Platelet-cancer Crosstalk: Mechanisms and Therapeutic Implications
Platelets are small anucleate blood cells that are central to primary haemostasis. However, platelets are also implicated in cancer pathogenesis. This thesis showed that cancer cells promote thrombosis by activating platelets, and in turn, platelets provide cancer cells with growth factors to render...
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| Format: | Thesis |
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Curtin University
2019
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| Online Access: | http://hdl.handle.net/20.500.11937/77186 |
| _version_ | 1848763822024687616 |
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| author | Elaskalani, Omar |
| author_facet | Elaskalani, Omar |
| author_sort | Elaskalani, Omar |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Platelets are small anucleate blood cells that are central to primary haemostasis. However, platelets are also implicated in cancer pathogenesis. This thesis showed that cancer cells promote thrombosis by activating platelets, and in turn, platelets provide cancer cells with growth factors to render cancer more aggressive and chemoresistant. The thesis demonstrated a therapeutic benefit of combined antiplatelet, ticagrelor, and chemo drugs, on cancer treatment. |
| first_indexed | 2025-11-14T11:09:34Z |
| format | Thesis |
| id | curtin-20.500.11937-77186 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:09:34Z |
| publishDate | 2019 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-771862019-12-06T00:38:43Z Platelet-cancer Crosstalk: Mechanisms and Therapeutic Implications Elaskalani, Omar Platelets are small anucleate blood cells that are central to primary haemostasis. However, platelets are also implicated in cancer pathogenesis. This thesis showed that cancer cells promote thrombosis by activating platelets, and in turn, platelets provide cancer cells with growth factors to render cancer more aggressive and chemoresistant. The thesis demonstrated a therapeutic benefit of combined antiplatelet, ticagrelor, and chemo drugs, on cancer treatment. 2019 Thesis http://hdl.handle.net/20.500.11937/77186 Curtin University fulltext |
| spellingShingle | Elaskalani, Omar Platelet-cancer Crosstalk: Mechanisms and Therapeutic Implications |
| title | Platelet-cancer Crosstalk: Mechanisms and Therapeutic Implications |
| title_full | Platelet-cancer Crosstalk: Mechanisms and Therapeutic Implications |
| title_fullStr | Platelet-cancer Crosstalk: Mechanisms and Therapeutic Implications |
| title_full_unstemmed | Platelet-cancer Crosstalk: Mechanisms and Therapeutic Implications |
| title_short | Platelet-cancer Crosstalk: Mechanisms and Therapeutic Implications |
| title_sort | platelet-cancer crosstalk: mechanisms and therapeutic implications |
| url | http://hdl.handle.net/20.500.11937/77186 |