Pericytes in Metastasis
Pericytes have long been known to contribute indirectly to tumour growth by regulating angiogenesis. Thus, remodelling tumour blood vessels to maintain blood supply is critical for continued tumour growth. A role for pericytes in restricting leakage of tumour cells through blood vessels has also bec...
| Main Authors: | , , |
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| Format: | Book Chapter |
| Published: |
Springer
2019
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| Online Access: | http://hdl.handle.net/20.500.11937/74819 |
| _version_ | 1848763381561950208 |
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| author | Pieterse, Z. Sinha, D. Kaur, Pritinder |
| author_facet | Pieterse, Z. Sinha, D. Kaur, Pritinder |
| author_sort | Pieterse, Z. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Pericytes have long been known to contribute indirectly to tumour growth by regulating angiogenesis. Thus, remodelling tumour blood vessels to maintain blood supply is critical for continued tumour growth. A role for pericytes in restricting leakage of tumour cells through blood vessels has also become evident given that adequate pericyte coverage of these blood vessels is critical for maintaining vascular permeability. Interestingly, the relocation of pericytes from blood vessels to the tumour microenvironment results in the emergence of different properties in these cells that actively promote tumour growth and metastasis-functions not associated with their well-studied role in vascular stability and permeability. These form the focus of this review. |
| first_indexed | 2025-11-14T11:02:34Z |
| format | Book Chapter |
| id | curtin-20.500.11937-74819 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:02:34Z |
| publishDate | 2019 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-748192019-08-07T00:52:13Z Pericytes in Metastasis Pieterse, Z. Sinha, D. Kaur, Pritinder Pericytes have long been known to contribute indirectly to tumour growth by regulating angiogenesis. Thus, remodelling tumour blood vessels to maintain blood supply is critical for continued tumour growth. A role for pericytes in restricting leakage of tumour cells through blood vessels has also become evident given that adequate pericyte coverage of these blood vessels is critical for maintaining vascular permeability. Interestingly, the relocation of pericytes from blood vessels to the tumour microenvironment results in the emergence of different properties in these cells that actively promote tumour growth and metastasis-functions not associated with their well-studied role in vascular stability and permeability. These form the focus of this review. 2019 Book Chapter http://hdl.handle.net/20.500.11937/74819 10.1007/978-3-030-16908-4_5 Springer restricted |
| spellingShingle | Pieterse, Z. Sinha, D. Kaur, Pritinder Pericytes in Metastasis |
| title | Pericytes in Metastasis |
| title_full | Pericytes in Metastasis |
| title_fullStr | Pericytes in Metastasis |
| title_full_unstemmed | Pericytes in Metastasis |
| title_short | Pericytes in Metastasis |
| title_sort | pericytes in metastasis |
| url | http://hdl.handle.net/20.500.11937/74819 |