Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies.
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. A better understanding of how the pathological mechanisms drive the deterioration of...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/74676 |
| _version_ | 1848763341666779136 |
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| author | Guo, Q. Wang, Y. Xu, Daniel Nossent, J. Pavlos, N. Xu, J. |
| author_facet | Guo, Q. Wang, Y. Xu, Daniel Nossent, J. Pavlos, N. Xu, J. |
| author_sort | Guo, Q. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. A better understanding of how the pathological mechanisms drive the deterioration of RA progress in individuals is urgently required in order to develop therapies that will effectively treat patients at each stage of the disease progress. Here we dissect the etiology and pathology at specific stages: (i) triggering, (ii) maturation, (iii) targeting, and (iv) fulminant stage, concomitant with hyperplastic synovium, cartilage damage, bone erosion, and systemic consequences. Modern pharmacologic therapies (including conventional, biological, and novel potential small molecule disease-modifying anti-rheumatic drugs) remain the mainstay of RA treatment and there has been significant progress toward achieving disease remission without joint deformity. Despite this, a significant proportion of RA patients do not effectively respond to the current therapies and thus new drugs are urgently required. This review discusses recent advances of our understanding of RA pathogenesis, disease modifying drugs, and provides perspectives on next generation therapeutics for RA. |
| first_indexed | 2025-11-14T11:01:55Z |
| format | Journal Article |
| id | curtin-20.500.11937-74676 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:01:55Z |
| publishDate | 2018 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-746762019-07-18T01:08:56Z Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. Guo, Q. Wang, Y. Xu, Daniel Nossent, J. Pavlos, N. Xu, J. Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. A better understanding of how the pathological mechanisms drive the deterioration of RA progress in individuals is urgently required in order to develop therapies that will effectively treat patients at each stage of the disease progress. Here we dissect the etiology and pathology at specific stages: (i) triggering, (ii) maturation, (iii) targeting, and (iv) fulminant stage, concomitant with hyperplastic synovium, cartilage damage, bone erosion, and systemic consequences. Modern pharmacologic therapies (including conventional, biological, and novel potential small molecule disease-modifying anti-rheumatic drugs) remain the mainstay of RA treatment and there has been significant progress toward achieving disease remission without joint deformity. Despite this, a significant proportion of RA patients do not effectively respond to the current therapies and thus new drugs are urgently required. This review discusses recent advances of our understanding of RA pathogenesis, disease modifying drugs, and provides perspectives on next generation therapeutics for RA. 2018 Journal Article http://hdl.handle.net/20.500.11937/74676 10.1038/s41413-018-0016-9 http://creativecommons.org/licenses/by/4.0/ fulltext |
| spellingShingle | Guo, Q. Wang, Y. Xu, Daniel Nossent, J. Pavlos, N. Xu, J. Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. |
| title | Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. |
| title_full | Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. |
| title_fullStr | Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. |
| title_full_unstemmed | Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. |
| title_short | Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. |
| title_sort | rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. |
| url | http://hdl.handle.net/20.500.11937/74676 |