ADAM and ADAMTS Proteases in Hepatic Disorders
Proteolysis is an irreversible post-translational modification that regulates protein function and signal transduction. This includes remodelling of the extracellular matrix, release of membrane-bound cytokines and receptor ectodomains, as well as the initiation of intracellular signalling cues. Me...
| Main Authors: | , , |
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| Format: | Journal Article |
| Published: |
Codon Publications
2019
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| Online Access: | http://hdl.handle.net/20.500.11937/77927 |
| _version_ | 1848763921070030848 |
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| author | Bolik, Julia Tirnitz-Parker, Nina Schmidt-Arras, Dirk |
| author_facet | Bolik, Julia Tirnitz-Parker, Nina Schmidt-Arras, Dirk |
| author_sort | Bolik, Julia |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Proteolysis is an irreversible post-translational modification that regulates protein function and signal transduction. This includes remodelling of the extracellular matrix, release of membrane-bound cytokines and receptor ectodomains, as well as the
initiation of intracellular signalling cues. Members of the adamalysin protease subfamily, in particular the ADAM (a disintegrin
and metalloprotease) and ADAMTS (the ADAM containing thrombospondin motif) families, are involved in these processes.
This review presents an overview of how ADAM and ADAMTS proteins are involved in liver physiology and pathophysiology. |
| first_indexed | 2025-11-14T11:11:08Z |
| format | Journal Article |
| id | curtin-20.500.11937-77927 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:11:08Z |
| publishDate | 2019 |
| publisher | Codon Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-779272020-05-12T01:42:37Z ADAM and ADAMTS Proteases in Hepatic Disorders Bolik, Julia Tirnitz-Parker, Nina Schmidt-Arras, Dirk Proteolysis is an irreversible post-translational modification that regulates protein function and signal transduction. This includes remodelling of the extracellular matrix, release of membrane-bound cytokines and receptor ectodomains, as well as the initiation of intracellular signalling cues. Members of the adamalysin protease subfamily, in particular the ADAM (a disintegrin and metalloprotease) and ADAMTS (the ADAM containing thrombospondin motif) families, are involved in these processes. This review presents an overview of how ADAM and ADAMTS proteins are involved in liver physiology and pathophysiology. 2019 Journal Article http://hdl.handle.net/20.500.11937/77927 10.15586/jrenhep.2019.47 http://creativecommons.org/licenses/by/4.0 Codon Publications fulltext |
| spellingShingle | Bolik, Julia Tirnitz-Parker, Nina Schmidt-Arras, Dirk ADAM and ADAMTS Proteases in Hepatic Disorders |
| title | ADAM and ADAMTS Proteases in Hepatic Disorders |
| title_full | ADAM and ADAMTS Proteases in Hepatic Disorders |
| title_fullStr | ADAM and ADAMTS Proteases in Hepatic Disorders |
| title_full_unstemmed | ADAM and ADAMTS Proteases in Hepatic Disorders |
| title_short | ADAM and ADAMTS Proteases in Hepatic Disorders |
| title_sort | adam and adamts proteases in hepatic disorders |
| url | http://hdl.handle.net/20.500.11937/77927 |