Adaptive responses as mechanisms of resistance to braf inhibitors in melanoma
The introduction of v-raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors in melanoma patients with BRAF (V600E) mutations has demonstrated significant clinical benefits. However, rarely do tumours regress completely. Frequently, the reason for this is that therapies targeting specific onc...
| Main Authors: | , |
|---|---|
| Format: | Journal Article |
| Language: | English |
| Published: |
MDPI
2019
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/77890 |
| _version_ | 1848763914013114368 |
|---|---|
| author | Saei, A. Eichhorn, Pieter |
| author_facet | Saei, A. Eichhorn, Pieter |
| author_sort | Saei, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The introduction of v-raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors in melanoma patients with BRAF (V600E) mutations has demonstrated significant clinical benefits. However, rarely do tumours regress completely. Frequently, the reason for this is that therapies targeting specific oncogenic mutations induce a number of intrinsic compensatory mechanisms, also known as adaptive responses or feedback loops, that enhance the pro-survival and pro-proliferative capacity of a proportion of the original tumour population, thereby resulting in tumour progression. In this review we will summarize the known adaptive responses that limit BRAF mutant therapy and discuss potential novel combinatorial therapies to overcome resistance. |
| first_indexed | 2025-11-14T11:11:01Z |
| format | Journal Article |
| id | curtin-20.500.11937-77890 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:11:01Z |
| publishDate | 2019 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-778902020-04-24T01:53:05Z Adaptive responses as mechanisms of resistance to braf inhibitors in melanoma Saei, A. Eichhorn, Pieter Science & Technology Life Sciences & Biomedicine Oncology BRAF melanoma adaptive responses resistance NEGATIVE-FEEDBACK-REGULATION ADVANCED SOLID TUMORS PHASE-I TRIAL KINASE PATHWAY ACQUIRED-RESISTANCE UP-REGULATION RAF KINASE AUTOPHAGY ERK MITF The introduction of v-raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors in melanoma patients with BRAF (V600E) mutations has demonstrated significant clinical benefits. However, rarely do tumours regress completely. Frequently, the reason for this is that therapies targeting specific oncogenic mutations induce a number of intrinsic compensatory mechanisms, also known as adaptive responses or feedback loops, that enhance the pro-survival and pro-proliferative capacity of a proportion of the original tumour population, thereby resulting in tumour progression. In this review we will summarize the known adaptive responses that limit BRAF mutant therapy and discuss potential novel combinatorial therapies to overcome resistance. 2019 Journal Article http://hdl.handle.net/20.500.11937/77890 10.3390/cancers11081176 English http://creativecommons.org/licenses/by/4.0/ MDPI fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Oncology BRAF melanoma adaptive responses resistance NEGATIVE-FEEDBACK-REGULATION ADVANCED SOLID TUMORS PHASE-I TRIAL KINASE PATHWAY ACQUIRED-RESISTANCE UP-REGULATION RAF KINASE AUTOPHAGY ERK MITF Saei, A. Eichhorn, Pieter Adaptive responses as mechanisms of resistance to braf inhibitors in melanoma |
| title | Adaptive responses as mechanisms of resistance to braf inhibitors in melanoma |
| title_full | Adaptive responses as mechanisms of resistance to braf inhibitors in melanoma |
| title_fullStr | Adaptive responses as mechanisms of resistance to braf inhibitors in melanoma |
| title_full_unstemmed | Adaptive responses as mechanisms of resistance to braf inhibitors in melanoma |
| title_short | Adaptive responses as mechanisms of resistance to braf inhibitors in melanoma |
| title_sort | adaptive responses as mechanisms of resistance to braf inhibitors in melanoma |
| topic | Science & Technology Life Sciences & Biomedicine Oncology BRAF melanoma adaptive responses resistance NEGATIVE-FEEDBACK-REGULATION ADVANCED SOLID TUMORS PHASE-I TRIAL KINASE PATHWAY ACQUIRED-RESISTANCE UP-REGULATION RAF KINASE AUTOPHAGY ERK MITF |
| url | http://hdl.handle.net/20.500.11937/77890 |