Limbal stem cells: The search for a marker
The corneal epithelium is a self-renewing tissue and must, by definition, have a resident basal cell population necessary for homeostasis and wound healing. There is a substantial body of evidence, both experimental and clinical, pointing to the basal cells of the limbus as the location of corneal e...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2006
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/76829 |
| _version_ | 1848763771079622656 |
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| author | Chee, K.Y.H. Kicic, Anthony Wiffen, S.J. |
| author_facet | Chee, K.Y.H. Kicic, Anthony Wiffen, S.J. |
| author_sort | Chee, K.Y.H. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The corneal epithelium is a self-renewing tissue and must, by definition, have a resident basal cell population necessary for homeostasis and wound healing. There is a substantial body of evidence, both experimental and clinical, pointing to the basal cells of the limbus as the location of corneal epithelial stem cells. However, in the absence of a definitive marker of limbal stem cells, the evidence remains largely circumstantial. Many markers such as p63 and integrin α9 are preferentially localized to the limbus but cannot be regarded as stem cell-specific. Other markers such as K3 and connexin 43 can be regarded as markers of corneal differentiation. The discovery of stem cell markers in other organ systems, such as the haematopoietic system, offers optimism that a marker of limbal stem cells will one day be found. Such a discovery will have far-reaching implications for the study of ocular surface biology and stratified squamous epithelia in general. © 2006 Royal Australian and New Zealand College of Ophthalmologists. |
| first_indexed | 2025-11-14T11:08:45Z |
| format | Journal Article |
| id | curtin-20.500.11937-76829 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:08:45Z |
| publishDate | 2006 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-768292019-11-12T08:23:52Z Limbal stem cells: The search for a marker Chee, K.Y.H. Kicic, Anthony Wiffen, S.J. Biomarkers Epithelial Cells Epithelium, Corneal Humans Limbus Corneae Stem Cell Transplantation Stem Cells The corneal epithelium is a self-renewing tissue and must, by definition, have a resident basal cell population necessary for homeostasis and wound healing. There is a substantial body of evidence, both experimental and clinical, pointing to the basal cells of the limbus as the location of corneal epithelial stem cells. However, in the absence of a definitive marker of limbal stem cells, the evidence remains largely circumstantial. Many markers such as p63 and integrin α9 are preferentially localized to the limbus but cannot be regarded as stem cell-specific. Other markers such as K3 and connexin 43 can be regarded as markers of corneal differentiation. The discovery of stem cell markers in other organ systems, such as the haematopoietic system, offers optimism that a marker of limbal stem cells will one day be found. Such a discovery will have far-reaching implications for the study of ocular surface biology and stratified squamous epithelia in general. © 2006 Royal Australian and New Zealand College of Ophthalmologists. 2006 Journal Article http://hdl.handle.net/20.500.11937/76829 10.1111/j.1442-9071.2006.01147.x eng restricted |
| spellingShingle | Biomarkers Epithelial Cells Epithelium, Corneal Humans Limbus Corneae Stem Cell Transplantation Stem Cells Chee, K.Y.H. Kicic, Anthony Wiffen, S.J. Limbal stem cells: The search for a marker |
| title | Limbal stem cells: The search for a marker |
| title_full | Limbal stem cells: The search for a marker |
| title_fullStr | Limbal stem cells: The search for a marker |
| title_full_unstemmed | Limbal stem cells: The search for a marker |
| title_short | Limbal stem cells: The search for a marker |
| title_sort | limbal stem cells: the search for a marker |
| topic | Biomarkers Epithelial Cells Epithelium, Corneal Humans Limbus Corneae Stem Cell Transplantation Stem Cells |
| url | http://hdl.handle.net/20.500.11937/76829 |