The role of dihydrosphingolipids in disease
Dihydrosphingolipids refer to sphingolipids early in the biosynthetic pathway that do not contain a C4-trans-double bond in the sphingoid backbone: 3-ketosphinganine (3-ketoSph), dihydrosphingosine (dhSph), dihydrosphingosine-1-phosphate (dhS1P) and dihydroceramide (dhCer). Recent advances in resear...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Birkhauser Verlag
2018
|
| Online Access: | http://hdl.handle.net/20.500.11937/74867 |
| _version_ | 1848763395808952320 |
|---|---|
| author | Magaye, R. Savira, F. Hua, Y. Kelly, D. Reid, Christopher Flynn, B. Liew, D. Wang, B. |
| author_facet | Magaye, R. Savira, F. Hua, Y. Kelly, D. Reid, Christopher Flynn, B. Liew, D. Wang, B. |
| author_sort | Magaye, R. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Dihydrosphingolipids refer to sphingolipids early in the biosynthetic pathway that do not contain a C4-trans-double bond in the sphingoid backbone: 3-ketosphinganine (3-ketoSph), dihydrosphingosine (dhSph), dihydrosphingosine-1-phosphate (dhS1P) and dihydroceramide (dhCer). Recent advances in research related to sphingolipid biochemistry have shed light on the importance of sphingolipids in terms of cellular signalling in health and disease. However, dihydrosphingolipids have received less attention and research is lacking especially in terms of their molecular mechanisms of action. This is despite studies implicating them in the pathophysiology of disease, for example dhCer in predicting type 2 diabetes in obese individuals, dhS1P in cardiovascular diseases and dhSph in hepato-renal toxicity. This review gives a comprehensive summary of research in the last 10–15 years on the dihydrosphingolipids, 3-ketoSph, dhSph, dhS1P and dhCer, and their relevant roles in different diseases. It also highlights gaps in research that could be of future interest. |
| first_indexed | 2025-11-14T11:02:47Z |
| format | Journal Article |
| id | curtin-20.500.11937-74867 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:02:47Z |
| publishDate | 2018 |
| publisher | Birkhauser Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-748672019-07-16T02:48:08Z The role of dihydrosphingolipids in disease Magaye, R. Savira, F. Hua, Y. Kelly, D. Reid, Christopher Flynn, B. Liew, D. Wang, B. Dihydrosphingolipids refer to sphingolipids early in the biosynthetic pathway that do not contain a C4-trans-double bond in the sphingoid backbone: 3-ketosphinganine (3-ketoSph), dihydrosphingosine (dhSph), dihydrosphingosine-1-phosphate (dhS1P) and dihydroceramide (dhCer). Recent advances in research related to sphingolipid biochemistry have shed light on the importance of sphingolipids in terms of cellular signalling in health and disease. However, dihydrosphingolipids have received less attention and research is lacking especially in terms of their molecular mechanisms of action. This is despite studies implicating them in the pathophysiology of disease, for example dhCer in predicting type 2 diabetes in obese individuals, dhS1P in cardiovascular diseases and dhSph in hepato-renal toxicity. This review gives a comprehensive summary of research in the last 10–15 years on the dihydrosphingolipids, 3-ketoSph, dhSph, dhS1P and dhCer, and their relevant roles in different diseases. It also highlights gaps in research that could be of future interest. 2018 Journal Article http://hdl.handle.net/20.500.11937/74867 10.1007/s00018-018-2984-8 Birkhauser Verlag restricted |
| spellingShingle | Magaye, R. Savira, F. Hua, Y. Kelly, D. Reid, Christopher Flynn, B. Liew, D. Wang, B. The role of dihydrosphingolipids in disease |
| title | The role of dihydrosphingolipids in disease |
| title_full | The role of dihydrosphingolipids in disease |
| title_fullStr | The role of dihydrosphingolipids in disease |
| title_full_unstemmed | The role of dihydrosphingolipids in disease |
| title_short | The role of dihydrosphingolipids in disease |
| title_sort | role of dihydrosphingolipids in disease |
| url | http://hdl.handle.net/20.500.11937/74867 |