New Routes to Troponoid Natural Products
Tropolones have antimalarial activity with a structure unique compared to current treatments. This study focuses on the development of new methods to prepare tropolones and devise a total synthesis of cordytropolone. A new synthesis of tropolones has been developed using thiophene-1,1-dioxides which...
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| Format: | Thesis |
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Curtin University
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/76286 |
| _version_ | 1848763650192441344 |
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| author | Wells, Jason Matthew |
| author_facet | Wells, Jason Matthew |
| author_sort | Wells, Jason Matthew |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Tropolones have antimalarial activity with a structure unique compared to current treatments. This study focuses on the development of new methods to prepare tropolones and devise a total synthesis of cordytropolone. A new synthesis of tropolones has been developed using thiophene-1,1-dioxides which are a versatile group of compounds that, to date, have been underutilised in organic synthesis. Substituted thiophene-1,1-dioxides can undergo Diels-Alder reactions with cyclopropenes to form cycloheptatrienes which can be converted to tropolone derivatives. |
| first_indexed | 2025-11-14T11:06:50Z |
| format | Thesis |
| id | curtin-20.500.11937-76286 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:06:50Z |
| publishDate | 2018 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-762862019-09-13T03:33:11Z New Routes to Troponoid Natural Products Wells, Jason Matthew Tropolones have antimalarial activity with a structure unique compared to current treatments. This study focuses on the development of new methods to prepare tropolones and devise a total synthesis of cordytropolone. A new synthesis of tropolones has been developed using thiophene-1,1-dioxides which are a versatile group of compounds that, to date, have been underutilised in organic synthesis. Substituted thiophene-1,1-dioxides can undergo Diels-Alder reactions with cyclopropenes to form cycloheptatrienes which can be converted to tropolone derivatives. 2018 Thesis http://hdl.handle.net/20.500.11937/76286 Curtin University fulltext |
| spellingShingle | Wells, Jason Matthew New Routes to Troponoid Natural Products |
| title | New Routes to Troponoid Natural Products |
| title_full | New Routes to Troponoid Natural Products |
| title_fullStr | New Routes to Troponoid Natural Products |
| title_full_unstemmed | New Routes to Troponoid Natural Products |
| title_short | New Routes to Troponoid Natural Products |
| title_sort | new routes to troponoid natural products |
| url | http://hdl.handle.net/20.500.11937/76286 |