The role of genetic diversity in the replication, pathogenicity and virulence of Murray Valley encephalitis virus
Genetic and phenotypic variation of genotype 1 (G1) and genotype 2 (G2) Murray valley encephalitis virus (MVEV) were characterised. G2 viruses were a minority, had lower levels of genetic diversity and an attenuated phenotype in the mouse model of MVE. G1 isolates were abundant with higher levels of...
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| Format: | Thesis |
| Language: | English |
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Curtin University
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/774 |
| _version_ | 1848743476541259776 |
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| author | Niazi, Aziz-ur-Rahman |
| author_facet | Niazi, Aziz-ur-Rahman |
| author_sort | Niazi, Aziz-ur-Rahman |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Genetic and phenotypic variation of genotype 1 (G1) and genotype 2 (G2) Murray valley encephalitis virus (MVEV) were characterised. G2 viruses were a minority, had lower levels of genetic diversity and an attenuated phenotype in the mouse model of MVE. G1 isolates were abundant with higher levels of genetic diversity and a virulent phenotype. The restricted evolution of MVEV was due to multiplication in mosquito cells. An RT-qPCR assay detecting all MVEV genotypes was developed. |
| first_indexed | 2025-11-14T05:46:11Z |
| format | Thesis |
| id | curtin-20.500.11937-774 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T05:46:11Z |
| publishDate | 2013 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-7742017-02-20T06:41:06Z The role of genetic diversity in the replication, pathogenicity and virulence of Murray Valley encephalitis virus Niazi, Aziz-ur-Rahman Genetic and phenotypic variation of genotype 1 (G1) and genotype 2 (G2) Murray valley encephalitis virus (MVEV) were characterised. G2 viruses were a minority, had lower levels of genetic diversity and an attenuated phenotype in the mouse model of MVE. G1 isolates were abundant with higher levels of genetic diversity and a virulent phenotype. The restricted evolution of MVEV was due to multiplication in mosquito cells. An RT-qPCR assay detecting all MVEV genotypes was developed. 2013 Thesis http://hdl.handle.net/20.500.11937/774 en Curtin University fulltext |
| spellingShingle | Niazi, Aziz-ur-Rahman The role of genetic diversity in the replication, pathogenicity and virulence of Murray Valley encephalitis virus |
| title | The role of genetic diversity in the replication, pathogenicity and virulence of Murray Valley encephalitis virus |
| title_full | The role of genetic diversity in the replication, pathogenicity and virulence of Murray Valley encephalitis virus |
| title_fullStr | The role of genetic diversity in the replication, pathogenicity and virulence of Murray Valley encephalitis virus |
| title_full_unstemmed | The role of genetic diversity in the replication, pathogenicity and virulence of Murray Valley encephalitis virus |
| title_short | The role of genetic diversity in the replication, pathogenicity and virulence of Murray Valley encephalitis virus |
| title_sort | role of genetic diversity in the replication, pathogenicity and virulence of murray valley encephalitis virus |
| url | http://hdl.handle.net/20.500.11937/774 |