Alternative methods to animal studies for the evaluation of topical/transdermal drug delivery systems
It is critical to develop an effective understanding of the interaction between the drug, delivery system and skin in order to predict and assess skin penetration and permeation. Experimental models for the assessment of topical and transdermal delivery systems must permit evaluation of these comple...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/74503 |
| _version_ | 1848763293302259712 |
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| author | Junqueira Garcia, M. de Vasconcellos, F. Raffier, C. Roberts, M. Grice, J. Benson, Heather Leite-Silva, V. |
| author_facet | Junqueira Garcia, M. de Vasconcellos, F. Raffier, C. Roberts, M. Grice, J. Benson, Heather Leite-Silva, V. |
| author_sort | Junqueira Garcia, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | It is critical to develop an effective understanding of the interaction between the drug, delivery system and skin in order to predict and assess skin penetration and permeation. Experimental models for the assessment of topical and transdermal delivery systems must permit evaluation of these complex interactions. Whilst in the past, animal models were commonly used, recent regulatory guidelines, based on 3R principles (refinement, reduction, replacement), encourage the rational use of animals. Alternative methods have been proposed for use in the development of topical and transdermal delivery systems which are often used in combination. We will review the current state of the art in alternative methods for topical and transdermal delivery systems development, including technologies that can assist in the characterization of skin penetration/permeation studies. |
| first_indexed | 2025-11-14T11:01:09Z |
| format | Journal Article |
| id | curtin-20.500.11937-74503 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:01:09Z |
| publishDate | 2018 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-745032019-07-15T06:13:48Z Alternative methods to animal studies for the evaluation of topical/transdermal drug delivery systems Junqueira Garcia, M. de Vasconcellos, F. Raffier, C. Roberts, M. Grice, J. Benson, Heather Leite-Silva, V. It is critical to develop an effective understanding of the interaction between the drug, delivery system and skin in order to predict and assess skin penetration and permeation. Experimental models for the assessment of topical and transdermal delivery systems must permit evaluation of these complex interactions. Whilst in the past, animal models were commonly used, recent regulatory guidelines, based on 3R principles (refinement, reduction, replacement), encourage the rational use of animals. Alternative methods have been proposed for use in the development of topical and transdermal delivery systems which are often used in combination. We will review the current state of the art in alternative methods for topical and transdermal delivery systems development, including technologies that can assist in the characterization of skin penetration/permeation studies. 2018 Journal Article http://hdl.handle.net/20.500.11937/74503 10.2174/1568026618666180412153214 restricted |
| spellingShingle | Junqueira Garcia, M. de Vasconcellos, F. Raffier, C. Roberts, M. Grice, J. Benson, Heather Leite-Silva, V. Alternative methods to animal studies for the evaluation of topical/transdermal drug delivery systems |
| title | Alternative methods to animal studies for the evaluation of topical/transdermal drug delivery systems |
| title_full | Alternative methods to animal studies for the evaluation of topical/transdermal drug delivery systems |
| title_fullStr | Alternative methods to animal studies for the evaluation of topical/transdermal drug delivery systems |
| title_full_unstemmed | Alternative methods to animal studies for the evaluation of topical/transdermal drug delivery systems |
| title_short | Alternative methods to animal studies for the evaluation of topical/transdermal drug delivery systems |
| title_sort | alternative methods to animal studies for the evaluation of topical/transdermal drug delivery systems |
| url | http://hdl.handle.net/20.500.11937/74503 |