Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans
Intracranial hemorrhage can be a devastating complication associated with needle biopsies of the brain. Hemorrhage can occur to vessels located adjacent to the biopsy needle as tissue is aspirated into the needle and removed. No intraoperative technology exists to reliably identify blood vessels tha...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/76011 |
| _version_ | 1848763603244548096 |
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| author | Ramakonar, H. Quirk, B.C. Kirk, R.W. Li, J. Jacques, Angela Lind, C.R.P. McLaughlin, R.A. |
| author_facet | Ramakonar, H. Quirk, B.C. Kirk, R.W. Li, J. Jacques, Angela Lind, C.R.P. McLaughlin, R.A. |
| author_sort | Ramakonar, H. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Intracranial hemorrhage can be a devastating complication associated with needle biopsies of the brain. Hemorrhage can occur to vessels located adjacent to the biopsy needle as tissue is aspirated into the needle and removed. No intraoperative technology exists to reliably identify blood vessels that are at risk of damage. To address this problem, we developed an "imaging needle" that can visualize nearby blood vessels in real time. The imaging needle contains a miniaturized optical coherence tomography probe that allows differentiation of blood flow and tissue. In 11 patients, we were able to intraoperatively detect blood vessels (diameter, >500 mum) with a sensitivity of 91.2% and a specificity of 97.7%. This is the first reported use of an optical coherence tomography needle probe in human brain in vivo. These results suggest that imaging needles may serve as a valuable tool in a range of neurosurgical needle interventions. |
| first_indexed | 2025-11-14T11:06:05Z |
| format | Journal Article |
| id | curtin-20.500.11937-76011 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:06:05Z |
| publishDate | 2018 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-760112019-07-19T00:37:58Z Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans Ramakonar, H. Quirk, B.C. Kirk, R.W. Li, J. Jacques, Angela Lind, C.R.P. McLaughlin, R.A. Intracranial hemorrhage can be a devastating complication associated with needle biopsies of the brain. Hemorrhage can occur to vessels located adjacent to the biopsy needle as tissue is aspirated into the needle and removed. No intraoperative technology exists to reliably identify blood vessels that are at risk of damage. To address this problem, we developed an "imaging needle" that can visualize nearby blood vessels in real time. The imaging needle contains a miniaturized optical coherence tomography probe that allows differentiation of blood flow and tissue. In 11 patients, we were able to intraoperatively detect blood vessels (diameter, >500 mum) with a sensitivity of 91.2% and a specificity of 97.7%. This is the first reported use of an optical coherence tomography needle probe in human brain in vivo. These results suggest that imaging needles may serve as a valuable tool in a range of neurosurgical needle interventions. 2018 Journal Article http://hdl.handle.net/20.500.11937/76011 10.1126/sciadv.aav4992 eng http://creativecommons.org/licenses/by/4.0/ fulltext |
| spellingShingle | Ramakonar, H. Quirk, B.C. Kirk, R.W. Li, J. Jacques, Angela Lind, C.R.P. McLaughlin, R.A. Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans |
| title | Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans |
| title_full | Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans |
| title_fullStr | Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans |
| title_full_unstemmed | Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans |
| title_short | Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans |
| title_sort | intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans |
| url | http://hdl.handle.net/20.500.11937/76011 |