ABC transporters and G protein-coupled receptors: perspectives for novel anti-cancer drugs
Pancreatic Ductal Adenocarcinoma (PDAC) is a very aggressive disease with high mortality rates and lacking effective therapeutic approach. Therefore, it is pivotal to develop novel treatments to improve the grim prognosis of patients. In my PhD project, I demonstrated the existence of an ABCC3-LPI-G...
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| Format: | Thesis |
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Curtin University
2019
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| Online Access: | http://hdl.handle.net/20.500.11937/77548 |
| _version_ | 1848763862644424704 |
|---|---|
| author | Adamska, Aleksandra |
| author_facet | Adamska, Aleksandra |
| author_sort | Adamska, Aleksandra |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Pancreatic Ductal Adenocarcinoma (PDAC) is a very aggressive disease with high mortality rates and lacking effective therapeutic approach. Therefore, it is pivotal to develop novel treatments to improve the grim prognosis of patients. In my PhD project, I demonstrated the existence of an ABCC3-LPI-GPR55 loop in PDAC which activation boosts PDAC progression. Importantly, the pharmacological potential of this loop was demonstrated both in vitro and in vivo PDAC models paving a way to clinical trials. |
| first_indexed | 2025-11-14T11:10:12Z |
| format | Thesis |
| id | curtin-20.500.11937-77548 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:10:12Z |
| publishDate | 2019 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-775482022-01-04T01:27:03Z ABC transporters and G protein-coupled receptors: perspectives for novel anti-cancer drugs Adamska, Aleksandra Pancreatic Ductal Adenocarcinoma (PDAC) is a very aggressive disease with high mortality rates and lacking effective therapeutic approach. Therefore, it is pivotal to develop novel treatments to improve the grim prognosis of patients. In my PhD project, I demonstrated the existence of an ABCC3-LPI-GPR55 loop in PDAC which activation boosts PDAC progression. Importantly, the pharmacological potential of this loop was demonstrated both in vitro and in vivo PDAC models paving a way to clinical trials. 2019 Thesis http://hdl.handle.net/20.500.11937/77548 Curtin University fulltext |
| spellingShingle | Adamska, Aleksandra ABC transporters and G protein-coupled receptors: perspectives for novel anti-cancer drugs |
| title | ABC transporters and G protein-coupled receptors: perspectives for novel anti-cancer drugs |
| title_full | ABC transporters and G protein-coupled receptors: perspectives for novel anti-cancer drugs |
| title_fullStr | ABC transporters and G protein-coupled receptors: perspectives for novel anti-cancer drugs |
| title_full_unstemmed | ABC transporters and G protein-coupled receptors: perspectives for novel anti-cancer drugs |
| title_short | ABC transporters and G protein-coupled receptors: perspectives for novel anti-cancer drugs |
| title_sort | abc transporters and g protein-coupled receptors: perspectives for novel anti-cancer drugs |
| url | http://hdl.handle.net/20.500.11937/77548 |