Adaptive responses as mechanisms of resistance to braf inhibitors in melanoma

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Adaptive responses as mechanisms of resistance to braf inhibitors in melanoma

The introduction of v-raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors in melanoma patients with BRAF (V600E) mutations has demonstrated significant clinical benefits. However, rarely do tumours regress completely. Frequently, the reason for this is that therapies targeting specific onc...

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Bibliographic Details
Main Authors:	Saei, A., Eichhorn, Pieter
Format:	Journal Article
Language:	English
Published:	MDPI 2019
Subjects:	Science & Technology Life Sciences & Biomedicine Oncology BRAF melanoma adaptive responses resistance NEGATIVE-FEEDBACK-REGULATION ADVANCED SOLID TUMORS PHASE-I TRIAL KINASE PATHWAY ACQUIRED-RESISTANCE UP-REGULATION RAF KINASE AUTOPHAGY ERK MITF
Online Access:	http://hdl.handle.net/20.500.11937/77890

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