone and peanut oils for magnetic resonance imaging |
| title_full | Development of patient-specific 3D-printed breast phantom using silicone and peanut oils for magnetic resonance imaging |
| title_fullStr | Development of patient-specific 3D-printed breast phantom using silicone and peanut oils for magnetic resonance imaging |
| title_full_unstemmed | Development of patient-specific 3D-printed breast phantom using silicone and peanut oils for magnetic resonance imaging |
| title_short | Development of patient-specific 3D-printed breast phantom using silicone and peanut oils for magnetic resonance imaging |
| title_sort | development of patient-specific 3d-printed breast phantom using silicone and peanut oils for magnetic resonance imaging |
| topic | 1103 - Clinical Sciences |
| url | https://creativecommons.org/licenses/by-nc-nd/4.0/ http://hdl.handle.net/20.500.11937/79504 |