The Influence of Cholesterol on β-cell Function
Strong evidence that statin medication is linked to type II diabetes raises questions about the role of cholesterol in insulin secretion and pancreatic β-cell function. Experimentally induced changes in cellular cholesterol content attenuated insulin secretion robustly stimulated by both nutrient a...
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| Format: | Thesis |
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Curtin University
2019
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| Online Access: | http://hdl.handle.net/20.500.11937/76106 |
| _version_ | 1848763622753304576 |
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| author | Ellison, Gaewyn Colleen |
| author_facet | Ellison, Gaewyn Colleen |
| author_sort | Ellison, Gaewyn Colleen |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Strong evidence that statin medication is linked to type II diabetes raises questions about the role of cholesterol in insulin secretion and pancreatic β-cell function. Experimentally induced changes in cellular cholesterol content attenuated insulin secretion robustly stimulated by both nutrient and therapeutic secretagogues in β-cell models. The mechanisms of these adverse effects were investigated, including aspects of cellular metabolism, mitochondrial dysfunction, and effects on strategic proteins involved in glucose sensing, exocytosis and cholesterol transport. |
| first_indexed | 2025-11-14T11:06:24Z |
| format | Thesis |
| id | curtin-20.500.11937-76106 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:06:24Z |
| publishDate | 2019 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-761062021-07-26T01:09:21Z The Influence of Cholesterol on β-cell Function Ellison, Gaewyn Colleen Strong evidence that statin medication is linked to type II diabetes raises questions about the role of cholesterol in insulin secretion and pancreatic β-cell function. Experimentally induced changes in cellular cholesterol content attenuated insulin secretion robustly stimulated by both nutrient and therapeutic secretagogues in β-cell models. The mechanisms of these adverse effects were investigated, including aspects of cellular metabolism, mitochondrial dysfunction, and effects on strategic proteins involved in glucose sensing, exocytosis and cholesterol transport. 2019 Thesis http://hdl.handle.net/20.500.11937/76106 Curtin University fulltext |
| spellingShingle | Ellison, Gaewyn Colleen The Influence of Cholesterol on β-cell Function |
| title | The Influence of Cholesterol on β-cell Function |
| title_full | The Influence of Cholesterol on β-cell Function |
| title_fullStr | The Influence of Cholesterol on β-cell Function |
| title_full_unstemmed | The Influence of Cholesterol on β-cell Function |
| title_short | The Influence of Cholesterol on β-cell Function |
| title_sort | influence of cholesterol on β-cell function |
| url | http://hdl.handle.net/20.500.11937/76106 |