Multimetal organic frameworks as drug carriers: Aceclofenac as a drug candidate
Background: Multimetal organic frameworks (M-MOFs) were synthesized by including a second metal ion with the main base metal in the synthesis process to enhance their applications for drug delivery. Aceclofenac (ACF), a nonsteroidal anti-inflammatory analgesic drug of low aqueous solubility, was sel...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
Dove Medical Press Ltd.
2019
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| Online Access: | http://hdl.handle.net/20.500.11937/74417 |
| _version_ | 1848763269294063616 |
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| author | Al Haydar, Muder Abid, H. Sunderland, B. Wang, Shaobin |
| author_facet | Al Haydar, Muder Abid, H. Sunderland, B. Wang, Shaobin |
| author_sort | Al Haydar, Muder |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Multimetal organic frameworks (M-MOFs) were synthesized by including a second metal ion with the main base metal in the synthesis process to enhance their applications for drug delivery. Aceclofenac (ACF), a nonsteroidal anti-inflammatory analgesic drug of low aqueous solubility, was selected as a candidate for the drug delivery system Purpose: This study aimed to evaluate the loading capacity (LC) and entrapment efficiency (EE) percentages of multi-Material of Institute Lavoisier (MIL)-100(Fe) (M-MIL-100(Fe)) for ACF. Materials and methods: Hydrothermal synthesis procedure was used to prepare multi-MIL-100(Fe) samples (Zn I-MIL-100(Fe), Zn II-MIL-100(Fe), Ca I-MIL-100(Fe), Ca II-MIL-100-(Fe), Mg I-MIL-100(Fe), Mg II-MIL-100(Fe), Mn I-MIL-100(Fe), and Mn II-MIL-100(Fe)). The characterization of M-MIL-100(Fe) samples was evaluated by X-ray powder diffraction (XRD), Fourier transform infrared spectra, scanning electron microscope (SEM), TGA, and N2 adsorption isotherms. The LC of M-MIL-100(Fe) and EE of ACF were determined. Nuclear magnetic resonance (NMR) and zeta-potential analyses were employed to confirm qualitatively the drug loading within M-MIL-100(Fe). Results: The ACF LC of MIL-100(Fe) was 27%, whereas the LC of M-MIL-100(Fe) was significantly increased and ranged from 37% in Ca I-MIL-100(Fe) to about 57% and 59% in Mn II-MIL-100(Fe) and Zn II-MIL-100(Fe), respectively. The ACF@M-MOFs release profiles showed slow release rates in phosphate buffer solutions at pH 6.8 and 7.4 as compared to the ACF@MIL-100(Fe). Conclusion: Therefore, M-MOFs showed a significant potential as a carrier for drug delivery systems. |
| first_indexed | 2025-11-14T11:00:46Z |
| format | Journal Article |
| id | curtin-20.500.11937-74417 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:00:46Z |
| publishDate | 2019 |
| publisher | Dove Medical Press Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-744172019-03-14T01:09:44Z Multimetal organic frameworks as drug carriers: Aceclofenac as a drug candidate Al Haydar, Muder Abid, H. Sunderland, B. Wang, Shaobin Background: Multimetal organic frameworks (M-MOFs) were synthesized by including a second metal ion with the main base metal in the synthesis process to enhance their applications for drug delivery. Aceclofenac (ACF), a nonsteroidal anti-inflammatory analgesic drug of low aqueous solubility, was selected as a candidate for the drug delivery system Purpose: This study aimed to evaluate the loading capacity (LC) and entrapment efficiency (EE) percentages of multi-Material of Institute Lavoisier (MIL)-100(Fe) (M-MIL-100(Fe)) for ACF. Materials and methods: Hydrothermal synthesis procedure was used to prepare multi-MIL-100(Fe) samples (Zn I-MIL-100(Fe), Zn II-MIL-100(Fe), Ca I-MIL-100(Fe), Ca II-MIL-100-(Fe), Mg I-MIL-100(Fe), Mg II-MIL-100(Fe), Mn I-MIL-100(Fe), and Mn II-MIL-100(Fe)). The characterization of M-MIL-100(Fe) samples was evaluated by X-ray powder diffraction (XRD), Fourier transform infrared spectra, scanning electron microscope (SEM), TGA, and N2 adsorption isotherms. The LC of M-MIL-100(Fe) and EE of ACF were determined. Nuclear magnetic resonance (NMR) and zeta-potential analyses were employed to confirm qualitatively the drug loading within M-MIL-100(Fe). Results: The ACF LC of MIL-100(Fe) was 27%, whereas the LC of M-MIL-100(Fe) was significantly increased and ranged from 37% in Ca I-MIL-100(Fe) to about 57% and 59% in Mn II-MIL-100(Fe) and Zn II-MIL-100(Fe), respectively. The ACF@M-MOFs release profiles showed slow release rates in phosphate buffer solutions at pH 6.8 and 7.4 as compared to the ACF@MIL-100(Fe). Conclusion: Therefore, M-MOFs showed a significant potential as a carrier for drug delivery systems. 2019 Journal Article http://hdl.handle.net/20.500.11937/74417 10.2147/DDDT.S182983 https://creativecommons.org/licenses/by-nc/3.0/ Dove Medical Press Ltd. fulltext |
| spellingShingle | Al Haydar, Muder Abid, H. Sunderland, B. Wang, Shaobin Multimetal organic frameworks as drug carriers: Aceclofenac as a drug candidate |
| title | Multimetal organic frameworks as drug carriers: Aceclofenac as a drug candidate |
| title_full | Multimetal organic frameworks as drug carriers: Aceclofenac as a drug candidate |
| title_fullStr | Multimetal organic frameworks as drug carriers: Aceclofenac as a drug candidate |
| title_full_unstemmed | Multimetal organic frameworks as drug carriers: Aceclofenac as a drug candidate |
| title_short | Multimetal organic frameworks as drug carriers: Aceclofenac as a drug candidate |
| title_sort | multimetal organic frameworks as drug carriers: aceclofenac as a drug candidate |
| url | http://hdl.handle.net/20.500.11937/74417 |