Investigation of Novel Biomarkers for Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is a disease with dismal prognosis and an 8% chance of survival 5 years post-diagnosis, and is very challenging diagnostically and therapeutically. Exosomes are nanometre-sized vesicles known to mediate cancer spread and chemotherapy resistance. In this study,...
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| Format: | Thesis |
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Curtin University
2019
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| Online Access: | http://hdl.handle.net/20.500.11937/78328 |
| _version_ | 1848763960130535424 |
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| author | Emmanouilidi, Aikaterini |
| author_facet | Emmanouilidi, Aikaterini |
| author_sort | Emmanouilidi, Aikaterini |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Pancreatic ductal adenocarcinoma (PDAC) is a disease with dismal prognosis and an 8% chance of survival 5 years post-diagnosis, and is very challenging diagnostically and therapeutically. Exosomes are nanometre-sized vesicles known to mediate cancer spread and chemotherapy resistance. In this study, a comprehensive proteomic and lipidomic analysis of PDAC-derived exosomes has been performed. A specific enrichment of key signalling proteins and lipids with a potential role in PDAC progression has been identified. |
| first_indexed | 2025-11-14T11:11:45Z |
| format | Thesis |
| id | curtin-20.500.11937-78328 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:11:45Z |
| publishDate | 2019 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-783282022-03-21T06:32:42Z Investigation of Novel Biomarkers for Pancreatic Cancer Emmanouilidi, Aikaterini Pancreatic ductal adenocarcinoma (PDAC) is a disease with dismal prognosis and an 8% chance of survival 5 years post-diagnosis, and is very challenging diagnostically and therapeutically. Exosomes are nanometre-sized vesicles known to mediate cancer spread and chemotherapy resistance. In this study, a comprehensive proteomic and lipidomic analysis of PDAC-derived exosomes has been performed. A specific enrichment of key signalling proteins and lipids with a potential role in PDAC progression has been identified. 2019 Thesis http://hdl.handle.net/20.500.11937/78328 Curtin University fulltext |
| spellingShingle | Emmanouilidi, Aikaterini Investigation of Novel Biomarkers for Pancreatic Cancer |
| title | Investigation of Novel Biomarkers for Pancreatic Cancer |
| title_full | Investigation of Novel Biomarkers for Pancreatic Cancer |
| title_fullStr | Investigation of Novel Biomarkers for Pancreatic Cancer |
| title_full_unstemmed | Investigation of Novel Biomarkers for Pancreatic Cancer |
| title_short | Investigation of Novel Biomarkers for Pancreatic Cancer |
| title_sort | investigation of novel biomarkers for pancreatic cancer |
| url | http://hdl.handle.net/20.500.11937/78328 |