The contribution of geogenic particulate matter to lung disease in indigenous children
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Indigenous children have much higher rates of ear and lung disease than non-Indigenous children, which may be related to exposure to high levels of geogenic (earth-derived) particulate matter (PM). The aim of this study was to assess the rela...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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MDPI
2019
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/76771 |
| _version_ | 1848763754815160320 |
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| author | Shepherd, C.C.J. Clifford, H.D. Mitrou, F. Melody, S.M. Bennett, E.J. Johnston, F.H. Knibbs, L.D. Pereira, Gavin Pickering, J.L. Teo, T.H. Kirkham, L.A.S. Thornton, R.B. Kicic, Anthony Ling, K.M. Alach, Z. Lester, M. Franklin, P. Reid, D. Zosky, G.R. |
| author_facet | Shepherd, C.C.J. Clifford, H.D. Mitrou, F. Melody, S.M. Bennett, E.J. Johnston, F.H. Knibbs, L.D. Pereira, Gavin Pickering, J.L. Teo, T.H. Kirkham, L.A.S. Thornton, R.B. Kicic, Anthony Ling, K.M. Alach, Z. Lester, M. Franklin, P. Reid, D. Zosky, G.R. |
| author_sort | Shepherd, C.C.J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Indigenous children have much higher rates of ear and lung disease than non-Indigenous children, which may be related to exposure to high levels of geogenic (earth-derived) particulate matter (PM). The aim of this study was to assess the relationship between dust levels and health in Indigenous children in Western Australia (W.A.). Data were from a population-based sample of 1077 Indigenous children living in 66 remote communities of W.A. (>2,000,000 km2), with information on health outcomes derived from carer reports and hospitalisation records. Associations between dust levels and health outcomes were assessed by multivariate logistic regression in a multi-level framework. We assessed the effect of exposure to community sampled PM on epithelial cell (NuLi-1) responses to non-typeable Haemophilus influenzae (NTHi) in vitro. High dust levels were associated with increased odds of hospitalisation for upper (OR 1.77 95% CI [1.02–3.06]) and lower (OR 1.99 95% CI [1.08–3.68]) respiratory tract infections and ear disease (OR 3.06 95% CI [1.20–7.80]). Exposure to PM enhanced NTHi adhesion and invasion of epithelial cells and impaired IL-8 production. Exposure to geogenic PM may be contributing to the poor respiratory health of disadvantaged communities in arid environments where geogenic PM levels are high. |
| first_indexed | 2025-11-14T11:08:30Z |
| format | Journal Article |
| id | curtin-20.500.11937-76771 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:08:30Z |
| publishDate | 2019 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-767712019-11-11T03:19:03Z The contribution of geogenic particulate matter to lung disease in indigenous children Shepherd, C.C.J. Clifford, H.D. Mitrou, F. Melody, S.M. Bennett, E.J. Johnston, F.H. Knibbs, L.D. Pereira, Gavin Pickering, J.L. Teo, T.H. Kirkham, L.A.S. Thornton, R.B. Kicic, Anthony Ling, K.M. Alach, Z. Lester, M. Franklin, P. Reid, D. Zosky, G.R. Science & Technology Life Sciences & Biomedicine Environmental Sciences Public, Environmental & Occupational Health Environmental Sciences & Ecology Indigenous child health geogenic particulate matter bacterial infection ENVIRONMENTAL-HEALTH NORTHERN-TERRITORY PARTICLES RESPONSES © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Indigenous children have much higher rates of ear and lung disease than non-Indigenous children, which may be related to exposure to high levels of geogenic (earth-derived) particulate matter (PM). The aim of this study was to assess the relationship between dust levels and health in Indigenous children in Western Australia (W.A.). Data were from a population-based sample of 1077 Indigenous children living in 66 remote communities of W.A. (>2,000,000 km2), with information on health outcomes derived from carer reports and hospitalisation records. Associations between dust levels and health outcomes were assessed by multivariate logistic regression in a multi-level framework. We assessed the effect of exposure to community sampled PM on epithelial cell (NuLi-1) responses to non-typeable Haemophilus influenzae (NTHi) in vitro. High dust levels were associated with increased odds of hospitalisation for upper (OR 1.77 95% CI [1.02–3.06]) and lower (OR 1.99 95% CI [1.08–3.68]) respiratory tract infections and ear disease (OR 3.06 95% CI [1.20–7.80]). Exposure to PM enhanced NTHi adhesion and invasion of epithelial cells and impaired IL-8 production. Exposure to geogenic PM may be contributing to the poor respiratory health of disadvantaged communities in arid environments where geogenic PM levels are high. 2019 Journal Article http://hdl.handle.net/20.500.11937/76771 10.3390/ijerph16152636 English http://creativecommons.org/licenses/by/4.0/ MDPI fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Environmental Sciences Public, Environmental & Occupational Health Environmental Sciences & Ecology Indigenous child health geogenic particulate matter bacterial infection ENVIRONMENTAL-HEALTH NORTHERN-TERRITORY PARTICLES RESPONSES Shepherd, C.C.J. Clifford, H.D. Mitrou, F. Melody, S.M. Bennett, E.J. Johnston, F.H. Knibbs, L.D. Pereira, Gavin Pickering, J.L. Teo, T.H. Kirkham, L.A.S. Thornton, R.B. Kicic, Anthony Ling, K.M. Alach, Z. Lester, M. Franklin, P. Reid, D. Zosky, G.R. The contribution of geogenic particulate matter to lung disease in indigenous children |
| title | The contribution of geogenic particulate matter to lung disease in indigenous children |
| title_full | The contribution of geogenic particulate matter to lung disease in indigenous children |
| title_fullStr | The contribution of geogenic particulate matter to lung disease in indigenous children |
| title_full_unstemmed | The contribution of geogenic particulate matter to lung disease in indigenous children |
| title_short | The contribution of geogenic particulate matter to lung disease in indigenous children |
| title_sort | contribution of geogenic particulate matter to lung disease in indigenous children |
| topic | Science & Technology Life Sciences & Biomedicine Environmental Sciences Public, Environmental & Occupational Health Environmental Sciences & Ecology Indigenous child health geogenic particulate matter bacterial infection ENVIRONMENTAL-HEALTH NORTHERN-TERRITORY PARTICLES RESPONSES |
| url | http://hdl.handle.net/20.500.11937/76771 |