Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis
© 2018 European Cystic Fibrosis Society Background: Little is known about the role of interleukin (IL)-1 in the pathogenesis of cystic fibrosis (CF) lung disease. This study investigated the relationship between IL-1 signalling, neutrophilic inflammation and structural lung changes in children with...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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ELSEVIER SCIENCE BV
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/76797 |
| _version_ | 1848763761979031552 |
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| author | Montgomery, S.T. Dittrich, A.S. Garratt, L.W. Turkovic, L. Frey, D.L. Stick, S.M. Mall, M.A. Kicic, Anthony |
| author_facet | Montgomery, S.T. Dittrich, A.S. Garratt, L.W. Turkovic, L. Frey, D.L. Stick, S.M. Mall, M.A. Kicic, Anthony |
| author_sort | Montgomery, S.T. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 European Cystic Fibrosis Society Background: Little is known about the role of interleukin (IL)-1 in the pathogenesis of cystic fibrosis (CF) lung disease. This study investigated the relationship between IL-1 signalling, neutrophilic inflammation and structural lung changes in children with CF. Methods: Bronchoalveolar lavage fluid (BALf) from 102 children with CF were used to determine IL-1α, IL-1β, IL-8 levels and neutrophil elastase (NE) activity, which were then correlated to structural lung changes observed on chest computed tomography (CT) scans. Results: IL-1α and IL-1β were detectable in BAL in absence of infection, increased in the presence of bacterial infection and correlated with IL-8 (p < 0.0001), neutrophils (p < 0.0001) and NE activity (p < 0.01 and p < 0.001). IL-1α had the strongest association with structural lung disease (p < 0.01) in the absence of infection (uninfected: p < 0.01 vs. infected: p = 0.122). Conclusion: Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target. |
| first_indexed | 2025-11-14T11:08:36Z |
| format | Journal Article |
| id | curtin-20.500.11937-76797 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:08:36Z |
| publishDate | 2018 |
| publisher | ELSEVIER SCIENCE BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-767972019-11-11T06:44:18Z Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis Montgomery, S.T. Dittrich, A.S. Garratt, L.W. Turkovic, L. Frey, D.L. Stick, S.M. Mall, M.A. Kicic, Anthony Science & Technology Life Sciences & Biomedicine Respiratory System Airway epithelium Hypoxia Neutrophilic inflammation Cystic fibrosis Interleukin (IL)-1 Mucus MUCUS BRONCHIECTASIS ACTIVATION CLEARANCE SECRETION EMPHYSEMA THERAPY INFANTS CF © 2018 European Cystic Fibrosis Society Background: Little is known about the role of interleukin (IL)-1 in the pathogenesis of cystic fibrosis (CF) lung disease. This study investigated the relationship between IL-1 signalling, neutrophilic inflammation and structural lung changes in children with CF. Methods: Bronchoalveolar lavage fluid (BALf) from 102 children with CF were used to determine IL-1α, IL-1β, IL-8 levels and neutrophil elastase (NE) activity, which were then correlated to structural lung changes observed on chest computed tomography (CT) scans. Results: IL-1α and IL-1β were detectable in BAL in absence of infection, increased in the presence of bacterial infection and correlated with IL-8 (p < 0.0001), neutrophils (p < 0.0001) and NE activity (p < 0.01 and p < 0.001). IL-1α had the strongest association with structural lung disease (p < 0.01) in the absence of infection (uninfected: p < 0.01 vs. infected: p = 0.122). Conclusion: Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target. 2018 Journal Article http://hdl.handle.net/20.500.11937/76797 10.1016/j.jcf.2018.05.006 English ELSEVIER SCIENCE BV restricted |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Respiratory System Airway epithelium Hypoxia Neutrophilic inflammation Cystic fibrosis Interleukin (IL)-1 Mucus MUCUS BRONCHIECTASIS ACTIVATION CLEARANCE SECRETION EMPHYSEMA THERAPY INFANTS CF Montgomery, S.T. Dittrich, A.S. Garratt, L.W. Turkovic, L. Frey, D.L. Stick, S.M. Mall, M.A. Kicic, Anthony Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis |
| title | Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis |
| title_full | Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis |
| title_fullStr | Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis |
| title_full_unstemmed | Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis |
| title_short | Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis |
| title_sort | interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis |
| topic | Science & Technology Life Sciences & Biomedicine Respiratory System Airway epithelium Hypoxia Neutrophilic inflammation Cystic fibrosis Interleukin (IL)-1 Mucus MUCUS BRONCHIECTASIS ACTIVATION CLEARANCE SECRETION EMPHYSEMA THERAPY INFANTS CF |
| url | http://hdl.handle.net/20.500.11937/76797 |