Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs.
Staphylococcus aureus is a serious human and animal pathogen. Multilocus sequence type 612 (ST612) is the dominant methicillin-resistant S. aureus (MRSA) clone in certain South African hospitals and is sporadically isolated from horses and horse-associated veterinarians in Australia. Colonization an...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2019
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| Online Access: | http://purl.org/au-research/grants/arc/FT170100235 http://hdl.handle.net/20.500.11937/76269 |
| _version_ | 1848763658936516608 |
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| author | Murphy, Riley Ramsay, Josh Lee, Y. Pang, S. O'Dea, M. Pearson, J. Axon, J. Raby, E. Abdulgader, S. Whitelaw, A. Coombs, G. |
| author_facet | Murphy, Riley Ramsay, Josh Lee, Y. Pang, S. O'Dea, M. Pearson, J. Axon, J. Raby, E. Abdulgader, S. Whitelaw, A. Coombs, G. |
| author_sort | Murphy, Riley |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Staphylococcus aureus is a serious human and animal pathogen. Multilocus sequence type 612 (ST612) is the dominant methicillin-resistant S. aureus (MRSA) clone in certain South African hospitals and is sporadically isolated from horses and horse-associated veterinarians in Australia. Colonization and infection by ST612-MRSA is increasing in Western Australia. Whole-genome sequencing was performed for 51 ST612-MRSA isolated from Western Australian patients and healthcare workers, South African hospital patients, Australian veterinarians and New South Wales horses. Core-genome phylogenies suggested Australian equine and veterinarian-associated ST612 were monophyletic. Individual Western Australian isolates grouped either with this equine-associated lineage or more diverse lineages related to those in South African hospitals. Bioinformatic analyses of the complete ST612-MRSA reference genome SVH7513 confirmed ST612-MRSA was closely related to ST8 USA500 MRSA. Common use of rifampicin in South Africa and equine veterinarian practice may favor ST612-MRSA in these settings. ST612-MRSA-colonized humans and horses are potential reservoirs for MRSA in Australia. |
| first_indexed | 2025-11-14T11:06:58Z |
| format | Journal Article |
| id | curtin-20.500.11937-76269 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:06:58Z |
| publishDate | 2019 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-762692022-09-06T03:05:53Z Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs. Murphy, Riley Ramsay, Josh Lee, Y. Pang, S. O'Dea, M. Pearson, J. Axon, J. Raby, E. Abdulgader, S. Whitelaw, A. Coombs, G. MRSA Methicillin-resistant Staphylococcus aureus bacteremia equine molecular epidemiology zoonosis Staphylococcus aureus is a serious human and animal pathogen. Multilocus sequence type 612 (ST612) is the dominant methicillin-resistant S. aureus (MRSA) clone in certain South African hospitals and is sporadically isolated from horses and horse-associated veterinarians in Australia. Colonization and infection by ST612-MRSA is increasing in Western Australia. Whole-genome sequencing was performed for 51 ST612-MRSA isolated from Western Australian patients and healthcare workers, South African hospital patients, Australian veterinarians and New South Wales horses. Core-genome phylogenies suggested Australian equine and veterinarian-associated ST612 were monophyletic. Individual Western Australian isolates grouped either with this equine-associated lineage or more diverse lineages related to those in South African hospitals. Bioinformatic analyses of the complete ST612-MRSA reference genome SVH7513 confirmed ST612-MRSA was closely related to ST8 USA500 MRSA. Common use of rifampicin in South Africa and equine veterinarian practice may favor ST612-MRSA in these settings. ST612-MRSA-colonized humans and horses are potential reservoirs for MRSA in Australia. 2019 Journal Article http://hdl.handle.net/20.500.11937/76269 10.1016/j.ijantimicag.2019.08.022 eng http://purl.org/au-research/grants/arc/FT170100235 fulltext |
| spellingShingle | MRSA Methicillin-resistant Staphylococcus aureus bacteremia equine molecular epidemiology zoonosis Murphy, Riley Ramsay, Josh Lee, Y. Pang, S. O'Dea, M. Pearson, J. Axon, J. Raby, E. Abdulgader, S. Whitelaw, A. Coombs, G. Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs. |
| title | Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs. |
| title_full | Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs. |
| title_fullStr | Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs. |
| title_full_unstemmed | Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs. |
| title_short | Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs. |
| title_sort | multiple introductions of methicillin-resistant staphylococcus aureus st612 into western australia associated with both human and equine reservoirs. |
| topic | MRSA Methicillin-resistant Staphylococcus aureus bacteremia equine molecular epidemiology zoonosis |
| url | http://purl.org/au-research/grants/arc/FT170100235 http://hdl.handle.net/20.500.11937/76269 |