Preterm birth: Born too soon for the developing airway epithelium?
© 2018 Elsevier Ltd. Birth prior to term interrupts the normal development of the respiratory system and consequently results in poor respiratory outcomes that persist throughout childhood. The mechanisms underpinning these poor respiratory outcomes are not well understood, but intrinsic abnormaliti...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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ELSEVIER SCI LTD
2019
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/76778 |
| _version_ | 1848763756906020864 |
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| author | Looi, K. Evans, D.J. Garratt, L.W. Ang, S. Hillas, J.K. Kicic, Anthony Simpson, S.J. |
| author_facet | Looi, K. Evans, D.J. Garratt, L.W. Ang, S. Hillas, J.K. Kicic, Anthony Simpson, S.J. |
| author_sort | Looi, K. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 Elsevier Ltd. Birth prior to term interrupts the normal development of the respiratory system and consequently results in poor respiratory outcomes that persist throughout childhood. The mechanisms underpinning these poor respiratory outcomes are not well understood, but intrinsic abnormalities within the airway epithelium may be a contributing factor. Current evidence suggests that the airway epithelium is both structurally and functionally abnormal after preterm birth, with reports of epithelial thickening and goblet cell hyperplasia in addition to increased inflammation and apoptosis in the neonatal intensive care unit. However, studies focusing on the airway epithelium are limited and many questions remain unanswered; including whether abnormalities are a direct result of interrupted development, a consequence of exposure to inflammatory stimuli in the perinatal period or a combination of the two. In addition, the difficulty of accessing airway tissue has resulted in the majority of evidence being collected in the pre-surfactant era which may not reflect contemporary preterm birth. This review examines the consequences of preterm birth on the airway epithelium and explores the clinical relevance of currently available models whilst highlighting the need to develop a clinically relevant in vitro model to help further our understanding of the airway epithelium in preterm birth. |
| first_indexed | 2025-11-14T11:08:32Z |
| format | Journal Article |
| id | curtin-20.500.11937-76778 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:08:32Z |
| publishDate | 2019 |
| publisher | ELSEVIER SCI LTD |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-767782019-11-11T06:38:30Z Preterm birth: Born too soon for the developing airway epithelium? Looi, K. Evans, D.J. Garratt, L.W. Ang, S. Hillas, J.K. Kicic, Anthony Simpson, S.J. Science & Technology Life Sciences & Biomedicine Pediatrics Respiratory System Airway epithelial cell Bronchopulmonary dysplasia Chronic lung disease Respiratory In-vitro model SURFACTANT REPLACEMENT THERAPY BRONCHOALVEOLAR LAVAGE FLUID HYALINE-MEMBRANE DISEASE GOBLET CELL HYPERPLASIA CHRONIC LUNG-DISEASE PREMATURE-INFANTS BRONCHOPULMONARY DYSPLASIA ANIMAL-MODELS INTERLEUKIN (IL)-1-BETA RESPIRATORY SYMPTOMS © 2018 Elsevier Ltd. Birth prior to term interrupts the normal development of the respiratory system and consequently results in poor respiratory outcomes that persist throughout childhood. The mechanisms underpinning these poor respiratory outcomes are not well understood, but intrinsic abnormalities within the airway epithelium may be a contributing factor. Current evidence suggests that the airway epithelium is both structurally and functionally abnormal after preterm birth, with reports of epithelial thickening and goblet cell hyperplasia in addition to increased inflammation and apoptosis in the neonatal intensive care unit. However, studies focusing on the airway epithelium are limited and many questions remain unanswered; including whether abnormalities are a direct result of interrupted development, a consequence of exposure to inflammatory stimuli in the perinatal period or a combination of the two. In addition, the difficulty of accessing airway tissue has resulted in the majority of evidence being collected in the pre-surfactant era which may not reflect contemporary preterm birth. This review examines the consequences of preterm birth on the airway epithelium and explores the clinical relevance of currently available models whilst highlighting the need to develop a clinically relevant in vitro model to help further our understanding of the airway epithelium in preterm birth. 2019 Journal Article http://hdl.handle.net/20.500.11937/76778 10.1016/j.prrv.2018.11.003 English ELSEVIER SCI LTD restricted |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Pediatrics Respiratory System Airway epithelial cell Bronchopulmonary dysplasia Chronic lung disease Respiratory In-vitro model SURFACTANT REPLACEMENT THERAPY BRONCHOALVEOLAR LAVAGE FLUID HYALINE-MEMBRANE DISEASE GOBLET CELL HYPERPLASIA CHRONIC LUNG-DISEASE PREMATURE-INFANTS BRONCHOPULMONARY DYSPLASIA ANIMAL-MODELS INTERLEUKIN (IL)-1-BETA RESPIRATORY SYMPTOMS Looi, K. Evans, D.J. Garratt, L.W. Ang, S. Hillas, J.K. Kicic, Anthony Simpson, S.J. Preterm birth: Born too soon for the developing airway epithelium? |
| title | Preterm birth: Born too soon for the developing airway epithelium? |
| title_full | Preterm birth: Born too soon for the developing airway epithelium? |
| title_fullStr | Preterm birth: Born too soon for the developing airway epithelium? |
| title_full_unstemmed | Preterm birth: Born too soon for the developing airway epithelium? |
| title_short | Preterm birth: Born too soon for the developing airway epithelium? |
| title_sort | preterm birth: born too soon for the developing airway epithelium? |
| topic | Science & Technology Life Sciences & Biomedicine Pediatrics Respiratory System Airway epithelial cell Bronchopulmonary dysplasia Chronic lung disease Respiratory In-vitro model SURFACTANT REPLACEMENT THERAPY BRONCHOALVEOLAR LAVAGE FLUID HYALINE-MEMBRANE DISEASE GOBLET CELL HYPERPLASIA CHRONIC LUNG-DISEASE PREMATURE-INFANTS BRONCHOPULMONARY DYSPLASIA ANIMAL-MODELS INTERLEUKIN (IL)-1-BETA RESPIRATORY SYMPTOMS |
| url | http://hdl.handle.net/20.500.11937/76778 |