Young adult sequelae of adolescent cannabis use:an integrative analysis
Background: Debate continues about the consequences of adolescent cannabis use. Existing data are limited in statistical power to examine rarer outcomes and less common, heavier patterns of cannabis use than those already investigated; furthermore, evidence has a piecemeal approach to reporting of y...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Elsevier Ltd
2014
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/7449 |
| _version_ | 1848745371491106816 |
|---|---|
| author | Silins, E. Horwood, J. Patton, G. Fergusson, D. Olsson, C. Hutchinson, D. Spry, E. Toumbourou, J. Degenhardt, L. Swift, W. Coffey, C. Tait, Robert Letcher, P. Copeland, J. Mattick, R. Allsop, Steve Hall, W. Hayatbakhsh, R. Little, K. Najman, J. Skinner, R. Slade, T. |
| author_facet | Silins, E. Horwood, J. Patton, G. Fergusson, D. Olsson, C. Hutchinson, D. Spry, E. Toumbourou, J. Degenhardt, L. Swift, W. Coffey, C. Tait, Robert Letcher, P. Copeland, J. Mattick, R. Allsop, Steve Hall, W. Hayatbakhsh, R. Little, K. Najman, J. Skinner, R. Slade, T. |
| author_sort | Silins, E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Debate continues about the consequences of adolescent cannabis use. Existing data are limited in statistical power to examine rarer outcomes and less common, heavier patterns of cannabis use than those already investigated; furthermore, evidence has a piecemeal approach to reporting of young adult sequelae. We aimed to provide a broad picture of the psychosocial sequelae of adolescent cannabis use. Methods: We integrated participant-level data from three large, long-running longitudinal studies from Australia and New Zealand: the Australian Temperament Project, the Christchurch Health and Development Study, and the Victorian Adolescent Health Cohort Study. We investigated the association between the maximum frequency of cannabis use before age 17 years (never, less than monthly, monthly or more, weekly or more, or daily) and seven developmental outcomes assessed up to age 30 years (high-school completion, attainment of university degree, cannabis dependence, use of other illicit drugs, suicide attempt, depression, and welfare dependence). The number of participants varied by outcome (N=2537 to N=3765).Findings: We recorded clear and consistent associations and dose-response relations between the frequency of adolescent cannabis use and all adverse young adult outcomes. After covariate adjustment, compared with individuals who had never used cannabis, those who were daily users before age 17 years had clear reductions in the odds of high-school completion (adjusted odds ratio 0•37, 95% CI 0•20—0•66) and degree attainment (0•38, 0•22—0•66), and substantially increased odds of later cannabis dependence (17•95, 9•44—34•12), use of other illicit drugs (7•80, 4•46—13•63), and suicide attempt (6•83, 2•04—22•90). Interpretation: Adverse sequelae of adolescent cannabis use are wide ranging and extend into young adulthood. Prevention or delay of cannabis use in adolescence is likely to have broad health and social benefits. Efforts to reform cannabis legislation should be carefully assessed to ensure they reduce adolescent cannabis use and prevent potentially adverse developmental effects. |
| first_indexed | 2025-11-14T06:16:18Z |
| format | Journal Article |
| id | curtin-20.500.11937-7449 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:16:18Z |
| publishDate | 2014 |
| publisher | Elsevier Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-74492019-02-19T05:35:29Z Young adult sequelae of adolescent cannabis use:an integrative analysis Silins, E. Horwood, J. Patton, G. Fergusson, D. Olsson, C. Hutchinson, D. Spry, E. Toumbourou, J. Degenhardt, L. Swift, W. Coffey, C. Tait, Robert Letcher, P. Copeland, J. Mattick, R. Allsop, Steve Hall, W. Hayatbakhsh, R. Little, K. Najman, J. Skinner, R. Slade, T. adolescent Cannabis longitudinal Background: Debate continues about the consequences of adolescent cannabis use. Existing data are limited in statistical power to examine rarer outcomes and less common, heavier patterns of cannabis use than those already investigated; furthermore, evidence has a piecemeal approach to reporting of young adult sequelae. We aimed to provide a broad picture of the psychosocial sequelae of adolescent cannabis use. Methods: We integrated participant-level data from three large, long-running longitudinal studies from Australia and New Zealand: the Australian Temperament Project, the Christchurch Health and Development Study, and the Victorian Adolescent Health Cohort Study. We investigated the association between the maximum frequency of cannabis use before age 17 years (never, less than monthly, monthly or more, weekly or more, or daily) and seven developmental outcomes assessed up to age 30 years (high-school completion, attainment of university degree, cannabis dependence, use of other illicit drugs, suicide attempt, depression, and welfare dependence). The number of participants varied by outcome (N=2537 to N=3765).Findings: We recorded clear and consistent associations and dose-response relations between the frequency of adolescent cannabis use and all adverse young adult outcomes. After covariate adjustment, compared with individuals who had never used cannabis, those who were daily users before age 17 years had clear reductions in the odds of high-school completion (adjusted odds ratio 0•37, 95% CI 0•20—0•66) and degree attainment (0•38, 0•22—0•66), and substantially increased odds of later cannabis dependence (17•95, 9•44—34•12), use of other illicit drugs (7•80, 4•46—13•63), and suicide attempt (6•83, 2•04—22•90). Interpretation: Adverse sequelae of adolescent cannabis use are wide ranging and extend into young adulthood. Prevention or delay of cannabis use in adolescence is likely to have broad health and social benefits. Efforts to reform cannabis legislation should be carefully assessed to ensure they reduce adolescent cannabis use and prevent potentially adverse developmental effects. 2014 Journal Article http://hdl.handle.net/20.500.11937/7449 10.1016/S2215-0366(14)70307-4 Elsevier Ltd fulltext |
| spellingShingle | adolescent Cannabis longitudinal Silins, E. Horwood, J. Patton, G. Fergusson, D. Olsson, C. Hutchinson, D. Spry, E. Toumbourou, J. Degenhardt, L. Swift, W. Coffey, C. Tait, Robert Letcher, P. Copeland, J. Mattick, R. Allsop, Steve Hall, W. Hayatbakhsh, R. Little, K. Najman, J. Skinner, R. Slade, T. Young adult sequelae of adolescent cannabis use:an integrative analysis |
| title | Young adult sequelae of adolescent cannabis use:an integrative analysis |
| title_full | Young adult sequelae of adolescent cannabis use:an integrative analysis |
| title_fullStr | Young adult sequelae of adolescent cannabis use:an integrative analysis |
| title_full_unstemmed | Young adult sequelae of adolescent cannabis use:an integrative analysis |
| title_short | Young adult sequelae of adolescent cannabis use:an integrative analysis |
| title_sort | young adult sequelae of adolescent cannabis use:an integrative analysis |
| topic | adolescent Cannabis longitudinal |
| url | http://hdl.handle.net/20.500.11937/7449 |