Investigating the Relationship Between Statins and Bacterial Skin Infections
Statins are extensively prescribed medicines to reduce cholesterol for cardioprotection, but they also exhibit antimicrobial and pleiotropic effects, which plausibly reduces both skin infection risks and antimicrobial resistance. Adopting a bench-to-bedside framework, the results of laboratory exper...
| Main Author: | |
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| Format: | Thesis |
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Curtin University
2019
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| Online Access: | http://hdl.handle.net/20.500.11937/77546 |
| _version_ | 1848763862041493504 |
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| author | Ko, Hean Teik Humphrey |
| author_facet | Ko, Hean Teik Humphrey |
| author_sort | Ko, Hean Teik Humphrey |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Statins are extensively prescribed medicines to reduce cholesterol for cardioprotection, but they also exhibit antimicrobial and pleiotropic effects, which plausibly reduces both skin infection risks and antimicrobial resistance. Adopting a bench-to-bedside framework, the results of laboratory experiments (identifying suitable statins as topical antibiotics and postulating a mechanism of antibacterial action) and clinical evidence (via prescription sequence symmetry analysis and a retrospective case-control study) were reconciled to determine if prior statin use translated into beneficial outcomes. |
| first_indexed | 2025-11-14T11:10:12Z |
| format | Thesis |
| id | curtin-20.500.11937-77546 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:10:12Z |
| publishDate | 2019 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-775462022-01-04T01:25:49Z Investigating the Relationship Between Statins and Bacterial Skin Infections Ko, Hean Teik Humphrey Statins are extensively prescribed medicines to reduce cholesterol for cardioprotection, but they also exhibit antimicrobial and pleiotropic effects, which plausibly reduces both skin infection risks and antimicrobial resistance. Adopting a bench-to-bedside framework, the results of laboratory experiments (identifying suitable statins as topical antibiotics and postulating a mechanism of antibacterial action) and clinical evidence (via prescription sequence symmetry analysis and a retrospective case-control study) were reconciled to determine if prior statin use translated into beneficial outcomes. 2019 Thesis http://hdl.handle.net/20.500.11937/77546 Curtin University fulltext |
| spellingShingle | Ko, Hean Teik Humphrey Investigating the Relationship Between Statins and Bacterial Skin Infections |
| title | Investigating the Relationship Between Statins and Bacterial Skin Infections |
| title_full | Investigating the Relationship Between Statins and Bacterial Skin Infections |
| title_fullStr | Investigating the Relationship Between Statins and Bacterial Skin Infections |
| title_full_unstemmed | Investigating the Relationship Between Statins and Bacterial Skin Infections |
| title_short | Investigating the Relationship Between Statins and Bacterial Skin Infections |
| title_sort | investigating the relationship between statins and bacterial skin infections |
| url | http://hdl.handle.net/20.500.11937/77546 |