Antiprotozoals based on the inhibition of N-Myristoyltransferase
The research performed a protozoal structure activity investigation based on the transition state of N-Myristoyltransferase. This initial investigation synthesised a simplified transition state mimetic based from myristic acid and included alkene and phenoxy variation of the myristoyl chain. A serie...
| Main Author: | |
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| Format: | Thesis |
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Curtin University
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/74927 |
| _version_ | 1848763059339788288 |
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| author | Clegg, Robert Alexander Norman |
| author_facet | Clegg, Robert Alexander Norman |
| author_sort | Clegg, Robert Alexander Norman |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The research performed a protozoal structure activity investigation based on the transition state of N-Myristoyltransferase. This initial investigation synthesised a simplified transition state mimetic based from myristic acid and included alkene and phenoxy variation of the myristoyl chain. A series of Inhibitors were developed using a coenzyme-A fragment. Structures were targeted that were based on the statins (HMG-CoA inhibitors). Some of the compounds developed showed micro molar activities towards T. brucei and P. falciparum. |
| first_indexed | 2025-11-14T10:57:26Z |
| format | Thesis |
| id | curtin-20.500.11937-74927 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:57:26Z |
| publishDate | 2018 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-749272019-02-25T05:46:37Z Antiprotozoals based on the inhibition of N-Myristoyltransferase Clegg, Robert Alexander Norman The research performed a protozoal structure activity investigation based on the transition state of N-Myristoyltransferase. This initial investigation synthesised a simplified transition state mimetic based from myristic acid and included alkene and phenoxy variation of the myristoyl chain. A series of Inhibitors were developed using a coenzyme-A fragment. Structures were targeted that were based on the statins (HMG-CoA inhibitors). Some of the compounds developed showed micro molar activities towards T. brucei and P. falciparum. 2018 Thesis http://hdl.handle.net/20.500.11937/74927 Curtin University fulltext |
| spellingShingle | Clegg, Robert Alexander Norman Antiprotozoals based on the inhibition of N-Myristoyltransferase |
| title | Antiprotozoals based on the inhibition of N-Myristoyltransferase |
| title_full | Antiprotozoals based on the inhibition of N-Myristoyltransferase |
| title_fullStr | Antiprotozoals based on the inhibition of N-Myristoyltransferase |
| title_full_unstemmed | Antiprotozoals based on the inhibition of N-Myristoyltransferase |
| title_short | Antiprotozoals based on the inhibition of N-Myristoyltransferase |
| title_sort | antiprotozoals based on the inhibition of n-myristoyltransferase |
| url | http://hdl.handle.net/20.500.11937/74927 |