A Novel Radiofluorination Method for the Design of Rhenium(I) PET-Optical Hybrid Nuclear Medicines
Novel fluorine-18 labelled luminescent rhenium tricarbonyl complexes were synthesised to test their utility as agents for position emission tomography (PET) and optical hybrid imaging. These experiments lead to the discovery of a rhenium complexation-dissociation method, which produced never-before-...
| Main Author: | |
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| Format: | Thesis |
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Curtin University
2019
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| Online Access: | http://hdl.handle.net/20.500.11937/77107 |
| _version_ | 1848763816968454144 |
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| author | Klenner, Mitchell Ashley |
| author_facet | Klenner, Mitchell Ashley |
| author_sort | Klenner, Mitchell Ashley |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Novel fluorine-18 labelled luminescent rhenium tricarbonyl complexes were synthesised to test their utility as agents for position emission tomography (PET) and optical hybrid imaging. These experiments lead to the discovery of a rhenium complexation-dissociation method, which produced never-before-seen radiotracers in substantial radiochemical yields that were unable to be radiosynthesised by traditional means. This method was further applied to the successful production of the Alzheimer’s disease PET imaging nuclear medicine, [18F]CABS13, and new analogues thereof. |
| first_indexed | 2025-11-14T11:09:29Z |
| format | Thesis |
| id | curtin-20.500.11937-77107 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:09:29Z |
| publishDate | 2019 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-771072019-12-05T05:28:26Z A Novel Radiofluorination Method for the Design of Rhenium(I) PET-Optical Hybrid Nuclear Medicines Klenner, Mitchell Ashley Novel fluorine-18 labelled luminescent rhenium tricarbonyl complexes were synthesised to test their utility as agents for position emission tomography (PET) and optical hybrid imaging. These experiments lead to the discovery of a rhenium complexation-dissociation method, which produced never-before-seen radiotracers in substantial radiochemical yields that were unable to be radiosynthesised by traditional means. This method was further applied to the successful production of the Alzheimer’s disease PET imaging nuclear medicine, [18F]CABS13, and new analogues thereof. 2019 Thesis http://hdl.handle.net/20.500.11937/77107 Curtin University fulltext |
| spellingShingle | Klenner, Mitchell Ashley A Novel Radiofluorination Method for the Design of Rhenium(I) PET-Optical Hybrid Nuclear Medicines |
| title | A Novel Radiofluorination Method for the Design of Rhenium(I) PET-Optical Hybrid Nuclear Medicines |
| title_full | A Novel Radiofluorination Method for the Design of Rhenium(I) PET-Optical Hybrid Nuclear Medicines |
| title_fullStr | A Novel Radiofluorination Method for the Design of Rhenium(I) PET-Optical Hybrid Nuclear Medicines |
| title_full_unstemmed | A Novel Radiofluorination Method for the Design of Rhenium(I) PET-Optical Hybrid Nuclear Medicines |
| title_short | A Novel Radiofluorination Method for the Design of Rhenium(I) PET-Optical Hybrid Nuclear Medicines |
| title_sort | novel radiofluorination method for the design of rhenium(i) pet-optical hybrid nuclear medicines |
| url | http://hdl.handle.net/20.500.11937/77107 |