Elucidating the interaction of CF airway epithelial cells and rhinovirus: Using the host-pathogen relationship to identify future therapeutic strategies
© 2018 Ling, Garratt, Lassmann, Stick. Chronic lung disease remains the primary cause of mortality in cystic fibrosis (CF). Growing evidence suggests respiratory viral infections are often more severe in CF compared to healthy peers and contributes to pulmonary exacerbations (PEx) and deterioration...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | English |
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FRONTIERS MEDIA SA
2018
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/76774 |
| _version_ | 1848763755596349440 |
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| author | Ling, K.M. Garratt, L.W. Lassmann, T. Stick, S.M. Kicic, Anthony |
| author_facet | Ling, K.M. Garratt, L.W. Lassmann, T. Stick, S.M. Kicic, Anthony |
| author_sort | Ling, K.M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 Ling, Garratt, Lassmann, Stick. Chronic lung disease remains the primary cause of mortality in cystic fibrosis (CF). Growing evidence suggests respiratory viral infections are often more severe in CF compared to healthy peers and contributes to pulmonary exacerbations (PEx) and deterioration of lung function. Rhinovirus is the most prevalent respiratory virus detected, particularly during exacerbations in children with CF < 5 years old. However, even though rhinoviral infections are likely to be one of the factors initiating the onset of CF lung disease, there is no effective targeted treatment. A better understanding of the innate immune responses by CF airway epithelial cells, the primary site of infection for viruses, is needed to identify why viral infections are more severe in CF. The aim of this review is to present the clinical impact of virus infection in both young children and adults with CF, focusing on rhinovirus infection. Previous in vitro and in vivo investigations looking at the mechanisms behind virus infection will also be summarized. The review will finish on the potential of transcriptomics to elucidate the host-pathogen responses by CF airway cells to viral infection and identify novel therapeutic targets. |
| first_indexed | 2025-11-14T11:08:30Z |
| format | Journal Article |
| id | curtin-20.500.11937-76774 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:08:30Z |
| publishDate | 2018 |
| publisher | FRONTIERS MEDIA SA |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-767742019-11-11T03:27:03Z Elucidating the interaction of CF airway epithelial cells and rhinovirus: Using the host-pathogen relationship to identify future therapeutic strategies Ling, K.M. Garratt, L.W. Lassmann, T. Stick, S.M. Kicic, Anthony Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy cystic fibrosis airway epithelium rhinovirus innate immune response therapy transcriptomic CYSTIC-FIBROSIS RESPIRATORY VIRUSES PULMONARY EXACERBATIONS VIRAL-INFECTIONS YOUNG-CHILDREN INFANTS ASTHMA INTERFERON RESPONSES SYMPTOMS © 2018 Ling, Garratt, Lassmann, Stick. Chronic lung disease remains the primary cause of mortality in cystic fibrosis (CF). Growing evidence suggests respiratory viral infections are often more severe in CF compared to healthy peers and contributes to pulmonary exacerbations (PEx) and deterioration of lung function. Rhinovirus is the most prevalent respiratory virus detected, particularly during exacerbations in children with CF < 5 years old. However, even though rhinoviral infections are likely to be one of the factors initiating the onset of CF lung disease, there is no effective targeted treatment. A better understanding of the innate immune responses by CF airway epithelial cells, the primary site of infection for viruses, is needed to identify why viral infections are more severe in CF. The aim of this review is to present the clinical impact of virus infection in both young children and adults with CF, focusing on rhinovirus infection. Previous in vitro and in vivo investigations looking at the mechanisms behind virus infection will also be summarized. The review will finish on the potential of transcriptomics to elucidate the host-pathogen responses by CF airway cells to viral infection and identify novel therapeutic targets. 2018 Journal Article http://hdl.handle.net/20.500.11937/76774 10.3389/fphar.2018.01270 English http://creativecommons.org/licenses/by/4.0/ FRONTIERS MEDIA SA fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy cystic fibrosis airway epithelium rhinovirus innate immune response therapy transcriptomic CYSTIC-FIBROSIS RESPIRATORY VIRUSES PULMONARY EXACERBATIONS VIRAL-INFECTIONS YOUNG-CHILDREN INFANTS ASTHMA INTERFERON RESPONSES SYMPTOMS Ling, K.M. Garratt, L.W. Lassmann, T. Stick, S.M. Kicic, Anthony Elucidating the interaction of CF airway epithelial cells and rhinovirus: Using the host-pathogen relationship to identify future therapeutic strategies |
| title | Elucidating the interaction of CF airway epithelial cells and rhinovirus: Using the host-pathogen relationship to identify future therapeutic strategies |
| title_full | Elucidating the interaction of CF airway epithelial cells and rhinovirus: Using the host-pathogen relationship to identify future therapeutic strategies |
| title_fullStr | Elucidating the interaction of CF airway epithelial cells and rhinovirus: Using the host-pathogen relationship to identify future therapeutic strategies |
| title_full_unstemmed | Elucidating the interaction of CF airway epithelial cells and rhinovirus: Using the host-pathogen relationship to identify future therapeutic strategies |
| title_short | Elucidating the interaction of CF airway epithelial cells and rhinovirus: Using the host-pathogen relationship to identify future therapeutic strategies |
| title_sort | elucidating the interaction of cf airway epithelial cells and rhinovirus: using the host-pathogen relationship to identify future therapeutic strategies |
| topic | Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy cystic fibrosis airway epithelium rhinovirus innate immune response therapy transcriptomic CYSTIC-FIBROSIS RESPIRATORY VIRUSES PULMONARY EXACERBATIONS VIRAL-INFECTIONS YOUNG-CHILDREN INFANTS ASTHMA INTERFERON RESPONSES SYMPTOMS |
| url | http://hdl.handle.net/20.500.11937/76774 |