Developing evidence-based recommendations for optimal interpregnancy intervals in high-income countries: Protocol for an international cohort study
Introduction Short interpregnancy interval (IPI) has been linked to adverse pregnancy outcomes. WHO recommends waiting at least 2 years after a live birth and 6 months after miscarriage or induced termination before conception of another pregnancy. The evidence underpinning these recommendations lar...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
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BM J Group
2019
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1099655 http://hdl.handle.net/20.500.11937/74651 |
| _version_ | 1848763334888783872 |
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| author | Marinovich, M. Regan, Annette Gissler, M. Magnus, M. Håberg, S. Padula, A. Mayo, J. Shaw, G. Ball, Stephen Malacova, Eva Gebremedhin, Amanuel Tesfay Nassar, N. Marston, C. De Klerk, N. Betran, A. Pereira, Gavin |
| author_facet | Marinovich, M. Regan, Annette Gissler, M. Magnus, M. Håberg, S. Padula, A. Mayo, J. Shaw, G. Ball, Stephen Malacova, Eva Gebremedhin, Amanuel Tesfay Nassar, N. Marston, C. De Klerk, N. Betran, A. Pereira, Gavin |
| author_sort | Marinovich, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Introduction Short interpregnancy interval (IPI) has been linked to adverse pregnancy outcomes. WHO recommends waiting at least 2 years after a live birth and 6 months after miscarriage or induced termination before conception of another pregnancy. The evidence underpinning these recommendations largely relies on data from low/middle-income countries. Furthermore, recent epidemiological investigations have suggested that these studies may overestimate the effects of IPI due to residual confounding. Future investigations of IPI effects in high-income countries drawing from large, population-based data sources are needed to inform IPI recommendations. We aim to assess the impact of IPIs on maternal and child health outcomes in high-income countries. Methods and analysis This international longitudinal retrospective cohort study will include more than 18 million pregnancies, making it the largest study to investigate IPI in high-income countries. Population-based data from Australia, Finland, Norway and USA will be used. Birth records in each country will be used to identify consecutive pregnancies. Exact dates of birth and clinical best estimates of gestational length will be used to estimate IPI. Administrative birth and health data sources with >99% coverage in each country will be used to identify maternal sociodemographics, pregnancy complications, details of labour and delivery, birth and child health information. We will use matched and unmatched regression models to investigate the impact of IPI on maternal and infant outcomes, and conduct meta-analysis to pool results across countries. Ethics and dissemination Ethics boards at participating sites approved this research (approval was not required in Finland). Findings will be published in peer-reviewed journals and presented at international conferences, and will inform recommendations for optimal IPI in high-income countries. Findings will provide important information for women and families planning future pregnancies and for clinicians providing prenatal care and giving guidance on family planning. |
| first_indexed | 2025-11-14T11:01:49Z |
| format | Journal Article |
| id | curtin-20.500.11937-74651 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:01:49Z |
| publishDate | 2019 |
| publisher | BM J Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-746512023-04-05T06:25:26Z Developing evidence-based recommendations for optimal interpregnancy intervals in high-income countries: Protocol for an international cohort study Marinovich, M. Regan, Annette Gissler, M. Magnus, M. Håberg, S. Padula, A. Mayo, J. Shaw, G. Ball, Stephen Malacova, Eva Gebremedhin, Amanuel Tesfay Nassar, N. Marston, C. De Klerk, N. Betran, A. Pereira, Gavin Introduction Short interpregnancy interval (IPI) has been linked to adverse pregnancy outcomes. WHO recommends waiting at least 2 years after a live birth and 6 months after miscarriage or induced termination before conception of another pregnancy. The evidence underpinning these recommendations largely relies on data from low/middle-income countries. Furthermore, recent epidemiological investigations have suggested that these studies may overestimate the effects of IPI due to residual confounding. Future investigations of IPI effects in high-income countries drawing from large, population-based data sources are needed to inform IPI recommendations. We aim to assess the impact of IPIs on maternal and child health outcomes in high-income countries. Methods and analysis This international longitudinal retrospective cohort study will include more than 18 million pregnancies, making it the largest study to investigate IPI in high-income countries. Population-based data from Australia, Finland, Norway and USA will be used. Birth records in each country will be used to identify consecutive pregnancies. Exact dates of birth and clinical best estimates of gestational length will be used to estimate IPI. Administrative birth and health data sources with >99% coverage in each country will be used to identify maternal sociodemographics, pregnancy complications, details of labour and delivery, birth and child health information. We will use matched and unmatched regression models to investigate the impact of IPI on maternal and infant outcomes, and conduct meta-analysis to pool results across countries. Ethics and dissemination Ethics boards at participating sites approved this research (approval was not required in Finland). Findings will be published in peer-reviewed journals and presented at international conferences, and will inform recommendations for optimal IPI in high-income countries. Findings will provide important information for women and families planning future pregnancies and for clinicians providing prenatal care and giving guidance on family planning. 2019 Journal Article http://hdl.handle.net/20.500.11937/74651 10.1136/bmjopen-2018-027941 http://purl.org/au-research/grants/nhmrc/1099655 http://purl.org/au-research/grants/nhmrc/1117105 http://purl.org/au-research/grants/nhmrc/1138425 http://purl.org/au-research/grants/nhmrc/1141510 http://purl.org/au-research/grants/nhmrc/1067066 http://creativecommons.org/licenses/by/4.0/ BM J Group fulltext |
| spellingShingle | Marinovich, M. Regan, Annette Gissler, M. Magnus, M. Håberg, S. Padula, A. Mayo, J. Shaw, G. Ball, Stephen Malacova, Eva Gebremedhin, Amanuel Tesfay Nassar, N. Marston, C. De Klerk, N. Betran, A. Pereira, Gavin Developing evidence-based recommendations for optimal interpregnancy intervals in high-income countries: Protocol for an international cohort study |
| title | Developing evidence-based recommendations for optimal interpregnancy intervals in high-income countries: Protocol for an international cohort study |
| title_full | Developing evidence-based recommendations for optimal interpregnancy intervals in high-income countries: Protocol for an international cohort study |
| title_fullStr | Developing evidence-based recommendations for optimal interpregnancy intervals in high-income countries: Protocol for an international cohort study |
| title_full_unstemmed | Developing evidence-based recommendations for optimal interpregnancy intervals in high-income countries: Protocol for an international cohort study |
| title_short | Developing evidence-based recommendations for optimal interpregnancy intervals in high-income countries: Protocol for an international cohort study |
| title_sort | developing evidence-based recommendations for optimal interpregnancy intervals in high-income countries: protocol for an international cohort study |
| url | http://purl.org/au-research/grants/nhmrc/1099655 http://purl.org/au-research/grants/nhmrc/1099655 http://purl.org/au-research/grants/nhmrc/1099655 http://purl.org/au-research/grants/nhmrc/1099655 http://purl.org/au-research/grants/nhmrc/1099655 http://hdl.handle.net/20.500.11937/74651 |